Psychosis in neurosyphilis: an association of poor prognosis

Allen, Melissa; Aisenberg, Gabriel M; Nix, Bobby R; Regenold, William T.; Person, Cheryl

doi:10.1016/j.genhosppsych.2014.01.015

Cited by 7 publications

(5 citation statements)

References 4 publications

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“…13 In patients over 60 years, however, remission is less frequent. 14 The elevation of CXCL13 is considered as a biomarker for the disease activity of neurosyphilis. 15 Due to increasing burden of syphilis in Germany especially in large cities such as Cologne, Munich, and Berlin, 5 we recommend a routine serum testing for syphilis in psychiatric patients.…”

Section: Discussionmentioning

confidence: 99%

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Case report—Depression with psychotic features as an atypical presentation of neurosyphilis

Aytulun,

Grannemann,

MacKenzie

et al. 2024

Clinical Case Reports

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Section: Discussionmentioning

confidence: 99%

“…Severely affected individuals are still capable of considerable benefit 13 . In patients over 60 years, however, remission is less frequent 14 . The elevation of CXCL13 is considered as a biomarker for the disease activity of neurosyphilis 15 …”

Section: Discussionmentioning

confidence: 99%

Case report—Depression with psychotic features as an atypical presentation of neurosyphilis

Aytulun,

Grannemann,

MacKenzie

et al. 2024

Clinical Case Reports

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“…In cases in which psychotic symptoms are resistant to treatment, the ongoing use of antipsychotic treatment may be necessary. On follow-up, if a patient demonstrates sustained improvement and no longer displays psychotic symptoms, it is recommended to consider discontinuing antipsychotic treatment to minimize potential adverse effects associated with psychotropic medications [ 2 , 3 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

Neurosyphilis-Induced Folie À Deux: A Case of Prolonged Psychosis

Alves,

Pinheiro Ramos,

Durães

et al. 2023

Cureus

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Neurosyphilis presentations can include psychiatric symptoms such as psychosis, mania, depression, or changes in personality. Therefore, it can lead to a misdiagnosis with psychiatric disorders. The diagnosis is particularly difficult in a subset of patients whose psychotic symptoms are developed as a manifestation of the disease later in life. With the aim to highlight the importance of considering neurosyphilis in the differential diagnosis of late psychosis, it is presented the clinical case of a folie à deux from a Portuguese 69-year-old man, who presented symptoms of psychosis in the emergency room, ultimately diagnosed with neurosyphilis. A selective review of the literature was made using the Pubmed database, with “neurosyphilis”, “psychosis”, “syphilis”, and “folie à deux” as keywords. Patient consent was obtained for the use of clinical data. Neurosyphilis represents the most severe consequence of an untreated syphilis infection and there is a need in the scientific community to establish tools to enhance the precision of diagnosis and treatment.

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“…The benefit of routine syphilis screening for psychiatric patients would be to identify and stage these individuals promptly so that urgent treatment can be initiated. Previous studies have documented psychosis as an ominous symptom of neurosyphilis, and any delay in accurate diagnosis and treatment can result in an increasingly poor outcome (8).…”

Section: Discussionmentioning

confidence: 99%