Psychotherapeutic interventions in individuals at risk of developing bipolar disorder: a systematic review

Pfennig, Andrea; Correll, Christoph U.; Marx, Carolin; Rottmann-Wolf, Maren; Meyer, Thomas D.; Bauer, Michael; Leopold, Karolina

doi:10.1111/eip.12082

Cited by 30 publications

(23 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…31 Our map identified more than four times as many studies of the early stages of bipolar disorder as the previous systematic reviews in the specialty (29 studies as compared with zero to seven studies identified in the systematic reviews) 27–30 . However, comparison with existing evidence maps of psychosis and depression indicates that work in bipolar disorder is lagging behind these areas of investigation.…”

Section: Discussionmentioning

confidence: 78%

“…However, these studies do not address the potential benefits of therapy to high-risk or subsyndromal cases of bipolar disorder (stages 0–1), or to first-episode cases in young people (stage 2). Four systematic reviews 27–30 of psychological interventions for mixed populations of children, adolescents, young adults, and those people at high risk or having already had a first episode of bipolar disorder, have identified 0–5 completed and two ongoing studies at the time of writing. These findings might suggest that only few investigations are undertaken in this area.…”

Section: Bipolar Disorder: Clinical Staging and Psychological Therapiesmentioning

confidence: 99%

See 1 more Smart Citation

An evidence map of psychosocial interventions for the earliest stages of bipolar disorder

Vallarino

Henry

Étain

et al. 2015

The Lancet Psychiatry

View full text Add to dashboard Cite

Depression, schizophrenia, and bipolar disorder are three of the four most burdensome problems in people aged under 25 years. In psychosis and depression, psychological interventions are effective, low-risk, and high-benefit approaches for patients at high risk of first-episode or early-onset disorders. We review the use of psychological interventions for early-stage bipolar disorder in patients aged 15–25 years. Because previous systematic reviews had struggled to identify information about this emerging sphere of research, we used evidence mapping to help us identify the extent, distribution, and methodological quality of evidence because the gold standard approaches were only slightly informative or appropriate. This strategy identified 29 studies in three target groups: ten studies in populations at high risk for bipolar disorder, five studies in patients with a first episode, and 14 studies in patients with early-onset bipolar disorder. Of the 20 completed studies, eight studies were randomised trials, but only two had sample sizes of more than 100 individuals. The main interventions used were family, cognitive behavioural, and interpersonal therapies. Only behavioural family therapies were tested across all of our three target groups. Although the available interventions were well adapted to the level of maturity and social environment of young people, few interventions target specific developmental psychological or physiological processes (eg, ruminative response style or delayed sleep phase), or offer detailed strategies for the management of substance use or physical health.

show abstract

Section: Discussionmentioning

confidence: 78%

Section: Bipolar Disorder: Clinical Staging and Psychological Therapiesmentioning

confidence: 99%

An evidence map of psychosocial interventions for the earliest stages of bipolar disorder

Vallarino

Henry

Étain

et al. 2015

The Lancet Psychiatry

View full text Add to dashboard Cite

show abstract

“…When considering the possibility of emergent BD in an adolescent, it is not sufficient to screen for symptoms of BD, given the limitations of the DSM (Kowatch et al, 2004) and non-specificity of common symptoms such as irritability and impulsivity (Pfennig et al, 2014). Furthermore, various factors can trigger mania without a diagnosis of BD being appropriate, such as substance use, sleep deprivation and thyroid conditions (Kowatch et al, 2004).…”

Section: Signs Of Future Bd In Adolescentsmentioning

confidence: 99%

Early intervention for bipolar disorder in adolescents: A psychosocial perspective

McAulay

Mond

Touyz

2017

Early Intervention Psych

View full text Add to dashboard Cite

show abstract

“…The prevalence is as low as 1.8% (Van Meter et al 2011) in the pediatric population; however, when broader diagnostic criteria are used, the rates rise up to 6.7% in the United States (Van Meter et al 2011). BD is associated with significant morbidity and oftentimes the pharmacotherapy may be inadequate in resolving symptoms (Deckersbach et al 2014;Pfennig et al 2014). More than 50% of patients diagnosed with BD have onset of their illness prior to 20 years of age (Lish et al 1994;Morselli et al 2003;Kessler et al 2005a;Blumberg 2008), and subsyndromal symptoms may be experienced years earlier (Chang 2007).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D₃Supplemental Treatment for Mania in Youth with Bipolar Spectrum Disorders

Sikoglu

Navarro

Starr

et al. 2015

Journal of Child and Adolescent Psychopharmacology

View full text Add to dashboard Cite

Objective: We aimed to determine the effect of an open-label 8 week Vitamin D 3 supplementation on manic symptoms, anterior cingulate cortex (ACC) glutamate, and c-aminobutyric acid (GABA) in youth exhibiting symptoms of mania; that is, patients with bipolar spectrum disorders (BSD). We hypothesized that an 8 week Vitamin D 3 supplementation would improve symptoms of mania, decrease ACC glutamate, and increase ACC GABA in BSD patients. Single time point metabolite levels were also evaluated in typically developing children (TD). Methods: The BSD group included patients not only diagnosed with BD but also those exhibiting bipolar symptomology, including BD not otherwise specified (BD-NOS) and subthreshold mood ratings (Young Mania Rating Scale [YMRS] ‡ 8 and Clinical Global Impressions -Severity [CGI-S] ‡ 3). Inclusion criteria were: male or female participants, 6-17 years old. Sixteen youth with BSD exhibiting manic symptoms and 19 TD were included. BSD patients were asked to a take daily dose (2000 IU) of Vitamin D 3 (for 8 weeks) as a supplement. Neuroimaging data were acquired in both groups at baseline, and also for the BSD group at the end of 8 week Vitamin D 3 supplementation. Results: Baseline ACC GABA/creatine (Cr) was lower in BSD than in TD (F[1,31] = 8.91, p = 0.007). Following an 8 week Vitamin D 3 supplementation, in BSD patients, there was a significant decrease in YMRS scores (t = -3.66, p = 0.002, df = 15) and Children's Depression Rating Scale (CDRS) scores (t = -2.93, p = 0.01, df = 15); and a significant increase in ACC GABA (t = 3.18, p = 0.007, df = 14). Conclusions: Following an 8 week open label trial with Vitamin D 3 , BSD patients exhibited improvement in their mood symptoms in conjunction with their brain neurochemistry.

show abstract

Psychotherapeutic interventions in individuals at risk of developing bipolar disorder: a systematic review

Cited by 30 publications

References 59 publications

An evidence map of psychosocial interventions for the earliest stages of bipolar disorder

An evidence map of psychosocial interventions for the earliest stages of bipolar disorder

Early intervention for bipolar disorder in adolescents: A psychosocial perspective

Vitamin D₃Supplemental Treatment for Mania in Youth with Bipolar Spectrum Disorders

Contact Info

Product

Resources

About

Psychotherapeutic interventions in individuals at risk of developing bipolar disorder: a systematic review

Cited by 30 publications

References 59 publications

An evidence map of psychosocial interventions for the earliest stages of bipolar disorder

An evidence map of psychosocial interventions for the earliest stages of bipolar disorder

Early intervention for bipolar disorder in adolescents: A psychosocial perspective

Vitamin D3Supplemental Treatment for Mania in Youth with Bipolar Spectrum Disorders

Contact Info

Product

Resources

About

Vitamin D₃Supplemental Treatment for Mania in Youth with Bipolar Spectrum Disorders