Psychosocial stress is associated with benign breast disease in young Chinese women: results from Project ELEFANT

Barrow, Timothy M.; Peng, Cheng; Wilson, Ander; Wang, Hao; Liu, Hongbin; Shen, Lilin; Tang, Naijun; Sae-Lee, Chanachai; Li, Penghui; Guo, Liqiong; Byun, Hyang‐Min

doi:10.1007/s10549-018-4979-4

Cited by 11 publications

(6 citation statements)

References 47 publications

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“…Project ELEFANT is a newly developed population study based in Tianjin, China that comprises three population studies: Baby ELEFANT (age 0, n = 48,762); Young ELEFANT (mean age 30, n = 366,474); and Elderly ELEFANT (mean age 65, n = 6,503) [18]. Complete blood counts, blood pressure, fasting blood glucose level, serum alanine amino transferase enzyme level, high sensitivity C-reactive protein (hs-CRP) serum level, thyroid stimulating hormone (THS) level, body mass index (BMI) and other clinical characteristics were measured during routine check-ups.…”

Section: Methodsmentioning

confidence: 99%

Occupational noise exposure is associated with hypertension in China: Results from project ELEFANT

et al. 2018

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ObjectivesWe investigated the association between occupational noise exposure and the risk of elevated blood pressure and hypertension by stage in young adults.MethodsWe utilized 124,286 young adults (18–40 years) from the Project ELEFANT study. We categorized occupational noise exposure as high (75 dBA noise exposure for more than 4 hours per day) or low, and measured blood pressure (mmHg) and categorized participants by hypertension stage (normal, elevated, Stage 1, Stage 2). We applied adjusted logistic regression models to identify associations with hypertension risk, and we further examined the noise-BMI, noise-gender, and noise-residence interactions on hypertension risk in separate models.ResultsHigh occupational noise exposure was associated with increases in blood pressure among participants with elevated blood pressure (Estimate = 0.23, 95% CI: 1.09, 1.46, p = 0.0009), in Stage 1 hypertension (Estimate = 0.15, 95% CI: 1.06, 1.25, p = 0.0008), and in Stage 2 hypertension (Estimate = 0.41 95% CI: 1.31, 1.73, p<0.0001). Likewise, noise exposure-BMI interaction was consistently positively associated with increases in blood pressure in participants with elevated blood pressure (Estimate = 0.71, 95% CI: 1.55, 2.69, p<0.0001), in Stage 1 hypertension (Estimate = 0.78, 95% CI: 1.82, 2.61, p<0.0001), and in Stage 2 hypertension (Estimate = 2.06, 95% CI: 5.64, 10.81, p<0.0001). The noise exposure-male interaction showed higher risk for hypertension compared to the noise exposure-female interaction in participants with elevated blood pressure (Estimate = 1.24, 95% CI: 2.56, 4.71, p<0.0001), Stage 1 (Estimate = 1.67, 95% CI: 4.34, 6.42, p<0.0001) and Stage 2 hypertension (Estimate = 1.70, 95% CI: 3.86, 7.77, p<0.0001). Finally, we found that noise exposure-urban interaction was consistently associated with an increase in blood pressure in elevated blood pressure (Estimate = 0.32, 95% CI: 1.19, 1.62, p<0.0001) and in Stage 2 hypertension (Estimate = 0.44, 95% CI: 1.31, 1.80, p<0.0001).

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Section: Methodsmentioning

confidence: 99%

Occupational noise exposure is associated with hypertension in China: Results from project ELEFANT

et al. 2018

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“…We utilized data sets from Project ELEFANT, a prospective study designed to examine the impact of environmental and lifestyle factors at different points in the lifecycle through three age-based cohorts (Baby, Young and Elderly ELEFANT) upon the risk of non-communicable diseases (Cayir et al, 2018;Guo et al, 2018;Xu et al, 2018;Barrow et al, 2019). A total of 124,286 participants from the Young ELEFANT cohort were used in this study, who were recruited between 2014 and 2015 through clinic visitations in…”

Section: Materials and Methods 21 Study Populationmentioning

confidence: 99%

Effect of Radiation, Organic Solvents and Vibration Occupational Exposure on the Thyroid Disease: Results from Project ELEFANT

Yuan

Osorio-Yáñez

Fang

et al. 2021

Aerosol Air Qual. Res.

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Thyroid disease is one of the leading endocrine disorders. Occupational exposure to radiation and organic solvents are known to be risk factors, but much less is known about the effect of vibration exposure on thyroid disease risk. The aim of this study was to examine associations between occupational exposure to radiation, organic solvents and vibration in relation to thyroid disease risk and thyroid stimulating hormone (TSH) levels. We utilized Project ELEFANT, comprising 124,286 participants from Tianjin, China. Medical records including thyroid disease history were collected, and TSH levels were measured in women by automated immunometric assay. In logistic models adjusted for confounders, exposure to radiation (odds ratio, OR: 1.73; 95% CI: 1.1-2.7), organic solvents (OR: 2.0; 95% CI: 1.3-2.9) and vibration (OR: 4.4; 95% CI: 2.0-8.75) were significantly associated with increased risk of thyroid disease. TSH concentrations in female participants (median: 1.95 and 95% CI: 2.45-2.77) were associated only with vibration exposure (ß: 2.80; 95% CI: 1.07-4.54). Our data showed for the first time that vibration exposure is associated with increased risk of thyroid disease and raised TSH hormone levels. If confirmed in other cohorts, thyroid examinations should be conducted in workers exposed to vibration in the workplace.

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“…; Barrow et al . ). Based on extensive health‐related data collected on the ELEFANT participants ( n > 400 000) between 2013 and 2016, we shall examine the relationships between platelet mtDNA methylation and dietary metabolites ( e.g.…”

Section: Future Studymentioning

confidence: 97%

Platelet mitochondrial DNA methylation: Markers of cardiovascular disease predisposition in overweight and obese individuals

Byun

2019

Nutrition Bulletin

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Obesity‐related non‐communicable diseases are global health issues. More than 50% of men and women are overweight or obese in the UK, which is associated with increased risk of cardiovascular disease (CVD) among other non‐communicable diseases. Early detection of the risk of CVD development within high‐risk groups is urgently needed to reduce the burden of this disease. Several mechanisms underlie the increased risk of CVD in overweight and obese individuals, yet non‐invasive molecular markers for risk prediction are not readily available. With the support of funding from the British Nutrition Foundation Drummond Pump Priming Award, we examined platelet mitochondrial DNA methylation in overweight and obese participants at baseline in relation to future CVD incidence. In this article, the findings from the project supported by the British Nutrition Foundation and future directions are described.

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Psychosocial stress is associated with benign breast disease in young Chinese women: results from Project ELEFANT

Cited by 11 publications

References 47 publications

Occupational noise exposure is associated with hypertension in China: Results from project ELEFANT

Occupational noise exposure is associated with hypertension in China: Results from project ELEFANT

Effect of Radiation, Organic Solvents and Vibration Occupational Exposure on the Thyroid Disease: Results from Project ELEFANT

Platelet mitochondrial DNA methylation: Markers of cardiovascular disease predisposition in overweight and obese individuals

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