Medically unexplained physical symptoms (MUPS) are a frequent phenomenon. Understanding adults and adolescents' lived experience with MUPS is essential for providing adequate care, yet a rigorous synthesis of existing studies is missing. Objective: This study aimed to summarize findings from primary qualitative studies focused on adults' and adolescents' experience of living with MUPS. Design: Qualitative studies were searched in the PsycINFO, PsycARTICLES, and Medline databases and manually. A total of 23 resources met the inclusion criteria and were subjected to a qualitative meta-summary. Results: Eight themes were found across the set of primary studies, namely, the need to feel understood, struggling with isolation, 'sense of self' in strain, facing uncertainty, searching for explanations, ambivalence about diagnosis, disappointed by healthcare, and active coping. Conclusion: The eight themes represent the core struggles adults' and adolescents' with MUPS face in their lives, psychologically and socially. Although these themes appear to be universal, the analysis also revealed considerable variability of experience in terms of expectations from healthcare professionals, attitude towards formal diagnoses, ability to cope with the illness, or potential to transform the illness experience into personal growth. Addressing this diversity of needs represents a significant challenge for the healthcare system.Medically unexplained physical symptoms (MUPS) represent a highly frequent group of complaints in healthcare. The 12-month prevalence of MUPS in primary care was estimated to be as high as 49% (Haller et al., 2015), although the accuracy of this estimate remains doubtful. Not only are MUPS connected with specific challenges for practitioners, but they are also associated with specific experiences for patients, which may influence the course of the treatment. Therefore, understanding the lived experience of adults and adolescents with MUPS is an essential aspect of adequate medical care.The term MUPS has been extensively debated. While some authors distinguish particular syndromes, such as chronic fatigue syndrome (CFS), fibromyalgia (FM), psychogenic nonepileptic seizures (PNES), and irritable bowel syndrome (IBS) (Wessely