Psychosocial impact of hidradenitis suppurativa: a practical guide for clinicians

Weigelt, Maximillian A.; Milrad, Sara F.; Kirby, Joslyn; Lev‐Tov, Hadar

doi:10.1080/09546634.2021.1937483

Cited by 5 publications

(4 citation statements)

References 68 publications

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“…It seems that there is a need for a more holistic view of the disease. [23][24][25] Among the top 100 cited articles, there was an extensive focus on the pathogenesis of the disease, mainly on the various pathways of inflammation and a few on the connection to a bacterial skin infection. Correspondingly, there appears to be a Of all the articles, fewer than 20% researched morbidity among the pediatric population, especially adolescents.…”

Section: Discussionmentioning

confidence: 99%

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A bibliometric analysis of hidradenitis suppurativa literature over the past 50 years

Peles

Horev

2023

Int J Dermatology

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Background We aimed to describe the existing literature on hidradenitis suppurative (HS) in the last 50 years and the key processes made over time. Methods On July 27, 2022, we searched for HS studies published in the last 50 years (from 1972 to 2022) using Web of Science. The search was made using the keywords “Hidradenitis Suppurativa” and “Acne Inversa.” The data are subdivided according to publications and citations rate, country, publication year, journal and impact factor, keywords analysis of top 100 cited papers study design, and pediatric versus adults. Results In total, 5072 documents were retrieved. The annual number of HS publications has increased over the years. The manuscript with the highest citation number was by Zouboulis et al., a total of 552 citations from 2015. The manuscript with the highest citation rate per year was by Mantovani et al., with a citation rate of 70.7/year. According to keywords analysis among the top 100 cited papers, most of the articles focused on management, followed by the pathogenesis of HS. Only 805 out of 5072 (15.8%) HS articles described the disease among children. Conclusions In the current analysis, we shed light on HS's transformations over the last 50 years. In addition, we described the 100 top cited papers and other essential characteristics not examined before, such as HS research in children, gender bias research, specific pharmacological therapy with keyword analysis, comorbidities, preventative care, and publications per country after controlling for population.

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Section: Discussionmentioning

confidence: 99%

“…However, a relatively small number of studies described the psychosocial burden associated with HS (two articles mentioned the term “depression” in their keywords). It seems that there is a need for a more holistic view of the disease 23–25 …”

Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of hidradenitis suppurativa literature over the past 50 years

Peles

Horev

2023

Int J Dermatology

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“…Due to its chronic nature and frequently occurring relapses, HS has a great impact on the patients' quality of life, deeply affecting social, working, and psychological aspects [2,[7][8][9]. Therefore, early diagnosis is very important for HS patients in order to ensure the best possible course of this stigmatizing and painful disease.…”

Section: Introductionmentioning

confidence: 99%

Hidradenitis Suppurativa: Where We Are and Where We Are Going

Scala

Cacciapuoti

Garzorz‐Stark

et al. 2021

Cells

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Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease primarily affecting apocrine gland-rich areas of the body. It is a multifactorial disease in which genetic and environmental factors play a key role. The primary defect in HS pathophysiology involves follicular occlusion of the folliculopilosebaceous unit, followed by follicular rupture and immune responses. Innate pro-inflammatory cytokines (e.g., IL-1β, and TNF-α); mediators of activated T helper (Th)1 and Th17 cells (e.g., IFN-γ, and IL-17); and effector mechanisms of neutrophilic granulocytes, macrophages, and plasma cells are involved. On the other hand, HS lesions contain anti-inflammatory mediators (e.g., IL-10) and show limited activity of Th22 cells. The inflammatory vicious circle finally results in pain, purulence, tissue destruction, and scarring. HS pathogenesis is still enigmatic, and a valid animal model for HS is currently not available. All these aspects represent a challenge for the development of therapeutic approaches, which are urgently needed for this debilitating disease. Available treatments are limited, mostly off-label, and surgical interventions are often required to achieve remission. In this paper, we provide an overview of the current knowledge surrounding HS, including the diagnosis, pathogenesis, treatments, and existing translational studies.

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“…Recent studies have reported on the increased prevalence of anxiety, depression, and suicidality among patients with HS [ 5 ]. These psychological conditions are indicative of a poor QoL [ 6 ] and highlight the importance of incorporating patient-focused outcome measures in HS research. Both the US Federal Drug Administration and European Medicines Agency have recommended the evidence-based use of patient-reported outcome measures (PROMs) in clinical trials and have emphasized their importance [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Trends in Hidradenitis Suppurativa Disease Severity and Quality of Life Outcome Measures: Scoping Review

Jalal¹

2021

JMIR Dermatol

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Background Although there has been an increase in the number of randomized controlled trials evaluating treatment efficacy for hidradenitis suppurativa (HS), instrument measurements of disease severity and quality of life (QoL) are varied, making the compilation of data and comparisons between studies a challenge for clinicians. Objective We aimed to perform a systematic literature search to examine the recent trends in the use of disease severity and QoL outcome instruments in randomized controlled trials that have been conducted on patients with HS. Methods A scoping review was conducted in February 2021. The PubMed, Embase, Web of Science, and Cochrane databases were used to identify all articles published from January 1964 to February 2021. In total, 41 articles were included in this systematic review. Results The HS Clinical Response (HiSCR) score (18/41, 44%) was the most commonly used instrument for disease severity, followed by the Sartorius and Modified Sartorius scales (combined: 16/41, 39%). The Dermatology Life Quality Index (18/41, 44%) and visual analogue pain scales (12/41, 29%) were the most commonly used QoL outcome instruments in HS research. Conclusions Randomized controlled trials conducted from 2013 onward commonly used the validated HiSCR score, while older studies were more heterogeneous and less likely to use a validated scale. A few (6/18, 33%) QoL measures were validated instruments but were not specific to HS; therefore, they may not be representative of all factors that impact patients with HS. Trial Registration National Institute of Health Research PROSPERO CRD42020209582; https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020209582

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Psychosocial impact of hidradenitis suppurativa: a practical guide for clinicians

Cited by 5 publications

References 68 publications

A bibliometric analysis of hidradenitis suppurativa literature over the past 50 years

A bibliometric analysis of hidradenitis suppurativa literature over the past 50 years

Hidradenitis Suppurativa: Where We Are and Where We Are Going

Trends in Hidradenitis Suppurativa Disease Severity and Quality of Life Outcome Measures: Scoping Review

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