“…Physicians ' non-compliance with dosage guidelines is seen as a major reason for therapy failure in antidepressive pharmacotherapy [11,24,30,32] . As an explanation, some authors have suggested that the prescribing physicians lack professional knowledge [5,13,14,42] . In order to test this assumption, we randomly assigned physicians to either a group which was exposed to dosage guidelines with detailed information on how to prescribe correctly, or to a control group, which was left uninformed.…”