Psychosocial and financial impact of disease among patients of dermatophytosis, a questionnaire-based observational study

Patel, Nayankumar Harshadkumar; Padhiyar, Jignaben Krunal; Patel, Ani; Chhebber, Aseem S; Patel, Bhagirath; Patel, Tejas D

doi:10.4103/idoj.idoj_331_19

Cited by 8 publications

(1 citation statement)

References 11 publications

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“…The impact of dermatophytosis extends beyond the physical symptoms, as it can also have significant social, psychological, and professional implications for affected individuals. As there is currently no vaccination available against dermatophytosis, raising awareness about the condition, facilitating rapid and accurate diagnosis, and implementing effective treatment strategies are crucial to mitigate its spread [24,25].…”

Section: Discussionmentioning

confidence: 99%

Metalloprotease Genes Expression in Trichophyton mentagraphytes and Trichophyton simii Contains Genetic Variations Isolated from Iraqi Patients Resistance to Ketoconazole and Amphotericin B

Hilal Hashoosh,

Al-Aaraji

2024

IOP Conf. Ser.: Earth Environ. Sci.

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This study aimed to use Real-Time Polymerase Chain Reaction analysis, to discover the metalloprotease genes (MEP1-5) in Trichophyton menagraphytes and Trichophyton simii contained Genetic variations and determine their expression and association with the antifungal resistance of dermatophytes. Two species of dermatophytes (five isolates) were used in this study (diagnosed morphologically and molecularly by ITS region previously), which included the following types are (Trichophyton mentagrophytes, and Trichophyton simii) of them contained variations of the percentage of conformity with the gene bank 99% and they were registered with the gene bank. The two species were tested for antifungal susceptibility by using the disk method. RNA was isolated from sample according to the protocol of TRIzol™ Reagent The genes used in this study were the metalloprotease gene (MEP1-5). The Livak method was used for determining gene expression. All the genes were amplified and normalized to 18S-Rrna as reference genes. All Trichophyton simii isolates contains the five genes MEP 1 to 5 but Trichophyton mentagrophytes one isolate contains five genes (MEP1-5) and others isolate contains four gene MEP 1 to 4. It has been found that Amphotericin B inhibits the MEP 4 and MEP 5 genes other than the MEP1,2,3 genes. The MEP2 and3 recorded the highest increase in gene expression after treatmentin in Trichophyton simii, while in Trichophyton mentagrophytes the MEP1 recorded the highest increase in gene expression after treatment fllowed by MEP2,3,4 respectively. It has been found that Amphotericin B, had a better effect to inhibit the genes of fungi of Trichophyton mentagrophytes, and Trichophyton simii other than Ketoconazole, especially the MEP 5 followed by MEP 4.

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Section: Discussionmentioning

confidence: 99%

Metalloprotease Genes Expression in Trichophyton mentagraphytes and Trichophyton simii Contains Genetic Variations Isolated from Iraqi Patients Resistance to Ketoconazole and Amphotericin B

Hilal Hashoosh,

Al-Aaraji

2024

IOP Conf. Ser.: Earth Environ. Sci.

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Dermatophytosis in Rabbits

Coelho,

Morais,

Monteiro

et al. 2024

Veterinary Care of Farm Rabbits

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The economic burden of topical corticosteroid use in dermatophytosis: a cost-of-illness analysis of steroid-modified vs. steroid-naive dermatophytosis

Jagadeesan¹,

Sreekumar

Sajini³

et al. 2023

Clinical and Experimental Dermatology

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Dermatophytosis is one of the leading causes of visits to the Dermatology department, especially in India, where the hot and humid climate favours fungal acquisition and perpetuation. Usual modalities of treatment include the use of either oral or topical antifungals or a combination of both, depending upon the severity and extent of infection as well as the type of causative organism. But lately, steroid-modified dermatophytosis, an iatrogenically perpetuated dermatophytosis caused by the indiscriminate use of topical corticosteroids has emerged as a troublesome pandemic. We planned a cost-of-illness analysis of superficial dermatophytosis assessing the direct costs of dermatophytosis treatment borne by the health system, comparing the direct costs in steroid-naïve and steroid modified dermatophytosis. In our study, the average total cost of treatment for steroid naïve and steroid-modified dermatophytosis was found to be Rs 2172.41 and Rs 3770.60 respectively meaning that the patients who used topical steroids spend additional 40% on an average for treatment, when compared to steroid-naïve patients. The need for more consultations, investigations (considering the atypical presentations) and extended duration of treatment with higher antifungals were found to contribute to the increased financial burden in steroid-modified dermatophytosis.

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Psychosocial and financial impact of disease among patients of dermatophytosis, a questionnaire-based observational study

Cited by 8 publications

References 11 publications

Metalloprotease Genes Expression in Trichophyton mentagraphytes and Trichophyton simii Contains Genetic Variations Isolated from Iraqi Patients Resistance to Ketoconazole and Amphotericin B

Metalloprotease Genes Expression in Trichophyton mentagraphytes and Trichophyton simii Contains Genetic Variations Isolated from Iraqi Patients Resistance to Ketoconazole and Amphotericin B

Dermatophytosis in Rabbits

The economic burden of topical corticosteroid use in dermatophytosis: a cost-of-illness analysis of steroid-modified vs. steroid-naive dermatophytosis

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