Psychosocial Stress and Cardiovascular Disease

Dar, Tawseef; Radfar, Azar; Abohashem, Shady; Pitman, Roger K.; Tawakol, Ahmed; Osborne, Michael T.

doi:10.1007/s11936-019-0724-5

Cited by 149 publications

(122 citation statements)

References 122 publications

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“…restorative sleep patterns as well as learning strategies to mitigate the physiologic response to distress [148]. This is due to the fact, that accumulating evidence suggests, that chronic exposure to stressors such as nocturnal quantitative and qualitative sleep deprivation, and psychosocial stress such as loneliness or depression should be recognized as independent risk factors for the development of metabolic disorders and cardiovascular diseases [148,[158][159][160][161][162]. These disturbances are closely related to sympathoadrenergic activation, chronic upregulation of the hypothalamic-pituitary-adrenal axis and cerebral and systemic chronic low grade inflammation with downstream effects on endocrine signaling and thus reveal partial overlaps with pathophysiological mechanisms that are relevant in the development of cardiometabolic diseases such as atherosclerosis, hypertension or diabetes [148,158].…”

Section: Dietary Changesmentioning

confidence: 99%

NAFLD and cardiovascular diseases: a clinical review

et al. 2020

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Non-alcoholic fatty liver DISEASE (NAFLD) is the most common chronic liver disease in Western countries and affects approximately 25% of the adult population. Since NAFLD is frequently associated with further metabolic comorbidities such as obesity, type 2 diabetes mellitus, or dyslipidemia, it is generally considered as the hepatic manifestation of the metabolic syndrome. In addition to its potential to cause liver-related morbidity and mortality, NAFLD is also associated with subclinical and clinical cardiovascular disease (CVD). Growing evidence indicates that patients with NAFLD are at substantial risk for the development of hypertension, coronary heart disease, cardiomyopathy, and cardiac arrhythmias, which clinically result in increased cardiovascular morbidity and mortality. The natural history of NAFLD is variable and the vast majority of patients will not progress from simple steatosis to fibrosis and end stage liver disease. However, patients with progressive forms of NAFLD, including non-alcoholic steatohepatitis (NASH) and/or advanced fibrosis, as well as NAFLD patients with concomitant types 2 diabetes are at highest risk for CVD. This review describes the underlying pathophysiological mechanisms linking NAFLD and CVD, discusses the role of NAFLD as a metabolic dysfunction associated cardiovascular risk factor, and focuses on common cardiovascular manifestations in NAFLD patients.

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Section: Dietary Changesmentioning

confidence: 99%

NAFLD and cardiovascular diseases: a clinical review

et al. 2020

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“…In addition, the decreased fibrinolytic activity and increased ability to activate blood platelets play an important role. All the mentioned processes may lead to the rupture of atherosclerotic plaques and ultimately ACS [24,25]. The lost matches played by Jagiellonia Bialystok at home were found to be associated with a 27% increase in the number of male admissions for ACS.…”

Section: Discussionmentioning

confidence: 99%

It is not just a game. Do soccer matches affect cardiovascular events?

et al. 2020

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Introduction: Acute coronary syndrome (ACS) could be triggered by emotions that are often associated with watching sport events. The aim of this study was to assess the influence of soccer matches on the frequency of admissions for ACS. Material and methods: The study was based on the medical records of patients treated at the Clinical Hospital of Medical University of Bialystok from 2007 to 2018. All the official matches of the local team that took place during the study period were included in the analysis. A Poisson regression with a time effect of 0 and +1 day was used to assess the effect of matches. Results: A total of 10 529 patients admitted due to ACS from Bialystok city and county were included in the analysis. The mean age of the patients was 66.6 ±12 years, and the majority were male (62%). The mean daily number of ACS admissions was 2.4 ±1.7. Since 2007, Jagiellonia Białystok has played 451 matches in total. The comparative analysis of exciting matches showed a higher frequency of admissions due to unstable angina (UA) (1.50 ±1.55 vs. 0.71 ±0.90, p < 0.01). The lost matches played at home were associated with a 27% increase in the number of male admissions for ACS (RR = 1.27, 95% CI: 1.02-1.58, p = 0.03). Conclusions: The results achieved by the local professional soccer team are related to the incidence of ACS in the male population. Emotions caused by lost games play an important role as a triggering factor for ACS in this group.

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“…In a follow up PET/CT study, Dar and colleagues (2020) were able to show that individuals with lower AmygA, despite chronic exposure to socioeconomic or environmental stressors, enjoyed relative protection from cardiovascular disease (i.e. a > 50% decreased MACE risk within 5 years of imaging) ( Dar et al., 2019 ). This protective effect may be secondary to reduced production of bone marrow derived immune cells and less atherosclerotic inflammation.…”

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 morbidity and mortality in racial/ethnic minority populations: A window into the stress related inflammatory basis of health disparities?

Gelaye

Foster

Bhasin

et al. 2020

Brain, Behavior, & Immunity - Health

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Health disparity related to race/ethnicity has been cited as “the most serious and shameful health care issue of our time”(Peterson et al., 2018). A portion of the now recognized disproportionate impact of the COVID-19 pandemic among Black, Indigenous and People of Color (BIPOC) communities is attributable to social determinants such as socioeconomic status (SES), physical living situation, health care access, and the psychosocial factors associated with socioenvironmental circumstances such as bias, victimization, trauma and toxic stress as well as structural factors that reduce the capacity to practice physical distancing (Agurs-Collins et al., 2019). In this paper, we hypothesize that, prior to the COVID-19 pandemic, disproportionate socio-economic and environmental stressors in the BIPOC population promoted heightened stress-associated neurobiological activity (Stress-NbA). This chronic elevation in Stress-NbA results in down-stream complications of chronic stress including underactivation of anti-viral type I IFN pathway genes. This results in an increase in susceptibility to viral diseases, including coronavirus illnesses. Additionally, Stress-NbA chronically potentiates systemic inflammation (from hematopoietic system activation with myelopoiesis) increasing the prevalence of metabolic syndrome (MetS) and setting the stage for stress-related chronic non-communicable diseases (NCDs). This process was propelled by overactivation of immune cell gene expression in the nuclear factor κ-light-chain-enhancer of activated B cells (NF-kB) activation pathway and underactivation of gene expression in the anti-viral type I interferon (IFN) pathway. The higher prevalence of MetS and NCDs in minority populations turned out to be predictive of the elevated risk they would face in the presence of a highly contagious viral pandemic. The stress-related generation of a chronic non-pathogen associated molecular pattern (non-PAMP) immunoactivation state led to decreased viral immune defense and increased susceptibility to SARS-CoV-2 infection with increased risk of severe illness induced by cytokine storm syndrome (CSS).

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Psychosocial Stress and Cardiovascular Disease

Cited by 149 publications

References 122 publications

NAFLD and cardiovascular diseases: a clinical review

NAFLD and cardiovascular diseases: a clinical review

It is not just a game. Do soccer matches affect cardiovascular events?

SARS-CoV-2 morbidity and mortality in racial/ethnic minority populations: A window into the stress related inflammatory basis of health disparities?

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