Psychosocial factors and cancer incidence (PSY‐CA): Protocol for individual participant data meta‐analyses

Tuijl, Lonneke A. van; Voogd, Adri C.; Graeff, Alexander de; Hoogendoorn, Adriaan W.; Ranchor, Adelita V.; Pan, Kuan‐Yu; Basten, Maartje; Lamers, Femke; Geerlings, Mirjam I.; Abell, Jessica; Awadalla, Philip; Bakker, Marije F.; Beekman, Aartjan; Bjerkeset, Ottar; Boyd, Andy; Cui, Yunsong; Galenkamp, Henrike; Garssen, Bert; Hellingman, Sean; Huisman, Martijn; Huss, Anke; Keats, Melanie R.; Kok, A.; Luik, Annemarie I.; Noisel, Nolwenn; Onland‐Moret, N. Charlotte; Payette, Yves; Penninx, Brenda W. J. H.; Portengen, Lützen; Rissanen, Ina; Roest, Annelieke M.; Rosmalen, Judith; Ruiter, Rikje; Schoevers, Robert A.; Soave, David; Spaan, M.; Steptoe, Andrew; Stronks, Karien; Sund, Erik R.; Sweeney, Ellen; Teyhan, Alison; Vaartjes, Ilonca; Willik, Kimberly D. van der; Leeuwen, Flora E. van; Petersen, Rutger van; Visseren, Frank L J; Vermeulen, Roel; Dekker, Joost

doi:10.1002/brb3.2340

Cited by 12 publications

(19 citation statements)

References 89 publications

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“…Initially, we had planned to report univariable models. 10 However, the conclusions were very similar to those of the minimally adjusted models and therefore we do not report these results. Furthermore, we had initially planned to run subgroup analyses that looked at differences between cancer stages at diagnosis.…”

Section: Changes From Protocolmentioning

confidence: 72%

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Depression, anxiety, and the risk of cancer: An individual participant data meta‐analysis

van Tuijl,

Basten,

Pan

et al. 2023

Cancer

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BackgroundDepression and anxiety have long been hypothesized to be related to an increased cancer risk. Despite the great amount of research that has been conducted, findings are inconclusive. To provide a stronger basis for addressing the associations between depression, anxiety, and the incidence of various cancer types (overall, breast, lung, prostate, colorectal, alcohol‐related, and smoking‐related cancers), individual participant data (IPD) meta‐analyses were performed within the Psychosocial Factors and Cancer Incidence (PSY‐CA) consortium.MethodsThe PSY‐CA consortium includes data from 18 cohorts with measures of depression or anxiety (up to N = 319,613; cancer incidences, 25,803; person‐years of follow‐up, 3,254,714). Both symptoms and a diagnosis of depression and anxiety were examined as predictors of future cancer risk. Two‐stage IPD meta‐analyses were run, first by using Cox regression models in each cohort (stage 1), and then by aggregating the results in random‐effects meta‐analyses (stage 2).ResultsNo associations were found between depression or anxiety and overall, breast, prostate, colorectal, and alcohol‐related cancers. Depression and anxiety (symptoms and diagnoses) were associated with the incidence of lung cancer and smoking‐related cancers (hazard ratios [HRs], 1.06–1.60). However, these associations were substantially attenuated when additionally adjusting for known risk factors including smoking, alcohol use, and body mass index (HRs, 1.04–1.23).ConclusionsDepression and anxiety are not related to increased risk for most cancer outcomes, except for lung and smoking‐related cancers. This study shows that key covariates are likely to explain the relationship between depression, anxiety, and lung and smoking‐related cancers.Preregistration numberhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=157677.

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Section: Changes From Protocolmentioning

confidence: 72%

“…Given the number of meta-analyses conducted that increases the likelihood of type I errors, we focused our conclusions on consistent patterns of results, as stated in the PSY-CA protocol. 10…”

Section: Stage 2: Meta-analysesmentioning

confidence: 99%

Depression, anxiety, and the risk of cancer: An individual participant data meta‐analysis

van Tuijl,

Basten,

Pan

et al. 2023

Cancer

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“…Matching with NCR data was performed within a previous project, 17 and permission from NCR was obtained to use these cancer‐related variables for the current study. Only tumors diagnosed prior to the baseline assessment and those labeled as malignant were included.…”

Section: Methodsmentioning

confidence: 99%

“…Answer categories 3 (just as much as I like) and 4 (more than I like) were combined to represent sufficient support. 26 A higher sum score indicates more supportive emotional transactions (SSQT, range [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] and more satisfaction with the support (SSQS, range 5-15). Religiosity was assessed in terms of whether one was raised according to a specific religion, one's current religion and the frequency of practicing ones religion (How often have you attended a religious service in the past 6 months (in a Church, mosque, synagogue, etc.)?…”

Section: Putative Sociocultural Correlatesmentioning

confidence: 99%

Emotional distress in cancer survivors from various ethnic backgrounds: Analysis of the multi‐ethnic HELIUS study

et al. 2023

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PurposeInsight into emotional distress of cancer survivors from ethnic minority groups in Europe is scarce. We aimed to compare distress levels of survivors from ethnic minorities to that of the majority population, determine whether the association between having cancer (yes vs. no) and distress differs among ethnic groups and investigate sociocultural correlates of distress.MethodsCross‐sectional data were derived from HELIUS, a multi‐ethnic cohort study conducted in the Netherlands. Of 19,147 participants, 351 were diagnosed with cancer (n = 130 Dutch, n = 75 African Surinamese, n = 53 South‐Asian Surinamese, n = 43 Moroccan, n = 28 Turkish, n = 22 Ghanaian). Distress (PHQ‐9, MCS‐12) and correlates were assessed by self‐report. Cancer‐related variables were derived from the Netherlands Cancer Registry.ResultsSurvivors were on average 7 years post‐diagnosis. Survivors from South‐Asian Surinamese, Moroccan, Turkish and Ghanaian origin reported more distress than survivors from Dutch origin (effect sizerange: 0.44–1.17; adjusted models). The association between having cancer or not with distress differed in direction between Dutch and the non‐Dutch ethnic groups: Non‐Dutch cancer patients tended to have more distress than their cancer‐free peers, whereas Dutch cancer patients tended to have less distress than their cancer‐free peers. For Moroccan and Turkish patients, the acculturation style of separation/marginalization, compared to integration/assimilation, was associated with higher depressive symptoms. In analyses pooling data from all ethnic minorities, lower health literacy, lower emotional support satisfaction and younger age at the time of migration were associated with higher depressive symptoms. Lower health literacy, fewer emotional support transactions, and more frequent attendance at religious services were associated with worse mental health.ConclusionCancer survivors from ethnic minorities experience more distress than those from the majority population. Culturally sensitive supportive care should be considered.

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“…Previous studies have indicated that neuroticism is significantly associated with various Axis I and II mental disorders [5][6][7]. Moreover, increasing evidence has shown correlations between neuroticism and physical problems, such as cardiovascular diseases [8,9], cancers, [10,11] and allergic diseases [12].…”

Section: Introductionmentioning

confidence: 99%

Dissecting the Association of Genetically Predicted Neuroticism with Coronary Artery Disease: A Two-Sample Mendelian Randomization Study

Yan

Zhu

Xie

et al. 2022

JPM

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Background: Observational studies on the association between neuroticism and coronary artery disease (CAD) are still rare, and the results of existing studies are not consistent. The present study aimed to explore causal associations of neuroticism with CAD. Methods: The summary-level data of GWAS for neuroticism and 12 items used to assess neuroticism were extracted from the UK Biobank, and included up to 380,506 participants. The general data for CAD were obtained from the CARDIoGRAMplusC4D consortium, which assembled 60,801 CAD patients and 123,504 non-cases. Single-nucleotide polymorphisms associated with neuroticism and 12 items at genome-wide significance were explored as instrumental variables. Two-sample Mendelian randomization (TSMR) analyses were performed to evaluate causal associations amongst the genetically predicted neuroticism and 12 items with CAD. Results: The present TSMR study did not reveal the genetic association of neuroticism with CAD. The calculated ORs for CAD using inverse-variance weighted, weighted median, and MR-Egger analysis were 1.12 (p-value = 0.187), 0.99 (p-value = 0.943), and 0.82 (p-value = 0.683), respectively. Further TSMR analysis of 12 dichotomous items for assessing neuroticism suggested that mood swings genetically increased the risk of CAD (OR = 1.67, p-value < 0.001). Conclusions: This study reported no genetically causal association of neuroticism with CAD. The present study also found that mood swings may genetically increase the risk of CAD. These findings may highlight the potential of mood control as a preventive measure for CAD.

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Psychosocial factors and cancer incidence (PSY‐CA): Protocol for individual participant data meta‐analyses

Cited by 12 publications

References 89 publications

Depression, anxiety, and the risk of cancer: An individual participant data meta‐analysis

Depression, anxiety, and the risk of cancer: An individual participant data meta‐analysis

Emotional distress in cancer survivors from various ethnic backgrounds: Analysis of the multi‐ethnic HELIUS study

Dissecting the Association of Genetically Predicted Neuroticism with Coronary Artery Disease: A Two-Sample Mendelian Randomization Study

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