Psychotic symptoms are associated with lower cortical folding in youth at risk for mental illness

Drobinin, Vladislav; Gestel, Holly Van; Zwicker, Alyson; MacKenzie, Lynn E.; Cumby, Jill; Patterson, Victoria C.; Vallis, Emily Howes; Campbell, Niamh; Hájek, Tomáš; Helmick, Carl; Schmidt, Matthias; Alda, Martin; Bowen, Chris V.; Uher, Rudolf

doi:10.1503/jpn.180144

Cited by 9 publications

(6 citation statements)

References 68 publications

(65 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1, the searches yielded 2223 references, of which 666 were excluded as duplicates, 1243 were excluded following review of title and abstract, and a further 259 were excluded following full text review. The remaining 55 studies met inclusion criteria (Addington et al, 2019; Albertella & Norberg, 2012; Auther et al, 2012; Barkhuizen, Taylor, Freeman, & Ronald, 2019; Bassett, Schunk, & Crouch, 1996; Bechtold, Hipwell, Lewis, Loeber, & Pardini, 2016; Besli, Ikiz, Yildirim, & Saltik, 2015; Bourque, Afzali, O'Leary-Barrett, & Conrod, 2017a; Bourque et al, 2017b; Brink et al, 2020; Colins, Vermeiren, Noom, & Broekaert, 2013; Colins et al, 2009; Cruz & Domínguez, 2011; DaBreo-Otero, 2021; Dolphin, Dooley, & Fitzgerald, 2015; Drobinin et al, 2020; Evans & Raistrick, 1987; Fonseca-Pedrero, Lucas-Molina, Pérez-Albéniz, Inchausti, & Ortuño-Sierra, 2020; Forrester, 2012; Friedman, Utada, Glickman, & Morrissey, 1987; Garland & Howard, 2010; Goulter, McMahon, & Dodge, 2019; Harley et al, 2010; Hartsell, 2021; Hides et al, 2009; Jones, Calkins, Scott, Bach, & Gur, 2017; Jones, Gage, & Heron, 2018; Konings, Henquet, Maharajh, Hutchinson, & Van Os, 2008; Lansing, Plante, Fennema-Notestine, Golshan, & Beck, 2018; Levy & Weitzman, 2019; Lindgren et al, 2010; Mackie, Castellanos-Ryan, & Conrod, 2011; Mackie et al, 2021; McGorry et al, 1995; McMahon et al, 2021; Miettunen et al, 2008; Mundy, Robertson, Robertson, & Greenblatt, 1990; Opaleye et al, 2009; Rimvall et al, 2020; Schifano, Forza, & Gallimberti, 1994; Scott et al, 2009; Shakoor et al, 2015; Shervette, Schydlower, Lampe, & Fearnow, 1979; Shrier, Harris, Kurland, & Knight, 2003; Stain et al, 2016; Stainton et al, 2021; Sunderland et al, 2021; Tekulve, Alexander, & Tormoehlen, 2014; van Gastel et al, 2012; Vaughn, 2006; Wang et al, 2022; Watts et al, 2021; Whitt, Garland, & Howard, 2012; Yilmaz Kafali et al, 2022; ...…”

Section: Resultsmentioning

confidence: 99%

“…1 , the searches yielded 2223 references, of which 666 were excluded as duplicates, 1243 were excluded following review of title and abstract, and a further 259 were excluded following full text review. The remaining 55 studies met inclusion criteria (Addington et al, 2019 ; Albertella & Norberg, 2012 ; Auther et al, 2012 ; Barkhuizen, Taylor, Freeman, & Ronald, 2019 ; Bassett, Schunk, & Crouch, 1996 ; Bechtold, Hipwell, Lewis, Loeber, & Pardini, 2016 ; Besli, Ikiz, Yildirim, & Saltik, 2015 ; Bourque, Afzali, O'Leary-Barrett, & Conrod, 2017a ; Bourque et al, 2017b ; Brink et al, 2020 ; Colins, Vermeiren, Noom, & Broekaert, 2013 ; Colins et al, 2009 ; Cruz & Domínguez, 2011 ; DaBreo-Otero, 2021 ; Dolphin, Dooley, & Fitzgerald, 2015 ; Drobinin et al, 2020 ; Evans & Raistrick, 1987 ; Fonseca-Pedrero, Lucas-Molina, Pérez-Albéniz, Inchausti, & Ortuño-Sierra, 2020 ; Forrester, 2012 ; Friedman, Utada, Glickman, & Morrissey, 1987 ; Garland & Howard, 2010 ; Goulter, McMahon, & Dodge, 2019 ; Harley et al, 2010 ; Hartsell, 2021 ; Hides et al, 2009 ; Jones, Calkins, Scott, Bach, & Gur, 2017 ; Jones, Gage, & Heron, 2018 ; Konings, Henquet, Maharajh, Hutchinson, & Van Os, 2008 ; Lansing, Plante, Fennema-Notestine, Golshan, & Beck, 2018 ; Levy & Weitzman, 2019 ; Lindgren et al, 2010 ; Mackie, Castellanos-Ryan, & Conrod, 2011 ; Mackie et al, 2021 ; McGorry et al, 1995 ; McMahon et al, 2021 ; Miettunen et al, 2008 ; Mundy, Robertson, Robertson, & Greenblatt, 1990 ; Opaleye et al, 2009 ; Rimvall et al, 2020 ; Schifano, Forza, & Gallimberti, 1994 ; Scott et al, 2009 ; Shakoor et al, 2015 ; Shervette, Schydlower, Lampe, & Fearnow, 1979 ; Shrier, Harris, Kurland, & Knight, …”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Substance use and psychotic-like experiences in young people: a systematic review and meta-analysis

Matheson

Laurie²,

Laurens³

2022

Psychol. Med.

View full text Add to dashboard Cite

This study aimed to systematically review and synthesise the available evidence on the prevalence and associations between psychotic-like experiences (PLEs) and substance use in children and adolescents aged ⩽17 years, prior to the typical age of development of prodromal symptoms of psychosis. As substance use has been associated with earlier age of psychosis onset and more severe illness, identifying risk processes in the premorbid phase of the illness may offer opportunities to prevent the development of prodromal symptoms and psychotic illness. MEDLINE, PsycINFO, and CINAHL databases were searched for chart review, case-control, cohort, twin, and cross-sectional studies. Study reporting was assessed using the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist, and pooled evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Searches identified 55 studies that met inclusion criteria. Around two-in-five substance users reported PLEs [rate = 0.41, 95% confidence interval (CI) 0.32–0.51; low quality evidence], and one-in-five with PLEs reported using substances (rate = 0.19, 95% CI 0.12–0.28; moderate-to-high quality evidence). Substance users were nearly twice as likely to report PLEs than non-users [odds ratio (OR) 1.77, 95% CI 1.55–2.02; moderate quality evidence], and those with PLEs were twice as likely to use substances than those not reporting PLEs (OR 1.93, 95% CI 1.55–2.41; very low quality evidence). Younger age was associated with greater odds of PLEs in substance users compared to non-users. Young substance users may represent a subclinical at-risk group for psychosis. Developing early detection and intervention for both substance use and PLEs may reduce long-term adverse outcomes.

show abstract

Section: Resultsmentioning

confidence: 99%

“…1 , the searches yielded 2223 references, of which 666 were excluded as duplicates, 1243 were excluded following review of title and abstract, and a further 259 were excluded following full text review. The remaining 55 studies met inclusion criteria (Addington et al, 2019 ; Albertella & Norberg, 2012 ; Auther et al, 2012 ; Barkhuizen, Taylor, Freeman, & Ronald, 2019 ; Bassett, Schunk, & Crouch, 1996 ; Bechtold, Hipwell, Lewis, Loeber, & Pardini, 2016 ; Besli, Ikiz, Yildirim, & Saltik, 2015 ; Bourque, Afzali, O'Leary-Barrett, & Conrod, 2017a ; Bourque et al, 2017b ; Brink et al, 2020 ; Colins, Vermeiren, Noom, & Broekaert, 2013 ; Colins et al, 2009 ; Cruz & Domínguez, 2011 ; DaBreo-Otero, 2021 ; Dolphin, Dooley, & Fitzgerald, 2015 ; Drobinin et al, 2020 ; Evans & Raistrick, 1987 ; Fonseca-Pedrero, Lucas-Molina, Pérez-Albéniz, Inchausti, & Ortuño-Sierra, 2020 ; Forrester, 2012 ; Friedman, Utada, Glickman, & Morrissey, 1987 ; Garland & Howard, 2010 ; Goulter, McMahon, & Dodge, 2019 ; Harley et al, 2010 ; Hartsell, 2021 ; Hides et al, 2009 ; Jones, Calkins, Scott, Bach, & Gur, 2017 ; Jones, Gage, & Heron, 2018 ; Konings, Henquet, Maharajh, Hutchinson, & Van Os, 2008 ; Lansing, Plante, Fennema-Notestine, Golshan, & Beck, 2018 ; Levy & Weitzman, 2019 ; Lindgren et al, 2010 ; Mackie, Castellanos-Ryan, & Conrod, 2011 ; Mackie et al, 2021 ; McGorry et al, 1995 ; McMahon et al, 2021 ; Miettunen et al, 2008 ; Mundy, Robertson, Robertson, & Greenblatt, 1990 ; Opaleye et al, 2009 ; Rimvall et al, 2020 ; Schifano, Forza, & Gallimberti, 1994 ; Scott et al, 2009 ; Shakoor et al, 2015 ; Shervette, Schydlower, Lampe, & Fearnow, 1979 ; Shrier, Harris, Kurland, & Knight, …”

Section: Resultsmentioning

confidence: 99%

Substance use and psychotic-like experiences in young people: a systematic review and meta-analysis

Matheson

Laurie²,

Laurens³

2022

Psychol. Med.

View full text Add to dashboard Cite

show abstract

“…However, alternative models explaining cortical gyrification are emerging ( 47 ). Interestingly, in a similar cohort of high-risk youth between 9 and 25 years old, in those having a parent with a severe psychiatric disorder, a diminished gyrification index across all brain areas was associated with psychotic symptoms ( 48 ). In another study in young adults, trait anxiety was associated with decreased gyrification in the left parietal gyrus, a result that we report as well ( 49 ).…”

Section: Discussionmentioning

confidence: 99%

Irritability Is Associated With Decreased Cortical Surface Area and Anxiety With Decreased Gyrification During Brain Development

Piguet

Mihailov²,

Grigis³

et al. 2021

Front. Psychiatry

View full text Add to dashboard Cite

Background: Brain development is of utmost importance for the emergence of psychiatric disorders, as the most severe of them arise before 25 years old. However, little is known regarding how early transdiagnostic symptoms, in a dimensional framework, are associated with cortical development. Anxiety and irritability are central vulnerability traits for subsequent mood and anxiety disorders. In this study, we investigate how these dimensions are related to structural changes in the brain to understand how they may increase the transition risk to full-blown disorders.Methods: We used the opportunity of an open access developmental cohort, the Healthy Brain Network, to investigate associations between cortical surface markers and irritability and anxiety scores as measured by parents and self-reports.Results: We found that in 658 young people (with a mean age of 11.6) the parental report of irritability is associated with decreased surface area in the bilateral rostral prefrontal cortex and the precuneus. Furthermore, parental reports of anxiety were associated with decreased local gyrification index in the anterior cingulate cortex and dorsomedial prefrontal cortex.Conclusions: These results are consistent with current models of emotion regulation network maturation, showing decreased surface area or gyrification index in regions associated with impaired affective control in mood and anxiety disorders. Our results highlight how dimensional traits may increase vulnerability for these disorders.

show abstract

“…Abnormalities in cortical surface areas and cortical thickness have been consistently observed in schizophrenia as well, including in FEP ( 9 , 10 ). Drobinin et al ( 11 ) reported that in youth at risk for mental illness displayed an overall trend toward lower cortical folding across all brain regions. Results from previous studies of cortical folding in schizophrenia showed abnormal folding in large regions of the cerebral cortex across several independent samples of patients with schizophrenia, mostly affecting frontotemporal regions ( 12 – 14 ) and increased structural variability of regional measures of brain morphology ( 15 , 16 ).…”

Section: Introductionmentioning

confidence: 99%

Chaos analysis of the brain topology in first-episode psychosis and clinical high risk patients

Κορδά

Andreou²,

Avram³

et al. 2022

Front. Psychiatry

View full text Add to dashboard Cite

Structural MRI studies in first-episode psychosis (FEP) and in clinical high risk (CHR) patients have consistently shown volumetric abnormalities in frontal, temporal, and cingulate cortex areas. The aim of the present study was to employ chaos analysis for the identification of brain topology differences in people with psychosis. Structural MRI were acquired from 77 FEP, 73 CHR and 44 healthy controls (HC). Chaos analysis of the gray matter distribution was performed: First, the distances of each voxel from the center of mass in the gray matter image was calculated. Next, the distances multiplied by the voxel intensity were represented as a spatial-series, which then was analyzed by extracting the Largest-Lyapunov-Exponent (lambda). The lambda brain map depicts thus how the gray matter topology changes. Between-group differences were identified by (a) comparing the lambda brain maps, which resulted in statistically significant differences in FEP and CHR compared to HC; and (b) matching the lambda series with the Morlet wavelet, which resulted in statistically significant differences in the scalograms of FEP against CHR and HC. The proposed framework using spatial-series extraction enhances the between-group differences of FEP, CHR and HC subjects, verifies diagnosis-relevant features and may potentially contribute to the identification of structural biomarkers for psychosis.

show abstract

Psychotic symptoms are associated with lower cortical folding in youth at risk for mental illness

Cited by 9 publications

References 68 publications

Substance use and psychotic-like experiences in young people: a systematic review and meta-analysis

Substance use and psychotic-like experiences in young people: a systematic review and meta-analysis

Irritability Is Associated With Decreased Cortical Surface Area and Anxiety With Decreased Gyrification During Brain Development

Chaos analysis of the brain topology in first-episode psychosis and clinical high risk patients

Contact Info

Product

Resources

About