Psychotic disorders amid the COVID-19 pandemic: a consideration of risks and impacts

Abstract

Purpose of reviewThe COVID-19 pandemic has had a severe and widespread global impact but particularly for those with psychosis. This review summarizes recent evidence on the relationship between the COVID-19 pandemic and psychotic disorders, highlighting the risks faced by these individuals including the negative impacts on treatment services, complications from contracting COVID-19, and the acceptability of digital interventions.Recent findingsMortality, morbidity, and infection outcomes are among the worst for individuals with psychotic disorders. Presentation rates for psychotic disorders are elevated at emergency departments compared with before the COVID-19 pandemic; demand for inpatient services has increased, and there have been complications in access because of pandemic restrictions. COVID-19 related stressors have led to the exacerbation and incidence of psychotic symptoms among individuals with and without preexisting psychotic diagnoses. Digital interventions may be an acceptable method for maintaining patient contact and treatment during extended isolation.SummaryMore data is needed on the longitudinal trajectory for psychotic symptoms post-COVID-19 infection and pandemic restrictions to better support individuals with psychotic disorders. Development of a long-term pandemic management plan is needed to monitor and support psychiatric health across the population.

Second-generation antipsychotics and metabolic syndrome: a role for mitochondria

“…Schizophrenia and psychosis have a lifetime prevalence of 1% and a high global economic burden (1,2). The aetiology of psychosis is multifactorial, including genetics, substance misuse, and medical conditions, like infections, and autoimmune disorders (3)(4)(5)(6). Psychosis is primarily treated with antipsychotic medications (APs) but a variety of comorbidities associated with psychosis means antidepressants or antianxiety medications are prescribed alongside (1).…”