Psychosocial impact of sport activity in neuromuscular disorders

Vita, Gian Luca; Stancanelli, Claudia; Foresta, Stefania La; Faraone, Cristina; Sframeli, Maria; Ferrero, Amanda; Fattore, Cinzia; Galbo, Rosy; Ferraro, Manfredi; Ricci, Giulia; Piccinelli, Stefano Cotti; Pizzighello, Silvia; Filosto, Massimiliano; Martinuzzi, Andrea; Padua, Luca; Trimarchi, Giuseppe; Siciliano, Gabriele; Mongini, Tiziana; Berardinelli, Angela; Vita, Giuseppe

doi:10.1007/s10072-020-04345-1

Cited by 13 publications

(15 citation statements)

References 26 publications

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“…It is known that the regular practice of physical exercises acts as a modulator of the immune system lowering the incidence, intensity of symptoms, and mortality in viral infections, which can be observed in people who are physically active [36]. The regular practice of sport activity, or physical activity, or physical exercise may represent a complementary therapy to improve mental and social well-being not only during COVID-19 pandemic [2], but also in different conditions, such as in neuromuscular disorders [37].…”

Section: Physical Exercise and Mental Health During The Pandemicmentioning

confidence: 99%

Physical exercise effects on the brain during COVID-19 pandemic: links between mental and cardiovascular health

et al. 2021

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The current pandemic was caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The quarantine period during corona virus disease 19 (COVID-19) outbreak might affect the quality of life leading thousands of individuals to diminish the daily caloric expenditure and mobility, leading to a sedentary behavior and increase the number of health disorders. Exercising is used as a non-pharmacological treatment in many chronic diseases. Here, we review the molecular mechanisms of physical exercise in COVID-19 pandemic on mental health. We also point links between exercise, mental, and cardiovascular health. The infection caused by SARS-CoV-2 affects host cells binding to angiotensin-converting enzyme-2 (ACE2), which is the receptor for SARS-CoV-2. If there is not enough oxygen supply the lungs and other tissues, such as the heart or brain, are affected. SARS-CoV-2 enhances ACE2 leading to inflammation and neuronal death with possible development of mood disorders, such as depression and anxiety. Physical exercise also enhances the ACE2 expression. Conversely, the activation of ACE2/Ang 1-7/Mas axis by physical exercise induces an antiinflammatory and antifibrotic effect. Physical exercise has beneficial effects on mental health enhancing IGF-1, PI3K, BDNF, ERK, and reducing GSK3β levels. In addition, physical exercise enhances the activity of PGC-1α/ FNDC5/Irisin pathway leading to neuronal survival and the maintenance of a good mental health. Thus, SARS-CoV-2 infection leads to elevation of ACE2 levels through pathological mechanisms that lead to neurological and cardiovascular complications, while the physiological response of ACE2 to physical exercise improves cardiovascular and mental health.

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Section: Physical Exercise and Mental Health During The Pandemicmentioning

confidence: 99%

Physical exercise effects on the brain during COVID-19 pandemic: links between mental and cardiovascular health

et al. 2021

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“…Benefits of these exercises (in particular, aerobic exercise) have been difficult to assess due to a high drop-out rate [318]. However, exercise through sport activity has been shown to significantly improve self-esteem and identity, reduce depression, and result in a greater quality of life for patients with neuromuscular disorders, including SMA-affected individuals [319]. With new FDA-approved SMN-based therapies improving the ability of SMA-affected individuals to participate in activity that demands endurance, strength, and motor skills, exercise may be an excellent, low-cost and accessible method to improve the negative psychological and emotional aspects of SMA.…”

Section: Physical Therapy Strategiesmentioning

confidence: 99%

In Search of a Cure: The Development of Therapeutics to Alter the Progression of Spinal Muscular Atrophy

2021

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Until the recent development of disease-modifying therapeutics, spinal muscular atrophy (SMA) was considered a devastating neuromuscular disease with a poor prognosis for most affected individuals. Symptoms generally present during early childhood and manifest as muscle weakness and progressive paralysis, severely compromising the affected individual’s quality of life, independence, and lifespan. SMA is most commonly caused by the inheritance of homozygously deleted SMN1 alleles with retention of one or more copies of a paralog gene, SMN2, which inversely correlates with disease severity. The recent advent and use of genetically targeted therapies have transformed SMA into a prototype for monogenic disease treatment in the era of genetic medicine. Many SMA-affected individuals receiving these therapies achieve traditionally unobtainable motor milestones and survival rates as medicines drastically alter the natural progression of this disease. This review discusses historical SMA progression and underlying disease mechanisms, highlights advances made in therapeutic research, clinical trials, and FDA-approved medicines, and discusses possible second-generation and complementary medicines as well as optimal temporal intervention windows in order to optimize motor function and improve quality of life for all SMA-affected individuals.

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“…(Respondent 68, SMA-III, age 23, female). Being able to participate in activities, speci cally physical activities and sports, has been linked to improved mental and social well-being in adolescents and young adults affected by neuromuscular disorders (Vita et al, 2020). In the video contest submissions, all participants highlighted their interests, ranging from video games to student government, attending concerts, and travel.…”

Section: Hobbies/interestsmentioning

confidence: 99%

“I have SMA, SMA doesn’t have me”- A Qualitative Snapshot Into the Challenges, Successes, and Quality of Life of Sma Adolescents and Young Adults

Mazzella

Curry

Belter

et al. 2020

Preprint

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Background: With the approval of two treatments for spinal muscular atrophy (SMA) and several promising therapies on the horizon, the SMA adolescent and young adult populations are expected to evolve in the coming years. It is imperative to understand this cohort as it exists today to provide optimal care and resources, as well as to assess possible treatment effects over time. In 2018, Cure SMA launched two initiatives geared towards understanding adolescents and young adults with SMA, ages 12-25. First, Cure SMA launched a clinical meaningfulness survey to capture information, quantitatively and qualitatively, on the quality-of-life of this population. Concurrently, Cure SMA invited SMA-affected individuals, ages 12-25, to create a three-minute video on their everyday experiences living with SMA. An inductive thematic analysis of the open-ended section in the survey along with the video contest findings are reported here.Results: Eighty-five individuals — 6 type Is, 58 type IIs, and 21 type IIIs — completed the open-ended section of the survey, while six individuals, mostly type II, participated in the SMA awareness video contest. In both settings, individuals detailed a wide variety of challenges, including but not limited to forming or maintaining close relationships, feelings of isolation, challenges with accessibility, independence, and dealing with the stigma of being perceived as mentally disabled. Individuals also discussed their successes, including but not limited to higher education enrollment and attendance, development of quality friendships, and perseverance through obstacles. Additionally, in the survey, an overwhelming number of respondents (39%) requested the creation of an SMA peer support group in efforts to connect with each other as well as collectively navigate the aforementioned challenges they face. Conclusion: Together, these findings provide a rare glimpse into the unique mindsets, challenges and motivations of SMA adolescents and young adults, via patient-reported measures instead of caregiver proxy. The adolescent and young adult age demographics assessed represent a critical transition period in life and in SMA care. No one understands the needs of an adolescent or young adult with SMA better than the individuals themselves, and it is critical to capture their insights in order to affect change.

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Psychosocial impact of sport activity in neuromuscular disorders

Cited by 13 publications

References 26 publications

Physical exercise effects on the brain during COVID-19 pandemic: links between mental and cardiovascular health

Physical exercise effects on the brain during COVID-19 pandemic: links between mental and cardiovascular health

In Search of a Cure: The Development of Therapeutics to Alter the Progression of Spinal Muscular Atrophy

“I have SMA, SMA doesn’t have me”- A Qualitative Snapshot Into the Challenges, Successes, and Quality of Life of Sma Adolescents and Young Adults

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