Psychotic disorders, dopaminergic agents and EEG/MEG resting-state functional connectivity: A systematic review

Mackintosh, Amatya; Bock, Renate de; Lim, Zehwi; Trulley, Valerie-Noelle; Schmidt, André; Borgwardt, Stefan; Andreou, Christina

doi:10.1016/j.neubiorev.2020.10.021

Cited by 21 publications

(24 citation statements)

References 97 publications

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“…Global patterns of functional connectivity during N2 sleep were also affected in SCZ. While there is substantial evidence of abnormal waking connectivity as a hallmark of SCZ from fMRI ( Dong et al, 2018 ; van den Heuvel and Fornito, 2014 ) and M/EEG studies ( Mackintosh et al, 2021 ; Maran et al, 2016 ), connectivity findings in sleep are more scarce and restricted to coherence in spindle ( Wamsley et al, 2012 ; Sun et al, 2021 ; Markovic et al, 2020 ) and slow/delta frequency bands ( Bartsch et al, 2019 ), mostly pointing to reduced connectivity in patients, although there is also evidence of increased coherence ( Markovic et al, 2020 ). To the best of our knowledge, only two prior studies have evaluated coherence at other frequencies during sleep.…”

Section: Discussionmentioning

confidence: 99%

Non-rapid eye movement sleep and wake neurophysiology in schizophrenia

Kozhemiako

Wang

Chen-guang

et al. 2022

eLife

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Motivated by the potential of objective neurophysiological markers to index thalamocortical function in patients with severe psychiatric illnesses, we comprehensively characterized key non-rapid eye movement (NREM) sleep parameters across multiple domains, their interdependencies, and their relationship to waking event-related potentials and symptom severity. In 72 schizophrenia (SCZ) patients and 58 controls, we confirmed a marked reduction in sleep spindle density in SCZ and extended these findings to show that fast and slow spindle properties were largely uncorrelated. We also describe a novel measure of slow oscillation and spindle interaction that was attenuated in SCZ. The main sleep findings were replicated in a demographically distinct sample, and a joint model, based on multiple NREM components, statistically predicted disease status in the replication cohort. Although also altered in patients, auditory event-related potentials elicited during wake were unrelated to NREM metrics. Consistent with a growing literature implicating thalamocortical dysfunction in SCZ, our characterization identifies independent NREM and wake EEG biomarkers that may index distinct aspects of SCZ pathophysiology and point to multiple neural mechanisms underlying disease heterogeneity. This study lays the groundwork for evaluating these neurophysiological markers, individually or in combination, to guide efforts at treatment and prevention as well as identifying individuals most likely to benefit from specific interventions.

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Section: Discussionmentioning

confidence: 99%

Non-rapid eye movement sleep and wake neurophysiology in schizophrenia

Kozhemiako

Wang

Chen-guang

et al. 2022

eLife

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“…A possible explanation would be an influence of dopaminergic drugs on the networks in the schizophrenia studies or an emerging dysconnectivity throughout the disease. The number of resting-state studies exploring drug-naïve resting-state oscillatory patterns before and after therapy is still limited ( 72 ). Future studies with drug-naïve patients and studies within the ketamine model of schizophrenia could involve modulation by dopaminergic substances.…”

Section: Discussionmentioning

confidence: 99%

Ketamine Alters Functional Gamma and Theta Resting-State Connectivity in Healthy Humans: Implications for Schizophrenia Treatment Targeting the Glutamate System

et al. 2021

Self Cite

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Disturbed functional connectivity is assumed to cause neurocognitive deficits in patients suffering from schizophrenia. A Glutamate N-methyl-D-aspartate receptor (NMDAR) dysfunction has been suggested as a possible mechanism underlying altered connectivity in schizophrenia, especially in the gamma- and theta-frequency range. The present study aimed to investigate the effects of the NMDAR-antagonist ketamine on resting-state power, functional connectivity, and schizophrenia-like psychopathological changes in healthy volunteers. In a placebo-controlled crossover design, 25 healthy subjects were recorded using resting-state 64-channel-electroencephalography (EEG) (eyes closed). The imaginary coherence-based Multivariate Interaction Measure (MIM) was used to measure gamma and theta connectivity across 80 cortical regions. The network-based statistic was applied to identify involved networks under ketamine. Psychopathology was assessed with the Positive and Negative Syndrome Scale (PANSS) and the 5-Dimensional Altered States of Consciousness Rating Scale (5D-ASC). Ketamine caused an increase in all PANSS (p < 0.001) as well as 5D-ASC scores (p < 0.01). Significant increases in resting-state gamma and theta power were observed under ketamine compared to placebo (p < 0.05). The source-space analysis revealed two distinct networks with an increased mean functional gamma- or theta-band connectivity during the ketamine session. The gamma-network consisted of midline regions, the cuneus, the precuneus, and the bilateral posterior cingulate cortices, while the theta-band network involved the Heschl gyrus, midline regions, the insula, and the middle cingulate cortex. The current source density (CSD) within the gamma-band correlated negatively with the PANSS negative symptom score, and the activity within the gamma-band network correlated negatively with the subjective changed meaning of percepts subscale of the 5D-ASC. These results are in line with resting-state patterns seen in people who have schizophrenia and argue for a crucial role of the glutamate system in mediating dysfunctional gamma- and theta-band-connectivity in schizophrenia. Resting-state networks could serve as biomarkers for the response to glutamatergic drugs or drug development efforts within the glutamate system.

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“…Global patterns of functional connectivity during N2 sleep were also affected in SCZ. While there is substantial evidence of abnormal waking connectivity as a hallmark of SCZ from fMRI 51,52 and M/EEG studies 53,54 , connectivity findings in sleep are more scarce and restricted to coherence in spindle 20,24,34 and slow/delta frequency bands 49 , mostly pointing to reduced connectivity in patients, although there is also evidence of increased coherence 34 . To the best of our knowledge, only two prior studies have evaluated coherence at other frequencies during sleep.…”

Section: Discussionmentioning

confidence: 99%

Non-rapid eye movement sleep and wake neurophysiology in schizophrenia

Kozhemiako

Wang

Chen-guang

et al. 2021

Preprint

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Motivated by the potential of objective neurophysiological markers to index thalamocortical function in patients with severe psychiatric illnesses, we comprehensively characterized key NREM sleep parameters across multiple domains, their interdependencies, and their relationship to waking event-related potentials and symptom severity. In 130 schizophrenia (SCZ) patients and controls, we confirmed a marked reduction in sleep spindle density in SCZ and extended these findings to show that only slow spindles predicted symptom severity, and that fast and slow spindle properties were largely uncorrelated. We also describe a novel measure of slow oscillation and spindle interaction that was attenuated in SCZ. The main sleep findings were replicated in a demographically distinct sample, and a joint model, based on multiple NREM components, predicted disease status in the replication cohort. Although also altered in patients, auditory event-related potentials elicited during wake were unrelated to NREM metrics. Consistent with a growing literature implicating thalamocortical dysfunction in SCZ, our characterization identifies independent NREM and wake EEG biomarkers that may index distinct aspects of SCZ pathophysiology and point to multiple neural mechanisms underlying disease heterogeneity. This study lays the groundwork for evaluating these neurophysiological markers, individually or in combination, to guide efforts at treatment and prevention as well as identifying individuals most likely to benefit from specific interventions.

show abstract

Psychotic disorders, dopaminergic agents and EEG/MEG resting-state functional connectivity: A systematic review

Cited by 21 publications

References 97 publications

Non-rapid eye movement sleep and wake neurophysiology in schizophrenia

Non-rapid eye movement sleep and wake neurophysiology in schizophrenia

Ketamine Alters Functional Gamma and Theta Resting-State Connectivity in Healthy Humans: Implications for Schizophrenia Treatment Targeting the Glutamate System

Non-rapid eye movement sleep and wake neurophysiology in schizophrenia

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