Psychosis in a multiple sclerosis patient and antipsychotic treatment

Georgopoulou, Ekaterini; Bornivelli, C.; Choustoulakis, Ioannis; Alivanis, Polichronis

doi:10.1186/1744-859x-7-s1-s254

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“…As pointed out above, psychiatric symptoms are commonly shown in MS . So far several studies have reported effects of antipsychotics on psychosis in MS . On the other hand, we verified that the psychosis in our patient with PPMS was refractory to antipsychotics, including risperidone, quetiapine, olanzapine, and asenapine.…”

Section: Discussionsupporting

confidence: 85%

Possible effects of electroconvulsive therapy on refractory psychosis in primary progressive multiple sclerosis: A case report

Narita

Satake

Sato

et al. 2018

Neuropsychopharm Rep

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Section: Discussionsupporting

confidence: 85%

Possible effects of electroconvulsive therapy on refractory psychosis in primary progressive multiple sclerosis: A case report

Narita

Satake

Sato

et al. 2018

Neuropsychopharm Rep

View full text Add to dashboard Cite

show abstract

Psychotic features associated with multiple sclerosis

Kosmidis

Giannakou

Messinis

et al. 2010

International Review of Psychiatry

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Although once considered rare, several more recent investigations have been published describing psychotic features in multiple sclerosis (MS). The association between the two conditions, however, remains unclear. Large-scale hospital-based, epidemiological and case studies have suggested a relationship between psychosis and MS through demonstrating their higher than chance co-occurrence, their temporal relationship, and their association with particular structural abnormalities in the brain (i.e., periventricular white matter and temporal demyelination). The etiology of psychosis in MS has also not been explained adequately. Regional demyelination and the use of corticosteroids have been implicated, yet their mechanisms of action have not been elucidated. The present review addresses what is known at this point in time regarding the occurrence of psychosis in the context of MS, the data regarding possible etiological factors, and the implications of these data and suggestions regarding diagnosis and treatment. Future research should explore the underlying pathophysiology of psychosis and multiple sclerosis to further our understanding of the central nervous system disease process. This research could help determine the features which would guide clinicians in identifying patients at risk of developing psychosis in the context of MS, as well as propose the optimal pharmacological intervention.

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Psychosis in a multiple sclerosis patient and antipsychotic treatment

Cited by 2 publications

References 2 publications

Possible effects of electroconvulsive therapy on refractory psychosis in primary progressive multiple sclerosis: A case report

Possible effects of electroconvulsive therapy on refractory psychosis in primary progressive multiple sclerosis: A case report

Psychotic features associated with multiple sclerosis

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