Psychophysiological Predictors of Attentional Dysfunction in Children with Congenital Heart Defects

O'Dougherty, Margaret; Berntson, Gary G.; Boysen, Sarah T.; Wright, Francis S.; Teske, Douglas W.

doi:10.1111/j.1469-8986.1988.tb01247.x

Cited by 18 publications

(8 citation statements)

References 45 publications

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“…4 On the problem behavior scales, parents of CHD children judged them to have more social problems and more attention problems and to display more aggressive behavior than children from the healthy control group. Social problems 5 and defiant behavior 6 as well as a higher risk of attention problems 32 have been reported before in CHD children. Although parents thought their child engaged sufficiently in social activities, they reported problems concerning being teased and not being accepted by peers.…”

Section: Discussionsupporting

confidence: 56%

“…Motor and language difficulties, memory and attention problems, and deficits in executive functioning also appeared in this group. 9,11,14,32 These neuropsychological failings were probably and at least partially responsible for the shortcomings at school level. Although the children in our study group were operated by means of new perfusion techniques, avoiding the use of circulatory arrest and therefore adverse neurodevelopmental outcome, parents still report lower school results and school problems in general.…”

Section: Discussionmentioning

confidence: 99%

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Behavior and Self-Perception in Children with a Surgically Corrected Congenital Heart Disease

Miatton

Wolf²,

François³

et al. 2007

Journal of Developmental &Amp; Behavioral Pediatrics

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Behavior and Self-Perception in Children with a Surgically Corrected Congenital Heart Disease

Miatton

Wolf²,

François³

et al. 2007

Journal of Developmental &Amp; Behavioral Pediatrics

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“…Interestingly, we found a relatively high score on Freedom from Distractibility, a factor which relates to attention and concentration. This favourable finding is in contrast with literature in which specific problem areas in attentional performance for subgroups of children with ConHD have been reported (O'Dougherty, Berntson, Boysen, Wright, & Teske, 1988).…”

Section: Discussioncontrasting

confidence: 99%

Long‐term intellectual functioning and school‐related behavioural outcomes in children and adolescents after invasive treatment for congenital heart disease

Spijkerboer

Utens

Bogers

et al. 2008

British J of Dev Psycho

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In this study, long‐term intellectual functioning and school‐related behavioural outcomes were assessed in a patient sample that underwent invasive treatment for congenital heart disease (ConHD) between 1990 and 1995. The Wechsler Intelligence Scale for Children‐Revised was used to measure intellectual functioning and the Teacher's Report Form to assess teacher‐reported behavioural and emotional problems. Overall, patients had IQ scores that fell within the normal range. The total sample of ConHD children (N = 117, 7–16 years old), however, obtained significantly lower mean scores on Verbal IQ and Verbal Comprehension than reference children. When compared with same‐aged reference peers from the general population, 7–11‐year‐old ConHD children obtained significantly lower mean scores on Total IQ, Verbal IQ, Verbal Comprehension, and Perceptual Organization. In contrast, scores of 12–16‐year‐old ConHD children appeared to be significantly lower on Verbal Comprehension only and significantly higher on Performance IQ. No significant differences were found in intellectual functioning between ConHD boys and girls, nor between different diagnostic groups. The school‐related behavioural and emotional adjustment of this sample of children with treated ConHD was favourable. Overall, this sample of recently treated ConHD children, and especially children aged 7–11 years, showed poorer intellectual functioning in several areas. These findings deserve further attention.

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“…In addition, a higher incidence of behavioral and attention problems have been reported in these patients (8,9). Although the cause of such deficits has not been shown to result from the CPB procedure itself, it is important to identify the potential long-term effects of pediatric cardiac surgery on development.…”

Section: -644 2008)mentioning

confidence: 99%

Plasma Biomarkers in Pediatric Patients Undergoing Cardiopulmonary Bypass

et al. 2008

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ABSTRACT:It is critical to identify at-risk patients and minimize the deleterious effects of cardiopulmonary bypass (CPB) procedures in pediatric populations. The present study screened the plasma proteome of pediatric patients undergoing CPB procedures to identify potential clinical biomarkers related to tissue damage, inflammation, or other pathologies. Blood samples were collected at five different time points from 10 children undergoing a CPB procedure. Plasma was isolated and analyzed using two-dimensional differential in-gel electrophoresis and matrix-assisted laser desorption ionization time of flight mass spectrometry. Levels of differentially regulated proteins identified by two-dimensional differential in-gel electrophoresis, and related proteins were then measured in all time points and patients. As well, associated small molecules and ions were measured. The present study identified 13 proteins and protein isoforms altered in expression, including hemopexin, ceruloplasmin, inter-alpha inhibitor H4, and alpha-2-macroglobulin. Immunoblot analysis revealed significant decreases in each of these proteins during the CPB procedure. Significant changes in the levels of copper, iron, Hb, epinephrine, norepinephrine, and serotonin were observed. The potential markers of pathology (inflammation, oxidative stress) identified during this preliminary study may illuminate opportunities for preventative measures and/or treatments during and following CPB procedures in pediatric patients. (Pediatr Res 63: 638-644, 2008)A lthough cardiopulmonary bypass (CPB) methods are well optimized and mortality rates from pediatric CPB continue to decrease (1,2), surgery-related pathologies are still a major concern. In fact, changes have been observed in levels of cytokines (3), and CD antigens (4) in the blood following CPB procedures. Changes in such molecules may reflect tissue damage, inflammation, and other pathologies that could affect both the long-and short-term patient outcome. These markers of pathology are risk factors for in-hospital or post-discharge morbidity and mortality in pediatric CPB patients (5,6). A more complete catalog of the circulating changes accompanying pediatric CPB surgeries may enable better prevention and treatment of complications.Although survival with good acute outcomes after surgery is increasingly likely with pediatric CPB procedures, neurodevelopmental complications such as lower intelligence, motor deficits, and impaired language skills remain a concern (7). In addition, a higher incidence of behavioral and attention problems have been reported in these patients (8,9). Although the cause of such deficits has not been shown to result from the CPB procedure itself, it is important to identify the potential long-term effects of pediatric cardiac surgery on development.Previous studies by our laboratory have used proteomic techniques-specifically two-dimensional differential in-gel electrophoresis (2-DIGE)-to examine the proteomic profile of various tissues and body fluids (10 -12). We have p...

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Psychophysiological Predictors of Attentional Dysfunction in Children with Congenital Heart Defects

Cited by 18 publications

References 45 publications

Behavior and Self-Perception in Children with a Surgically Corrected Congenital Heart Disease

Behavior and Self-Perception in Children with a Surgically Corrected Congenital Heart Disease

Long‐term intellectual functioning and school‐related behavioural outcomes in children and adolescents after invasive treatment for congenital heart disease

Plasma Biomarkers in Pediatric Patients Undergoing Cardiopulmonary Bypass

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