Psychosocial interventions for people with both severe mental illness and substance misuse

Hunt, Glenn E.; Siegfried, Nandi; Morley, Kirsten C.; Brooke-Sumner, Carrie; Cleary, Michelle

doi:10.1002/14651858.cd001088.pub4

Cited by 83 publications

(77 citation statements)

References 365 publications

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“…4 Interestingly, 14.6% of our patients showed intrathecal OCBs and 4.6% showed a mild pleocytosis, which is comparable with previous reports, 10 but significantly below the rates reported for fullblown autoimmune encephalitis. 11 These findings may point to a possible not yet fully understood central nervous system inflammatory or immune process in schizophrenia. 10 The limitations of our study are its retrospective and open design, the use of a single-screening method and the lack of a control group and longitudinal data.…”

Section: Discussionmentioning

confidence: 98%

Absence of cerebrospinal fluid antineuronal antibodies in schizophrenia spectrum disorders

Oviedo-Salcedo

Witte

Kümpfel³

et al. 2018

Br J Psychiatry

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SummaryAntibody-mediated encephalitis has been discussed as one possible cause for isolated psychotic syndromes. Mostly based on serum samples, findings have been controversial. We present the results of a retrospective study of 124 clinically diagnosed psychotic patients without documented relevant neurological symptoms. All were tested for different antineuronal antibodies in cerebrospinal fluid (CSF) while 81 received serum testing. Antineuronal antibodies in CSF were negative across the sample. 3.7% showed low positive serum antibodies. Our findings highlight the importance of a deeper discussion about the relevance of low positive serum antibodies without concurrent findings in CSF or clinical signs for autoimmune encephalitis.Declaration of interestNone.

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Section: Discussionmentioning

confidence: 98%

Absence of cerebrospinal fluid antineuronal antibodies in schizophrenia spectrum disorders

Oviedo-Salcedo

Witte

Kümpfel³

et al. 2018

Br J Psychiatry

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“…However, external validity can be stronger in multiple case study designs, which was the choice in SUSTAIN, and can be weak in more highly ranked randomised control trials. Such weaknesses in RCT design have been exposed in a number of systematic reviews and secondary analyses [47] .…”

Section: Discussion: Addressing the Challengesmentioning

confidence: 99%

Advancing integrated care evaluation in shifting contexts: Blending implementation research with case study design in Project SUSTAIN.

Billings

Bruin

Baan

et al. 2020

Preprint

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BackgroundDespite many studies evaluating the effectiveness of integrated care, evidence remains inconsistent. There is increasing commentary pointing out the mismatch between the ability to capture the somewhat ‘illusive’ impact of integrated care initiatives and programmes, and the most appropriate way to do this. Focusing on methodology, this paper describes and critically reviews the experiences of SUSTAIN, a Horizon 2020 funded project (2015-2019) with the purpose of advancing knowledge and understanding of cross-European integrated care evaluation. SUSTAIN sought to improve integrated care initiatives for older people in seven countries, and to maximise the potential for knowledge transfer and application across Europe. The methods approach drew from implementation research, employing the participative Evidence Integration Triangle (EIT) and incorporating a mixed method, multiple embedded case study design. A core set of qualitative and quantitative indicators, alongside context and process data, were created and tested within four key project domains (person-centredness, prevention-orientation, safety and efficiency). The paper critically discusses the overall approach, highlighting the value of the EIT and case study design, and signalling the challenges of data collection with frail older people and stakeholder involvement at the sites, as well as difficulties developing the core set of indicators.ConclusionsLessons learned and recommendations for advancing integrated care evaluation are put forward that focus on the status of integrated care as a complex intervention and a process. The use of implementation research methods and case study design are recommended as an additional evaluation approach for researchers to consider, alongside suggested ways of improving methods of data collection with frail populations and cost analysis.

show abstract

Section: Discussion: Addressing the Challengesmentioning

confidence: 99%

Advancing integrated care evaluation in shifting contexts: Blending implementation research with case study design in Project SUSTAIN.

Billings

Bruin

Baan

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Despite many studies evaluating the effectiveness of integrated care, evidence remains inconsistent. There is increasing commentary pointing out the mismatch between the ability to capture the somewhat ‘illusive’ impact of integrated care initiatives and programmes, and the most appropriate way to do this. Focusing on methodology, this paper describes and critically reviews the experiences of SUSTAIN, a Horizon 2020 funded project (2015–2019) with the purpose of advancing knowledge and understanding of cross-European integrated care evaluation. SUSTAIN sought to improve integrated care initiatives for older people in seven countries, and to maximise the potential for knowledge transfer and application across Europe. The methods approach drew from implementation research, employing the participative Evidence Integration Triangle (EIT) and incorporating a mixed method, multiple embedded case study design. A core set of qualitative and quantitative indicators, alongside context and process data, were created and tested within four key project domains (person-centredness, prevention-orientation, safety and efficiency). The paper critically discusses the overall approach, highlighting the value of the EIT and case study design, and signalling the challenges of data collection with frail older people and stakeholder involvement at the sites, as well as difficulties developing the core set of indicators. Conclusions Lessons learned and recommendations for advancing integrated care evaluation are put forward that focus on the status of integrated care as a complex intervention and a process. The use of implementation research methods and case study design are recommended, alongside suggested ways of improving methods of data collection with frail populations and cost analysis.

show abstract

Psychosocial interventions for people with both severe mental illness and substance misuse

Cited by 83 publications

References 365 publications

Absence of cerebrospinal fluid antineuronal antibodies in schizophrenia spectrum disorders

Absence of cerebrospinal fluid antineuronal antibodies in schizophrenia spectrum disorders

Advancing integrated care evaluation in shifting contexts: Blending implementation research with case study design in Project SUSTAIN.

Advancing integrated care evaluation in shifting contexts: Blending implementation research with case study design in Project SUSTAIN.

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