Psychosis and Dandy-Walker syndrome: a case report and review of the literature

Porras-Segovia, Alejandro; Guerrero‐Jiménez, Margarita; Calahorro, C.M. Carrillo de Albornoz; Gutiérrez‐Rojas, Luis

doi:10.1136/gpsych-2020-100254

Cited by 4 publications

(14 citation statements)

References 26 publications

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“…We reviewed clinical and brain imaging data for 18 individuals from 15 reports (Bozkurt Zincir et al, 2014; Buonaguro et al, 2014; Dawra et al, 2017; Ferentinos et al, 2007; Gama, 2019; Gan et al, 2012; Kvitvik Aune & Bugge, 2014; Langarica & Peralta, 2005; Papazisis et al, 2007; Porras Segovia et al, 2021; Rohanachandra et al, 2016; Ryan et al, 2012; Trehout et al, 2019; Turner et al, 2001; Williams et al, 2016). The developmental and psychiatric data were often detailed, describing undifferentiated (unlabeled) psychosis in eight, SCZ in six, and SCZ‐like features in three individuals.…”

Section: Resultsmentioning

confidence: 99%

“…We performed a literature review using pairs of search terms with the first search term either “psychosis” or “schizophrenia,” and the second search term “cerebellar hypoplasia,” “Dandy–Walker malformation” or “Dandy–Walker variant.” Our search yielded 17 papers from 2007 to 2021 describing 20 individuals. Three papers were discarded due to inadequate or no brain imaging, leaving 17 reported individuals plus our proband (Bozkurt Zincir et al, 2014; Buonaguro et al, 2014; Dawra et al, 2017; Ferentinos et al, 2007; Gama, 2019; Gan et al, 2012; Kvitvik Aune & Bugge, 2014; Langarica & Peralta, 2005; Papazisis et al, 2007; Porras Segovia et al, 2021; Rohanachandra et al, 2016; Ryan et al, 2012; Trehout et al, 2019; Turner et al, 2001; Williams et al, 2016).…”

Section: Methodsmentioning

confidence: 99%

“…1a (o) in Trehout (Trehout et al, 2019), and fig. 1 (p) in Porras (Porras Segovia et al, 2021), with permission.…”

Section: Clinical Reportmentioning

confidence: 99%

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Undifferentiated psychosis or schizophrenia associated with vermis‐predominant cerebellar hypoplasia

Leslie,

Ward,

Dobyns

2023

American J of Med Genetics Pt A

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Schizophrenia (SCZ) is a well‐studied neuropsychiatric condition that has been shown to have a high degree of genetic heritability. Still, little data on the specific genetic risk variants associated with the disease exists. Classification of the SCZ phenotype into SCZ‐related endophenotypes is a promising methodology to parse out and elucidate the specific genetic risk variants for each. Here, we present a series of 17 previously reported individuals and a new proband with similar SCZ‐related neuropsychiatric characteristics and shared brain imaging findings. Unsurprisingly, these individuals shared classic psychiatric features of SCZ. Interestingly, we also identified shared neuropsychiatric features in this series of individuals that had not been highlighted previously. A consistently decreased IQ, memory impairment, sleep and speech disturbances, and attention deficits were commonly reported findings. The brain imaging findings among these individuals also consistently showed posterior vermis predominant cerebellar hypoplasia (CBLH‐V). Most individuals' diagnoses were initially described as Dandy–Walker malformation; however, our independent review of imaging suggests a more consistent pattern of posterior vermis predominant cerebellar hypoplasia rather than true Dandy–Walker malformation. While the specific genetic risk variants for this endophenotype are yet to be described, the aim of this paper is to present the shared neuropsychiatric features and consistent, symmetrical brain image findings which suggest that this subset of individuals comprises an endophenotype of SCZ with a high genetic solve rate.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Undifferentiated psychosis or schizophrenia associated with vermis‐predominant cerebellar hypoplasia

Leslie,

Ward,

Dobyns

2023

American J of Med Genetics Pt A

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“…Schizophrenia-like symptoms induced by neurological lesions may present clinical features that differentiate them from primary schizophrenia, which may result in the need for different treatment approaches. [ 13 ] The case may further illuminate the physio-pathology and treatment strategy of psychotic disorders with congenital cerebellum malformation.…”

Section: Introductionmentioning

confidence: 99%

“…Reviewing the literature, the authors have found a few published cases describing co-occurrence of psychotic symptoms and DWS. [2,5,[13][14][15][16] However, few report has described the patient with DWM and hydrocephalus after undergoing surgery. In the present study, we describe a case of a young man who was diagnosed with DWM and seizure co-morbid with suspected atypical schizophrenia-like symptoms.…”

Section: Introductionmentioning

confidence: 99%

Refractory psychiatric symptoms and seizure associated with Dandy-Walker syndrome: A case report and literature review

Chen¹,

Zhu²,

Zhang³

et al. 2022

Medicine

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Backgrounds: Dandy-Walker syndrome (DWS) is a group of brain malformations which occasionally accompanied by psychotic symptoms. The co-occurrence of DWS and epilepsy in children is quite rare. Case description: We reported a 14-year-old male who presented with a 8-month history of inconsistent upper limb tremor and accidental seizure. The MRI showed the typical alterations of DWS: cystic dilatation of the fourth ventricle, vermian hypoplasia, enlarged posterior fossa. He received the ventriculoperitoneal shunting (VPS) placement for hydrocephalus and had a symptom-free period for 8 days. Then he experienced a recurrence of involuntary upper limb tremor and behavior disturbance after decreasing the pressure of cerebrospinal fluid (CSF) from 150 to 130 mm Hg. After being treated with Olanzapine 10 mg/d, Clonazepam 3 mg/qn and Valproate acid (VPA) 500 mg/bid for nearly a month, his mental status and psychotic symptoms fluctuated. A search of Pub Med showed little report of hydrocephalus and DWS comorbidity with seizure and psychosis. Here we presented the whole process of a rare disease from the very beginning with all his symptoms, examinations and treatments. Conclusion: VPS placement surgery at an earlier stage may be an effective way to avoid inevitable brain damage so as to improve the clinical outcomes for patients with DWS. Continued treatment with regard to DWS condition may include shunt placement, but it mainly focus on developmental concerns, with occupational and physical therapy along with ongoing supportive psychotherapy to improve the coping skills and quality of life.

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Tic-Related Obsessive–Compulsive and Eating Disorders in Dandy–Walker Variant: A Case Report and Systematic Reappraisal of Psychiatric Profiles

Bortoletto,

Candolo,

Nicotra

et al. 2024

Brain Sciences

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Dandy–Walker complex (DWC) consists of a continuum of brain malformations involving the posterior fossa, often leading to psychiatric manifestations during adulthood. We discussed the case of a young woman with Dandy–Walker variant (DWV) and a comorbid complex neuropsychiatric presentation, who was diagnosed with an eating disorder, obsessive–compulsive disorder, and a tic disorder. Afterwards, we conducted a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020-compliant systematic review reappraising all evidence of psychiatric outcomes in adults with DWC. Overall, 34 studies were eligible for data extraction, comprising 36 patients. Psychiatric profiles were more common among young adult males, with DWC lesions, especially DWV subtype, being often discovered incidentally after admission to mental health inpatient facilities. Most patients were diagnosed with psychosis and bipolar disorder, often comorbid with cognitive impairment. Psychotropic polypharmacy was frequently prescribed, generally leading to complete recovery. Evidence from our case report and systematic review indicates the importance of monitoring long-term psychiatric sequelae among adult patients with DWC malformations.

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Psychosis and Dandy-Walker syndrome: a case report and review of the literature

Cited by 4 publications

References 26 publications

Undifferentiated psychosis or schizophrenia associated with vermis‐predominant cerebellar hypoplasia

Undifferentiated psychosis or schizophrenia associated with vermis‐predominant cerebellar hypoplasia

Refractory psychiatric symptoms and seizure associated with Dandy-Walker syndrome: A case report and literature review

Tic-Related Obsessive–Compulsive and Eating Disorders in Dandy–Walker Variant: A Case Report and Systematic Reappraisal of Psychiatric Profiles

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