Psychosis as harbinger of phenytoin toxicity

Borasi, M; Verma, Reena; Gupta, Suraj

doi:10.4103/0971-6580.172272

Cited by 5 publications

(3 citation statements)

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“…Other factors that are associated with the onset of acute psychosis in various case reports include the concentrative or transcendental type of meditation,[ 193 ] COVID-19 vaccine,[ 194 ] drugs like iohexol,[ 175 ] phenytoin,[ 176 177 ] levetiracetam,[ 178 ] disulfiram,[ 179 180 181 ] a combination of baclofen and disulfiram,[ 182 ] armodafinil,[ 183 ] ciprofloxacin,[ 184 ] bupropion,[ 185 ] mephentermine,[ 186 ] antitubercular drugs[ 187 ] like cycloserine,[ 188 189 ] ethambutol,[ 190 ] a combination of interferon alpha2B and ribavarin,[ 191 ] and dapsone. [ 192 ]…”

Section: Resultsmentioning

confidence: 99%

Acute and transient psychotic disorders: A review of Indian research

Grover,

Kathiravan

2023

Indian Journal of Psychiatry

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Background: Acute and transient psychotic disorder (ATPD) was recognized as separate from other psychotic disorders and described in the International Classification of Diseases (ICD) tenth revision for the first time. A lot of research on ATPD has been conducted in India over the last six decades, but a review focusing exclusively on Indian research on ATPD is not available. Aim: This paper aims to review the literature on ATPD emerging from India. Methodology: A combination of search terms “Acute and Transient Psychosis,” “acute psychosis,” “non-affective psychosis,” “non-affective psychotic disorder,” “reactive psychosis,” “first-episode psychosis,” and “India” were searched on various search engines like PUBMED, Medknow, Hinari, and Google Scholar. We also did a hand search for additional relevant articles, including published abstracts of the Indian Journal of Psychiatry from 2007 to 2023. Relevant papers were selected. Results: The prevalence of ATPD varies across different study settings, and it tends to have an abrupt to acute onset, and is primarily associated with stress. Few studies have assessed the subtypes of ATPD, and symptom profile has been inconsistently reported. There is a lack of trials on the effectiveness or efficacy of antipsychotics in ATPD patients. In a large proportion of patients initially diagnosed with ATPD, the diagnosis remains stable, with recurrence varying from 10% to 46.6% based on the duration of follow-up. Conclusion: There is a need for more multicentric studies, studies with larger sample sizes, and consistency in data about risk factors. There is a need to evaluate symptom profile, course, outcome, and treatment outcomes in patients with ATPD using validated instruments to improve our understanding. Further, there is a need for comparative studies to evaluate the risk factors for ATPD.

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Section: Resultsmentioning

confidence: 99%

Acute and transient psychotic disorders: A review of Indian research

Grover,

Kathiravan

2023

Indian Journal of Psychiatry

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“…Gatzonis et al [8] reported the case of acute psychosis developing in a case of trigeminal neuralgia, which improved after stopping phenytoin, although serum levels were again normal. Borasi et al [9] are the only ones who report a chronic epileptic with a history of 15 years of phenytoin intake, presenting with acute psychosis and raised serum levels of the same, who improved after stopping phenytoin. Our case is the only one where a short history of the recommended dosage of phenytoin intake is associated with acute psychosis.…”

Section: Discussionmentioning

confidence: 99%

Phenytoin toxicity manifesting as acute psychosis: An uncommon side effect of a common drug

2019

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“…There is a higher risk of psychosis in patients with epilepsy up to 6-12 times greater than the general population. The literature also shows cases of psychosis following the use of anti-epileptic drugs (AEDs) such as phenytoin and levetiracetam in epileptic patients [ 1 - 2 ]. Not only can each AED cause psychosis, but a mixed-methods study by Chen Z et al, (2016) revealed that the concurrent use of levetiracetam with another AED poses a serious risk of developing an anti-epileptic-induced psychosis in patients with epilepsy [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Phenytoin Augmentation of Levetiracetam Treatment: A Case of Forced Normalization With Emergence of Psychosis

Esang

Kotapati

Ahmed

2018

Cureus

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Forced normalization is the emergence of psychoses following stabilization of seizures in an uncontrolled epileptic patient. The current study is a case of forced normalization, a phenomenon characterized by normalization of electroencephalogram (EEG) findings and resolution of seizures. This case report is unique and rare because the patient meets the diagnostic merit of forced normalization, which occurred due to a nonconventional method of seizure control management. We discuss the recognition and differential diagnoses of such cases, understanding the phenomenon of forced normalization and treatment strategies, which may help clinicians in their clinical practice.

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Psychosis as harbinger of phenytoin toxicity

Cited by 5 publications

References 4 publications

Acute and transient psychotic disorders: A review of Indian research

Acute and transient psychotic disorders: A review of Indian research

Phenytoin toxicity manifesting as acute psychosis: An uncommon side effect of a common drug

Phenytoin Augmentation of Levetiracetam Treatment: A Case of Forced Normalization With Emergence of Psychosis

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