Psychosocial, health and demographic characteristics of quality of life among patients with acute myeloid leukemia and malignant lymphoma who underwent autologous hematopoietic stem cell transplantation

Abstract

CONTEXT AND OBJECTIVE: This study evaluated the effect of selected psychosocial, health and demographic characteristics of quality of life (QOL) among patients treated with autologous hematopoietic stem cell transplantation (HSCT). DESIGN AND SETTING: This was a retrospective study at Charles University Hospital, Hradec Kralove. METHODS: The Czech version of the international generic European Quality-of-Life questionnaire (EQ-5D) was applied to evaluate QOL among patients with acute myeloid leukemia (AML) and malignant Hodgkin’s and non-Hodgkin’s lymphoma (ML). The total number of respondents was 36: 12 with AML (seven males and five females) and 24 with ML (11 males and 13 females). The mean age of AML respondents was 46 years and the mean age of ML respondents was 44.5 years. RESULTS: Age, smoking status and education level had statistically significant effects on QOL among AML respondents (p < 0.05), and age had a statistically significant effect on QOL among ML respondents (p < 0.05). The overall QOL among AML and ML respondents was generally good: the mean EQ-5D score among AML respondents was 71.5% and among ML respondents it was 82.7%. CONCLUSION: The QOL among AML and ML respondents treated with autologous HSCT was good. However, patients more than 50 years old, smokers and patients with lower education levels presented worse QOL. These findings need to be better evaluated in longitudinal studies, using large samples.

Are psychosocial factors associated with quality of life in patients with haematological cancer? A critical review of the literature

“…Among these articles, 14 met the inclusion criteria and were included in our review. Nine studies were from ‘PsycInfo’ , four were from ‘Science Direct’ , and one was from ‘Medline’ . Citations were from four different psychology journals ( Psycho‐Oncology , Journal of Psychosocial Oncology , Journal of Psychosomatic Research and Mental Health, Religion and Culture ) and six medical journals ( Quality of Life Research , Support Care Cancer , Reports of Practical Oncology & Radiotherapy , Blood Reviews , Sao Paulo Medical Journal and Leukaemia Research ) published between 1999 and 2010.…”

“…One paper presented the level of evidence I and 13 level II . Two studies were longitudinal , 12 were cross‐sectional , and four were retrospective . Five studies were based on a large sample size , whereas 9 papers concerned small samples .…”

“…Two studies were longitudinal , 12 were cross‐sectional , and four were retrospective . Five studies were based on a large sample size , whereas 9 papers concerned small samples . In eight studies, the authors used standardized tools .…”

“…Five studies were based on a large sample size , whereas 9 papers concerned small samples . In eight studies, the authors used standardized tools . All instruments assessed the physical, psychological and social components of QoL: the QLQ‐C30 , QoL‐CS , SEIQoL , EQ‐5D , FACT‐G , FACIT‐G , SF‐36 , SF‐12[20], SEIQoL‐DW , FACIT‐Sp‐12‐C for the spiritual domain.…”

Distress and unmet needs during treatment and quality of life in early cancer survivorship: A longitudinal study of haematological cancer patients

“…Multivariate associations between each T2 outcome variable (Overall FACT‐G, PWB, SWB, EWB and FWB subscales) and T1 anxiety, depression and unmet needs domains were examined using multiple linear regressions. The multivariable models controlled for potential confounders of age, sex, time since diagnosis, region of residence, cancer type, perceived health at T1 and chemotherapy received as past studies, have been found associations between these variables and QoL in haematological cancer …”