“…Moreover, in the cat the only change made by iproniazid in the reserpine syndrome is the prevention of extreme miosis; no excitement, panting, tremor or pupillary dilation is produced. This is so in spite of the fact that the 5-HT content of cat brain after reserpine and iproniazid is high [1261]. Keeping in mind these essential data it is extremely improbable that the central excitatory effects elicited by reserpine in iproniazid pretreated animals may be ascribed, as postulated by BRODIE et at.…”