2019
DOI: 10.1111/psyp.13356
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Psychophysiological treatment outcomes: Corticotropin‐releasing factor type 1 receptor antagonist increases inhibition of fear‐potentiated startle in PTSD patients

Abstract: After exposure to a traumatic event, a subset of people develop post‐traumatic stress disorder (PTSD). One of the key deficits in PTSD is regulation of fear, and impaired inhibition of fear‐potentiated startle (FPS) has been identified as a potential physiological biomarker specific to PTSD. As part of a larger clinical trial, this study investigated the effects of a CRF receptor 1 antagonist, GSK561679, on inhibition of fear‐potentiated startle during a conditional discrimination fear‐conditioning paradigm, t… Show more

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Cited by 20 publications
(21 citation statements)
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References 43 publications
(66 reference statements)
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“…The CRHR1 is abundantly expressed in fear-modulating corticolimbic circuits, including the mPFC (Steckler and Holsboer, 1999). Studies in humans and rodents indicate that CRH-CRHR1 hyper-signaling represents a candidate mechanism for PTSD risk (Bremner et al, 1997;Jovanovic et al, 2020;Rajbhandari et al, 2015;Toth et al, 2016). CRHR1 hyper-signaling alters brain structural integrity (Chen et al, 2004;Kolber et al, 2010;Toth et al, 2014) and has long-lasting consequences in stress susceptibility (Uribe-Mariño et al, 2016), mainly when it is triggered early in life (Toth et al, 2016).…”
Section: Age and Diet Modulate The Expression Of The Corticotropin-rementioning
confidence: 99%
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“…The CRHR1 is abundantly expressed in fear-modulating corticolimbic circuits, including the mPFC (Steckler and Holsboer, 1999). Studies in humans and rodents indicate that CRH-CRHR1 hyper-signaling represents a candidate mechanism for PTSD risk (Bremner et al, 1997;Jovanovic et al, 2020;Rajbhandari et al, 2015;Toth et al, 2016). CRHR1 hyper-signaling alters brain structural integrity (Chen et al, 2004;Kolber et al, 2010;Toth et al, 2014) and has long-lasting consequences in stress susceptibility (Uribe-Mariño et al, 2016), mainly when it is triggered early in life (Toth et al, 2016).…”
Section: Age and Diet Modulate The Expression Of The Corticotropin-rementioning
confidence: 99%
“…Second, we reasoned that short-term exposure to an obesogenic diet would reduce the neuronal activation in corticolimbic regions implicated in fear extinction and anxiolytic effects. Finally, given the robust effects of obesogenic diets on the HPA axis and dopamine systems (Boitard et al, 2015;Khazen et al, 2019;Reyes, 2012;Sharma et al, 2013), and the modulatory actions of these factors on mPFC-amygdala circuit function (Fadok et al, 2009b;Jovanovic et al, 2010;2020;Veer et al, 2012;Whittle et al, 2016), we hypothesized that the obesogenic diet would increase the HPA tone while reducing dopamine receptor expression in the mPFC.…”
Section: Introductionmentioning
confidence: 99%
“…There are a wide range of events and contexts that qualify as potentially traumatizing, and within each of these the “dose” of exposure (i.e., magnitude, frequency) has established associations to functional impairment (see, for instance, Neuner et al, 2004; Elbert et al, 2006; Kaltenbach, Schauer, Hermenau, Elbert, & Schalinski, 2018). As such, we selected studies that cover a wide range of trauma exposure types and trauma‐affected populations, from adolescents growing up in conflict zones ( Shaheen et al, ) or experiencing flight and displacement ( Sill, Popov, Schauer, & Elbert, 2019) to adolescent victims of childhood abuse ( Iffland et al, 2019), adult combat‐exposed veterans ( Grupe, Imhoff‐Smoth, Wielgosz, Nitschke, & Davidson, 2019; Macatee et al, 2019), African civil war survivors ( Conrad et al, 2018; Jovanovic et al, ), adults treated for fear and anxiety disorders including PTSD from various types of trauma ( Harricharan et al, 2019; Jovanovic et al, ; Sambuco, Bradley, Herring, Hillbrandt, & Lang, 2019) and childhood abuse ( Lis et al, 2019). Additionally, using a cross‐generational approach, Serpeloni, Nätt, Goncalvez de Assis, Wieling, and Elbert (2019a) studied epigenetic changes associated with domestic and intrafamilial violence in grandmothers, mothers, and adolescents.…”
mentioning
confidence: 99%
“…The selection of articles further reflects the range of measures leveraged in current research on the psychophysiology of trauma exposure. Selected articles demonstrate the utility of fear‐potentiated startle ( Jovanovic et al, 2019; Lis et al, 2019), heart rate ( Grupe et al, 2019; Iffland et al, 2019), and ERPs to decode the translation of trauma exposure into PTSD symptoms ( Macatee et al, 2019; Sill et al, ), together with the power of hemodynamic imaging by means of BOLD responses during emotional scene processing ( Sambuco et al, 2019) or resting‐state connectivity ( Harricharan et al, 2019; Joshi, Duval, Kubat, & Liberzon, 2019).…”
mentioning
confidence: 99%
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