2023
DOI: 10.1101/2023.10.06.559575
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Psychosocial experiences are associated with human brain mitochondrial biology

Caroline Trumpff,
Anna S Monzel,
Carmen Sandi
et al.

Abstract: Psychosocial experiences affect brain health and aging trajectories, but the molecular pathways underlying these associations remain unclear. Normal brain function relies heavily on energy transformation by mitochondria oxidative phosphorylation (OxPhos), and two main lines of evidence bi-directionally link mitochondria as both targets and drivers of psychosocial experiences. On the one hand, chronic stress exposure and possibly mood states alter multiple aspects of mitochondrial biology; and on the other hand… Show more

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