Psychosocial Factors and Inflammation in the Multi-Ethnic Study of Atherosclerosis

Ranjit, Nalini; Diez‐Roux, Ana V.; Shea, Steven; Cushman, Mary; Seeman, Teresa E.; Jackson, Sharon; Ni, Hanyu

doi:10.1001/archinte.167.2.174

Cited by 230 publications

(180 citation statements)

References 33 publications

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“…Insufficient sleep is concluded to increase the concentration of cytokines and inflammatory mediators [16,27]. Findings that chronic stress, obesity and smoking also increase the concentration of inflammatory factors [39] are in line with the hypothesis that inflammation may mediate the relation among insufficient quality and quantity of sleep, other psychological risk factors, and neck, shoulder and low back disorders. Other mechanisms by which insufficient quantity and quality of sleep may increase the likelihood of musculoskeletal pains are the inhibition of muscle relaxation and activation of the sympathetic nervous system via distress and strain, thereby increasing muscle tone and increasing the risk for pain and injuries of muscular origin.…”

Section: Discussionsupporting

confidence: 70%

Is insufficient quantity and quality of sleep a risk factor for neck, shoulder and low back pain? A longitudinal study among adolescents

et al. 2009

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The quantity and quality of adolescents' sleep may have changed due to new technologies. At the same time, the prevalence of neck, shoulder and low back pain has increased. However, only a few studies have investigated insufficient quantity and quality of sleep as possible risk factors for musculoskeletal pain among adolescents. The aim of the study was to assess whether insufficient quantity and quality of sleep are risk factors for neck (NP), shoulder (SP) and low back pain (LBP). A 2-year followup survey among adolescents aged 15-19 years was (2001)(2002)(2003) carried out in a subcohort of the Northern Finland Birth Cohort 1986 (n = 1,773). The outcome measures were 6-month period prevalences of NP, SP and LBP. The quantity and quality of sleep were categorized into sufficient, intermediate or insufficient, based on average hours spent sleeping, and whether or not the subject suffered from nightmares, tiredness and sleeping problems. The odds ratios (OR) and 95% confidence intervals (CI) for having musculoskeletal pain were obtained through logistic regression analysis, adjusted for previously suggested risk factors and finally adjusted for specific pain status at 16 years. The 6-month period prevalences of neck, shoulder and low back pain were higher at the age of 18 than at 16 years. Insufficient quantity or quality of sleep at 16 years predicted NP in both girls (OR 4.4; CI 2.2-9.0) and boys (2.2; 1.2-4.1). Similarly, insufficient sleep at 16 years predicted LBP in both girls (2.9; 1.7-5.2) and boys (2.4; 1.3-4.5), but SP only in girls (2.3; 1.2-4.4). After adjustment for pain status, insufficient sleep at 16 years predicted significantly only NP (3.2; 1.5-6.7) and LBP (2.4; 1.3-4.3) in girls. Insufficient sleep quantity or quality was an independent risk factor for NP and LBP among girls. Future studies should test whether interventions aimed at improving sleep characteristics are effective in the prevention and treatment of musculoskeletal pain.

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Section: Discussionsupporting

confidence: 70%

Is insufficient quantity and quality of sleep a risk factor for neck, shoulder and low back pain? A longitudinal study among adolescents

et al. 2009

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“…66 In a cross-sectional study of 6814 participants in the Multi-Ethnic Study of Atherosclerosis (MESA), higher levels of psychosocial stress, measured as cynical distrust and chronic stress, were associated with higher levels of CRP, and IL-6. 67 Kulenovic examined plasma lipid levels in relation to posttraumatic stress disorder (PTSD) in a study of male war veterans in Bosnia 68 and observed significantly lower levels of HDL among those veterans suffering from PTSD compared to those who were not. Other studies in civilian populations 67,69 have found direct associations between levels of psychosocial stress and triglycerides, A1C, and inverse associations with HDL.…”

Section: Discussionmentioning

confidence: 99%

“…67 Kulenovic examined plasma lipid levels in relation to posttraumatic stress disorder (PTSD) in a study of male war veterans in Bosnia 68 and observed significantly lower levels of HDL among those veterans suffering from PTSD compared to those who were not. Other studies in civilian populations 67,69 have found direct associations between levels of psychosocial stress and triglycerides, A1C, and inverse associations with HDL. Higher levels of education might be expected to be associated with lower levels of stress in that those with more education may possess the resources needed to successfully cope with stressful neighborhood conditions.…”

Section: Discussionmentioning

confidence: 99%

Neighborhood Socioeconomic Status in Relation to Serum Biomarkers in the Black Women’s Health Study

et al. 2016

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Lower neighborhood socioeconomic status (SES) is associated with higher cardiovascular disease (CVD) risk. Black women have a higher CVD risk and are more likely to live in poor neighborhoods than white women. We examined the association of neighborhood SES with several CVD biomarkers using data from the Black Women's Health Study (BWHS), a follow-up study of US black women reporting high levels of education and income. Blood specimens of 418 BWHS participants were assayed for Creactive protein (CRP), hemoglobin A1C (hgA1C), and high-density lipoprotein (HDL) cholesterol. US Census block group data were linked to the women's addresses to reflect neighborhood SES. Multivariable-adjusted mixed linear regression models that adjusted for person-level SES and for cardiovascular risk factors were used to assess CRP, hgA1C, and HDL levels in relation to quintiles of neighborhood SES. Women living in the poorest neighborhoods had the least favorable biomarker levels. As neighborhood SES increased, CRP decreased (P for trend = 0.01), hgA1C decreased (P for trend = 0.07), and HDL increased (P for trend = 0.19). These associations were present within strata of individual educational level. The present findings suggest that neighborhood environments may affect physiological processes within residents independently of individual SES.

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“…(Dentino et al, 1999;Penninx et al, 2003;Tiemeier et al, 2003;Ford, Erlinger, 2004;Liukkonen et al, 2006;Cyranowski et al, 2007;Dantzer, Kelley, 2007;Ranjit et al, 2007;Bremmer et al, 2008) The cognitive symptoms of depression can be considered an indicator of early stages of clinically diagnosed depression. (Fogel et al, 2006) Thus, our results suggest that inflammation plays a role as an initiator and contributor to the progression of depression rather than contributing to the later stages of depression development.…”

Section: Inflammation As a Predictor Of Depressive Symptomsmentioning

confidence: 99%

“…(Danesh et al, 2004) Both experimental and epidemiological research have found that depressed people have higher plasma levels of inflammatory markers. (Dentino et al, 1999;Penninx et al, 2003;Tiemeier et al, 2003;Ford, Erlinger, 2004;Liukkonen et al, 2006;Cyranowski et al, 2007;Dantzer, Kelley, 2007;Ranjit et al, 2007;Bremmer et al, 2008) However, experimental research is based on small clinical samples, and previous epidemiological research, despite large samples and thorough covariate assessment, is cross-sectional. Generally these studies have examined short-term associations between depression and inflammation, while examination of longer term associations is scarce.…”

Section: Introductionmentioning

confidence: 99%

Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study

et al. 2008

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Background-A lack of longitudinal studies has made it difficult to establish the direction of associations between circulating concentrations of low-grade chronic inflammatory markers, such as C-reactive protein and interleukin-6, and cognitive symptoms of depression. The present study sought to assess whether C-reactive protein and interleukin-6 predict cognitive symptoms of depression or whether these symptoms predict inflammatory markers.

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Psychosocial Factors and Inflammation in the Multi-Ethnic Study of Atherosclerosis

Cited by 230 publications

References 33 publications

Is insufficient quantity and quality of sleep a risk factor for neck, shoulder and low back pain? A longitudinal study among adolescents

Is insufficient quantity and quality of sleep a risk factor for neck, shoulder and low back pain? A longitudinal study among adolescents

Neighborhood Socioeconomic Status in Relation to Serum Biomarkers in the Black Women’s Health Study

Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study

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