2009
DOI: 10.3748/wjg.15.2980
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Psychosocial stress and liver disease status

Abstract: "Psychosocial stress" is an increasingly common concept in the challenging and highly-demanding modern society of today. Organic response to stress implicates two major components of the stress system, namely the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. Stress is anamnestically reported by patients during the course of disease, usually accompanied by a decline in their overall health status. As the mechanisms involving glucocorticoids and catecholamines have been deciphered, and … Show more

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Cited by 65 publications
(49 citation statements)
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“…The neuroimmunoendocrine regulation of PrP C in neutrophils and its impact upon the cytotoxic potential of this cell may help explain previous observations that behavioral stress, which modifies both the risk and the course of various diseases (51)(52)(53)(54)(55) and strongly modulates the immune system (56 -58), also affects the cytotoxic functions of neutrophils (59). Notably, the cytotoxicity of neutrophils often swings toward the production of tissue damage (15,16).…”
Section: Discussionmentioning
confidence: 78%
“…The neuroimmunoendocrine regulation of PrP C in neutrophils and its impact upon the cytotoxic potential of this cell may help explain previous observations that behavioral stress, which modifies both the risk and the course of various diseases (51)(52)(53)(54)(55) and strongly modulates the immune system (56 -58), also affects the cytotoxic functions of neutrophils (59). Notably, the cytotoxicity of neutrophils often swings toward the production of tissue damage (15,16).…”
Section: Discussionmentioning
confidence: 78%
“…Adachi et al, via the same animal models, documented the development of oxidative damages to the DNA of hepatocytes after a period of 4 days of exposure (68). With regard to human studies, the understanding of the role played by stress on the onset and progression of acute and chronic liver diseases has assumed considerable importance in the current literature (42). In a recent review concerning the main scientific investigations carried out on the subject, Chida et al concluded that psychological stress promotes the development of a liver inflammatory response that can contribute (as a cause or contributory cause) to the risk of developing and/or worsening the course of various liver diseases (41).…”
Section: Comparing the Results Of The Questionnaire Hse And Liver Parmentioning
confidence: 99%
“…These preliminary studies, pointed out how under conditions of increased stress a physiological alteration of liver functions can be observed (40) and current scientific evidence confirms that psychosocial stress may both induce primitive liver injury and induce worsening of a pre-existing liver disease (41). The understanding of the effects of stress on the onset and progression of acute and chronic liver diseases has assumed considerable importance (42) and recent studies on animals and clinical evidences in humans are trying to clarify this complex relationship (43)(44)(45). These studies were carried out in a national and international context (40,41,(43)(44)(45) but the hepatic effects of specific exposures such as those related to chronic work stress were evaluated in very few epidemiological studies (46) and the bibliographic database on the topic is seriously incomplete.…”
Section: Stress and Stress Related Diseasesmentioning
confidence: 99%
“…In recent years, the role of stress mediators in the liver pathophysiology has gained a new dimension [8, 10, 11]. Deviant increase in glucocorticoids following stress-arousal influences both food consumption and energy expenditure [12, 13].…”
Section: Introductionmentioning
confidence: 99%