Psychosocial and medical adversity associated with neonatal neurobehavior in infants born before 30 weeks gestation

Abstract

to the conceptualization and design of the study, and lead the study site teams in protocol implementation and data collection. •Drs. Smith, McGowan, Carter, and Neal contributed to the conceptualization and design of the study, reviewed and revised the manuscript, and led their respective sites' study teams in protocol implementation.• Drs. O' Shea and Lester led the conceptualization and design of the study, critically reviewed and revised the manuscript.• Drs. Helderman, Pastrynak, and Soliman reviewed and revised the manuscript, and led their respective sites' study teams in protocol implementation. •Ms. Dansereau developed the database for this manuscript, implemented the statistical analyses, reviewed and revised the manuscript. •Ms. DellaGrotta worked with the study site teams to execute the protocol, supervised data collection, designed the data collection instruments, reviewed and revised the manuscript.

Analysis of Neonatal Neurobehavior and Developmental Outcomes Among Preterm Infants

“…[10][11][12] NNNS profiles have been previously reported for the Neurobehavioral Outcomes of Very Preterm Infants (NOVI) cohort, and at-risk profiles have been associated with maternal prenatal demographic risk, infant risks of small birth head circumference and sepsis as well as differences in neonatal epigenetic patterns. [13][14][15][16] If neonatal neurobehavioral assessments are early markers of neurologic integrity and function, then identifying high-risk patterns of neurobehavior may allow clinicians to better distinguish, prior to hospital discharge, those at greatest risk for later impairment. The overarching goal and primary NOVI study outcome was to determine associations between neonatal neurobehavior, medical risk, and neurodevelopmental and behavioral outcomes at 2 years.…”

“… 10 , 11 , 12 NNNS profiles have been previously reported for the Neurobehavioral Outcomes of Very Preterm Infants (NOVI) cohort, and at-risk profiles have been associated with maternal prenatal demographic risk, infant risks of small birth head circumference and sepsis as well as differences in neonatal epigenetic patterns. 13 , 14 , 15 , 16 …”

Environmental influences on child health outcomes: cohorts of individuals born very preterm

“…Currently, visits are being completed when NOVI participants are 4.5 and 5 years of age using the ECHO-wide Cohort Protocol. The major findings from NOVI, thus far, relate to associations between infant atypical neurobehavior and specific medical problems such as infant sepsis 9 and brain injury. 10 These infants also displayed unique epigenetic changes 11 and were born to mothers with adverse medical and psychosocial conditions.…”

Prenatal risk factors and neonatal DNA methylation in very preterm infants

“…Adverse prenatal conditions contribute to risk of preterm birth, and may also exacerbate the risk of negative outcomes associated with immaturity and illness in very preterm children [ 11 ]. For example, maternal mood disorders (e.g., depression, anxiety) and medical complications (e.g., pre-eclampsia, pre-pregnancy obesity) during pregnancy predict poorer neurobehavioral outcomes in very preterm neonates [ 11 ], which in turn are associated with longer term impairments [ 12 ]. Sociodemographic risk factors, such as low socioeconomic status, are also associated with poor developmental outcomes for very preterm children [ 13 ].…”