Psychosocial Factors Are More Important Than Disease Activity in Determining Gastrointestinal Symptoms and Health Status in Adults at a Celiac Disease Referral Center

Dorn, Spencer D.; Hernandez, Lincoln; Minaya, Maria T.; Morris, Carolyn; Hu, Yan; Lewis, Suzanne K.; Leserman, Jane; Bangdiwala, Shrikant I.; Green, Peter H.R.; Drossman, Douglas A.

doi:10.1007/s10620-010-1342-y

Cited by 45 publications

(39 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Taavela et al [22] reported a significant correlation between the degree of small bowel mucosal damage based on villous height/ crypt depth ratio, anti-tTG serum antibodies, and patient-reported gastrointestinal symptoms. On the contrary, no significant correlation between clinical presentation and mucosal damage in CD was found in a number of other studies [23][24][25], but most of these studies focused on classical versus atypical/silent presentation, while the clinical spectrum of disease may not always fit these definitions.…”

Section: Discussionmentioning

confidence: 88%

Relationships between Clinical Presentation, Serology, Histology, and Duodenal Deposits of Tissue Transglutaminase Antibodies in Pediatric Celiac Disease

Loberman-Nachum¹,

Schvimer²,

Avivi³

et al. 2018

Dig Dis

View full text Add to dashboard Cite

Background: The clinical, histological, and serological spectrum of celiac disease (CD) vary widely. We aimed to examine relationships between symptoms, serum anti-tissue transglutaminase antibodies (tTG) levels, mucosal damage, and mucosal anti-tTG deposits in pediatric CD. Methods: A retrospective single-center, cohort study of children referred for endoscopy with suspected CD during 2011–2014. We retrieved the clinical data, blindly reviewed duodenal biopsies, and performed immunohistochemical staining for anti-tTG deposits. Patients were classified as monosymptomatic or polysymptomatic. Mucosal anti-tTG deposits were classified according to the location of deposits, dominant intensity, maximal intensity, and percentage of stained area. Results: Of 252 patients with confirmed CD, complete data were available for 100: 37 males in the age range 1.3–16.7 with median 4.0 years. Monosymptomatic patients (n = 54) presented at an older age than polysymptomatic patients (1.3–15.5, median 8.1 vs. 1.3–16.7, median 6.3 years, p = 0.026). Marsh 2–3c was more prevalent in polysymptomatic patients (93 vs. 78%, p = 0.028). The intensity of mucosal anti-tTG deposits correlated with serum anti-tTG levels but not with the clinical presentation. Conclusions: Multiple symptoms and high serum anti-tTG antibody levels correlated with mucosal damage in children with CD. The role of immunohistochemical staining for intestinal anti-tTG mucosal deposits in the diagnosis of borderline CD is not yet established.

show abstract

Section: Discussionmentioning

confidence: 88%

Relationships between Clinical Presentation, Serology, Histology, and Duodenal Deposits of Tissue Transglutaminase Antibodies in Pediatric Celiac Disease

Loberman-Nachum¹,

Schvimer²,

Avivi³

et al. 2018

Dig Dis

View full text Add to dashboard Cite

show abstract

“…These types of treatment are encouraging results in phase II and III studies and do not depend on patient compliance to the diet (3) . CD, like most chronic diseases, has a negative impact on the quality of life (QOL) of the patient, both for its clinical manifestations that are variable for each individual, and by food restriction that complicates, among other things, interpersonal relationships (8) .…”

mentioning

confidence: 99%

Quality of Life Evaluation in Celiac Patients From Southern Brazil

Castilhos

Gonçalves

Silva

et al. 2015

Arq. Gastroenterol.

View full text Add to dashboard Cite

BackgroundRestrictions imposed by the gluten-free diet generate large changes in the daily habits of the celiac patient, causing a negative impact on quality of life.ObjetiveThis study aimed to evaluate the quality of life of patients with celiac disease on a capital in Southern Brazil.MethodsPatients older than 18 years were included, with confirmed celiac disease for at least 60 days in the period from June to October 2013. A validated questionnaire, with specific questions to assess the patient’s quality of life celiac was applied. A total score ranged from 20 to 100 points; the higher the score, worse quality of life.ResultsA total of 103 questionnaires were evaluated, 96 (93.2%) female, with average score 56.6±12.35 (28 to 88 points). The comparison between the questionnaire scores and family income was not significant (P=0.139). Patients diagnosed less than 1 year have poorer quality of life than those with more than 10 years (P=0.063). Patients older than 60 years had better quality of life compared with the younger ones (P=0.04).ConclusionThere was no association between quality of life and factors such as family income, length of diet and age at diagnosis. Chronological age greater than 60 years has positively influenced the quality of life of celiac patients.

show abstract

“…Psychiatric distress may also arise along with CD diagnosis. Previous research (5) have shown psychological symptoms and negative impact on the patient's quality of life and adherence of a gluten-free diet. In the United States, a study performed on 101 adult patients concluded that psychosocial factors have a stronger effect on patient's health and gastronomical symptoms incidence than the disease activity as discovered by serologists and historical data.…”

Section: Introductionmentioning

confidence: 98%

The psychosocial impacts caused by diagnosis and treatment of Coeliac Disease

Rocha

Gandolfi

Santos

2016

Rev. esc. enferm. USP

View full text Add to dashboard Cite

Objective:To comprehend the psychosocial effects that Coeliac Disease diagnosis entails. Method: Qualitative study, achieved through semi-structured interviews, analyzed in accordance to the Association of ideas map Technique. A total 12 recently-diagnosed patients from the Centro de diagnóstico, tratamento e apoio ao paciente com doença celíaca (Coeliac Disease Prevention, Support and Treatment Diagnose Centre) from the Hospital Universitário de Brasília (University Hospital of Brasilia) were enrolled for the study, between the years of 2013 and 2014. Results: The interviewed patients presented negative impacts in three categories: psychoaffective, family and social relationships, indicating issues with social readaptation once the treatment had started, as well as difficulty coping with a gluten free diet. Conclusion: Coeliac Disease holds substantial impact on psychological functions, family and social relationships to diagnosed patients, requiring a clinical biopsychological assistance for better adherence to treatment and patients quality of life. DESCRIPTORS

show abstract

Psychosocial Factors Are More Important Than Disease Activity in Determining Gastrointestinal Symptoms and Health Status in Adults at a Celiac Disease Referral Center

Abstract: In patients presenting to a CD referral center, psychosocial factors more strongly affect health status and GI symptoms than disease measures.

Cited by 45 publications

References 48 publications

Relationships between Clinical Presentation, Serology, Histology, and Duodenal Deposits of Tissue Transglutaminase Antibodies in Pediatric Celiac Disease

Relationships between Clinical Presentation, Serology, Histology, and Duodenal Deposits of Tissue Transglutaminase Antibodies in Pediatric Celiac Disease

Quality of Life Evaluation in Celiac Patients From Southern Brazil

The psychosocial impacts caused by diagnosis and treatment of Coeliac Disease

Contact Info

Product

Resources

About