Psychosocial Stress Related to the Loss of a Close Relative the Year Before or During Pregnancy and Risk of Preeclampsia

László, Krisztina D.; Liu, Xiaoqin; Svensson, Tobias; Wikström, Anna‐Karin; Li, Jiong; Olsen, Jørn; Obel, Carsten; Vestergaard, Mogens; Cnattingius, Sven

doi:10.1161/hypertensionaha.111.00550

Cited by 36 publications

(46 citation statements)

References 38 publications

(51 reference statements)

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“…Previous works reported that stress could induce PE in pregnant rats and women (László et al, 2013;Takiuti et al, 2002). We demonstrate for the first time that GC exposure in early placentation could lead to PE-related manifestations in pregnant rats, supporting that GC exposure in early placentation is a potential stimulus for PE development.…”

Section: Discussionsupporting

confidence: 82%

“…Accumulating evidence suggest the adverse effects of GC exposure and stress on pregnancy (László et al, 2013;Lin et al, 2013;Michael and Papageorghiou, 2008;Xu et al, 2013). Previous works reported that stress could induce PE in pregnant rats and women (László et al, 2013;Takiuti et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, a previous work reported that stress in early pregnancy could induce the rat PE (Takiuti et al, 2002). Furthermore, László et al showed that stress exposure in the first trimester of pregnancy may lead to an increased risk of early-onset PE via influencing early placentation (László et al, 2013), while Hogg et al demonstrated that early onset PE is associated with altered GC-signaling (Hogg et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…Maternal stress or GCs abnormality may result in adverse pregnancy outcomes (Klebanoff et al, 1990;László et al, 2013;Michael and Papageorghiou, 2008;Woods et al, 2010). We demonstrated recently that stress-mediated increase in GC levels is directly http://dx.doi.org/10.1016/j.ygcen.2015.09.019 0016-6480/Ó 2015 Elsevier Inc. All rights reserved.…”

Section: Introductionmentioning

confidence: 99%

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Glucocorticoid exposure in early placentation induces preeclampsia in rats via interfering trophoblast development

Zhang

Liu

Zeng

et al. 2016

General and Comparative Endocrinology

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Glucocorticoid exposure in early placentation induces preeclampsia in rats via interfering trophoblast development

Zhang

Liu

Zeng

et al. 2016

General and Comparative Endocrinology

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“…It can be argued that many of these models are not accurate reflections of the type of stress women are likely to experience during pregnancy, which often have a social basis, for example, bullying, pressure at work/heavy workload, bereavement, intimate partner abuse or social instability/disadvantage (Bjorkqvist 2001, Valladares et al 2009, Lee et al 2011, Katz 2012, Laszlo et al 2013, Mahenge et al 2013; thus, animal models of prenatal stress that involve a social component may provide better insight for translational approaches.…”

Section: Introductionmentioning

confidence: 99%

Effects of maternal exposure to social stress during pregnancy: consequences for mother and offspring

2013

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A suboptimal in utero environment, for example, as a result of maternal stress, can have detrimental effects on the pregnancy and long-term adverse 'programming' effects on the offspring. This article focuses on the effects of prenatal social stress on the mother, her pregnancy and the offspring, since these issues have ethological relevance in both animals and humans. The consequences of social stress exposure depend on when during pregnancy the stress occurs, and many of the effects on the offspring are sex specific. Social stress during early pregnancy tends to result in pregnancy loss, whereas stress exposure later in pregnancy, when the mother has already invested considerable resources in the foetuses, results in programmed offspring of low birth weight: a risk factor for various adulthood diseases. Neuroendocrine and behavioural responses to stress in the offspring are particularly sensitive to foetal programming by prenatal stress, indicated by enhanced hypothalamo-pituitary-adrenal (HPA) axis responses and increased anxiety behaviour, which result from permanent changes in the offspring's brain. The dysregulation of HPA axis function may also interfere with other systems, for example, the hypothalamic-pituitary-gonadal axis, as there is evidence for alterations in steroidogenesis, reproductive potential and impaired reproductive/social behaviours in prenatally stressed offspring. Prenatal social stress also programmes future maternal behaviour, highlighting the potential for negative phenotypes to be transmitted to future generations. The possible mechanisms through which maternal stress during pregnancy is transmitted to the foetuses and the foetal brain is programmed by prenatal stress and the potential to overwrite programming of the offspring are discussed.Reproduction (2013) 146 R175-R189

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Maternal hypertensive disorders and neurodevelopmental disorders in offspring: a population-based cohort in two Nordic countries

et al. 2021

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Maternal hypertensive disorders during pregnancy (HDP) have been associated with neuropsychiatric problems in offspring. We aim to investigate the associations between specific types of maternal HDP and offspring neurodevelopmental disorders and further examine whether the timing of onset and severity of HDP would affect these associations. The study population consisted of 4,489,044 live-born singletons in Denmark during 1978–2012 and Sweden during 1987–2010. Maternal HDP was categorized into chronic hypertension, gestational hypertension, and pre-eclampsia; pre-eclampsia was further stratified according to timing (early-onset, late-onset), or severity (moderate, severe) of the disease. Neurodevelopmental disorders, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and intellectual disability (ID), were defined by ICD-coded register diagnosis. Cox regression was used to calculate hazard ratios (HR) while adjusting for potential confounders, and sibling analyses assessed the influence of unmeasured shared familial factors. Maternal HDP was associated with increased risks of ADHD (HR, 1.24; 95% confidence interval [CI], 1.20–1.28), ASD (1.29 [1.24–1.34]), and ID (1.58 [1.50–1.66]) in offspring, respectively, which was mostly driven by pre-eclampsia. The strongest associations were observed for early-onset and severe pre-eclampsia, and the corresponding HRs for ADHD, ASD and ID were 1.93 [1.73–2.16], 1.86 [1.61–2.15], and 3.99 [3.42–4.65], respectively. The results were similar in the sibling analyses. The associations between maternal HDP and offspring neurodevelopmental disorders were consistent across the subgroups of sex, preterm status, parity, maternal age and psychiatric disorders. Maternal HDP, especially early-onset pre-eclampsia, are associated with increased risks of ADHD, ASD, and ID in particular, independent of shared familial factors.

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Psychosocial Stress Related to the Loss of a Close Relative the Year Before or During Pregnancy and Risk of Preeclampsia

Cited by 36 publications

References 38 publications

Glucocorticoid exposure in early placentation induces preeclampsia in rats via interfering trophoblast development

Glucocorticoid exposure in early placentation induces preeclampsia in rats via interfering trophoblast development

Effects of maternal exposure to social stress during pregnancy: consequences for mother and offspring

Maternal hypertensive disorders and neurodevelopmental disorders in offspring: a population-based cohort in two Nordic countries

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