Psychosocial factors and clinical evolution in HIV-1 infection: A longitudinal study

Solano, Luigi; Costa, Massimo; Salvati, Simona; Coda, Rosamaria; Aiuti, F; Mezzaroma, Ivano; Bertini, Mario

doi:10.1016/0022-3999(93)90122-v

Cited by 93 publications

(68 citation statements)

References 20 publications

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“…Coping strategies were assessed using the COPE (40), a 24-item scale, modified for HIV populations, which assesses the endorsement of each of 12 cognitive and behavioral coping strategies. Two subscales, denial and behavioral disengagement, were combined for an avoidant coping composite because of previous work relating them to disease outcomes in HIV (4,11,14). Life event stress was assessed using the Sarason et al (41) life events scale sum of the weighted (−3 to +3) negative life events excluding health related events.…”

Section: Psychosocial Measuresmentioning

confidence: 99%

“…Similarly, stress has predicted faster CD4 cell decline (9,10), clinical symptoms (11,12), and progression to AIDS (3,4). Longitudinal studies of coping found that denial predicts greater CD4 decline (11), progression to AIDS (11,13,14), and mortality (11). Conversely, active coping predicted decreased clinical progression (15), AIDS (16), and lower mortality (17).…”

Section: Introductionmentioning

confidence: 99%

“…Conversely, active coping predicted decreased clinical progression (15), AIDS (16), and lower mortality (17). Mixed results have been found in the literature for social support, with some studies showing higher social support predicting slower disease progression to AIDS (4), less rapid decline in CD4 cells (18), slower symptom onset (4,14), and longer survival (7). However, others found either no relationship between social support and disease progression (19) or higher social support predicting faster decline in CD4 (20).…”

Section: Introductionmentioning

confidence: 99%

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Psychosocial Factors Predict CD4 and Viral Load Change in Men and Women With Human Immunodeficiency Virus in the Era of Highly Active Antiretroviral Treatment

Ironson

O’Cleirigh

Fletcher

et al. 2005

Psychosomatic Medicine

306

245

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Objective-Most previous longitudinal studies demonstrating relationships between psychosocial variables and human immunodeficiency virus (HIV) disease progression utilized samples of gay men accrued before the era of highly active antiretroviral treatment (HAART), without including viral load (VL) as an indicator of disease progression or assessing the impact of medication adherence. This study sought to determine whether psychosocial variables would predict both CD4 and VL changes in a diverse sample assessed entirely during the era of HAART and accounting for adherence effects.Methods-This longitudinal study assessed a multiethnic HIV+ sample (n = 177) of men and women in the midrange of illness (CD4 number between 150 and 500; no previous acquired immunodeficiency syndrome [AIDS]-defining symptom) every 6 months for 2 years. Hierarchical linear modeling was used to model change in CD4 and VL controlling for sociodemographics (age, gender, ethnicity, education) and medical variables (baseline CD4/VL, antiretroviral medications at each time point, adherence).Results-Baseline depression, hopelessness, and education predicted the slope of CD4 and VL. Avoidant coping and life event stress predicted VL change. Cumulative variables produced stronger relationships (depression, avoidant coping, and hopelessness with CD4/VL slope and life events stress with VL slope). High cumulative depression and avoidant coping were associated with approximately twice the rate of decline in CD4 as low scorers and greater relative increases in VL. Social support was not significantly related to CD4 or VL slope.Conclusions-Psychosocial factors contribute significantly to the variance in HIV disease progression (assessed through CD4 number and VL) in a diverse sample, accounting for adherence and do so in the era of HAART.

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Section: Psychosocial Measuresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Psychosocial Factors Predict CD4 and Viral Load Change in Men and Women With Human Immunodeficiency Virus in the Era of Highly Active Antiretroviral Treatment

Ironson

O’Cleirigh

Fletcher

et al. 2005

Psychosomatic Medicine

306

245

View full text Add to dashboard Cite

show abstract

“…In addition, a metaanalysis conducted by Zorilla, et al similarly found no psychosocial predictors of HIV progression (Zorrilla, McKay, Luborsky, & Schmidt, 1996). Finally, Solano et al, (1993) reported several psychosocial variables associated with disease progression in PLWH with poorer immune functioning, although these were not strong predictors for those with higher CD4 counts.…”

Section: Discussionmentioning

confidence: 92%

“…Social support may be the most frequently tested predictor of HIV-related health outcomes. Several studies have found significant positive associations between support and immunologic response or HIV symptoms (Ashton et al, 2005;Solano et al, 1993;Theorell et al, 1995). Other research has not found a direct relationship between social support and either biomarkers or clinical evidence of HIV disease progression (Luigi Solano et al, 2002;Thornton et al, 2000), although these studies show more evidence of effects of various psychosocial factors on clinical and immunologic disease progression than directly on VL.…”

Section: Chapter IV Transition To Manuscriptmentioning

confidence: 99%

The Influence of Neurocognitive Impairment, Alcohol and other Drug (AOD) Use, and Psychosocial Factors on Antiretroviral Treatment Adherence, Service Utilization and Viral Load Among HIV-Seropositive Adults

Attonito¹

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Coping and Social Support

Manne

2003

Handbook of Psychology

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Coping and social support are among the most widely written about and researched topics in health psychology. Both constructs have been hypothesized as reasons why particular individuals are at increased risk for developing illnesses such as cardiovascular disease and cancer and why some individuals do not adapt well once they develop a disease. More recently, coping and social support have been linked with disease course and survival. In this chapter, I review theories of coping, definitions of social support, evidence supporting the role of coping and social support in health and psychological outcomes, theoretical and methodological challenges to both areas of research, and directions for future research.

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Psychosocial factors and clinical evolution in HIV-1 infection: A longitudinal study

Cited by 93 publications

References 20 publications

Psychosocial Factors Predict CD4 and Viral Load Change in Men and Women With Human Immunodeficiency Virus in the Era of Highly Active Antiretroviral Treatment

Psychosocial Factors Predict CD4 and Viral Load Change in Men and Women With Human Immunodeficiency Virus in the Era of Highly Active Antiretroviral Treatment

The Influence of Neurocognitive Impairment, Alcohol and other Drug (AOD) Use, and Psychosocial Factors on Antiretroviral Treatment Adherence, Service Utilization and Viral Load Among HIV-Seropositive Adults

Coping and Social Support

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