Psychosis and Dandy–Walker complex: report of four cases

Zhang, Gan; Diao, Feiyang; Han, Zili; Li, Kang; Zheng, Lia-rong; Guan, Nianhong; Kang, Zhuang; Wu, Xiaoli; Wei, Qianqian; Cheng, Mingwang; Zhang, Ming; Zhang, Jinbei

doi:10.1016/j.genhosppsych.2011.08.012

Cited by 21 publications

(28 citation statements)

References 12 publications

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“…The varieties of structural abnormality of the brain in these cases might partly contribute to the diversity of the psychiatric symptoms since the position and the severity of the anomalies in the previously mentioned cases were not exactly the same. Despite the wide range of symptoms some common clinical features had been observed in a series of our cases: juvenile or young adult age onset, high frequency of family history of psychosis, atypical psychiatric symptoms, high prevalence of cognitive deficit, borderline intellectual functioning and refractoriness to treatment 15. Most of these features were also found in the cases previously reported 5-9…”

Section: Discussionsupporting

confidence: 44%

“…Considering previous case reports, psychiatric symptoms have been related with DWC but, the spectrum of mental symptoms varies quite widely between cases 15. The varieties of structural abnormality of the brain in these cases might partly contribute to the diversity of the psychiatric symptoms since the position and the severity of the anomalies in the previously mentioned cases were not exactly the same.…”

Section: Discussionmentioning

confidence: 88%

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Schizophrenia-Like Psychosis and Dandy-Walker Variant Comorbidity: Case Report

Zincir

Kıvılcım

İzci

et al. 2014

Psychiatry Investig

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Dandy-Walker variant is a developmental malformation consisting of cerebellar hypoplasia and cystic dilatation of the fourth ventricle. Previous research has proposed a possible role for the cerebellum in cognition and in schizophrenia. In this paper we report a schizophrenia-like psychotic disorder in a 30 year-old woman with Dandy-Walker variant. The patient was treated with risperidone 6 mg/day, biperiden 4 mg/day and risperidone depot 50 mg injections fortnightly, and most of the symptoms were ameliorated within 2 months. The similar cognitive profile to populations with cerebellar pathology and rarity of the condition strongly suggests that there may be direct relationship between cerebellar pathology and appearence of psychotic symptoms.

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Section: Discussionsupporting

confidence: 44%

Section: Discussionmentioning

confidence: 88%

Schizophrenia-Like Psychosis and Dandy-Walker Variant Comorbidity: Case Report

Zincir

Kıvılcım

İzci

et al. 2014

Psychiatry Investig

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“…Other strategies, including antipsychotics and other pharmacological co-treatments are frequently used in clinical practice, despite a lack of evidence of efficacy [73-77]. In our literature review, only two cases highlighted psychotic symptoms treated by clozapine [34, 48] and both revealed a poor outcome. The present patient was treated with clozapine monotherapy and finally showed an improvement of psychotic symptoms, specifically a reduction in total PANSS and BPRS scores of 41.13 and 45.95%, respectively.…”

Section: Discussionmentioning

confidence: 95%

Dandy-Walker Malformation-Like Condition Revealed by Refractory Schizophrenia: A Case Report and Literature Review

et al. 2018

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Introduction: Dandy-Walker malformation is a rare congenital malformation involving cystic dilatation of the fourth ventricle, enlarged posterior fossa, complete or partial agenesis of the cerebellar vermis, elevated tentorium cerebelli, and hydrocephalus. Previous research highlighted a possible role for the cerebellum in schizophrenia as well as the contribution of underlying brain malformations to treatment resistance. Here, we present a case of a Dandy-Walker malformation-like condition revealed by a refractory schizophrenia in a 24-year-old male patient. We also conduct a literature review of all previously published case reports or case series of co-occurring posterior fossa abnormalities and schizophrenia or psychosis using a PubMed search query to better understand the potential link between these two disorders. Case Presentation: A 9-month hospital stay was needed to address the treatment-resistant psychotic symptoms, and the patient continued to experience moderate symptoms despite the prescription of various antipsychotic and antidepressant medications. After an irregular initial medical follow-up, the patient is currently treated with 350 mg daily clozapine and 20 mg daily prazepam and still exhibits moderate anxiety without delirious thoughts, however allowing him to re-enroll at the university. Regarding the literature, 24 cases published between 1996 and 2017 were identified, reviewed and compared to the present case report. Discussion: This case report and literature review further illuminates the pathophysiology of psychotic disorders including the potential role of the cerebellum, reinforces the importance of a multidisciplinary approach for the neurological and psychiatric management of patients with schizophrenia, and highlights optimal pharmacological management strategies for treatment-resistant schizophrenia.

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“…Other psychiatric disorders accompanying this malformation have been rarely reported. In these case reports, generally paranoid delusions and schizophrenia-like psychotic symptoms have been defined in the DWK and DWV cases (11,12,13,14). There are also a few case reports indicating comorbidity of DWS with bipolar disorder (15,16,17,18,19).…”

Section: In 1954mentioning

confidence: 97%