Psychopharmacological interactions between nicotine and ethanol

Rose, Jed E.; Brauer, Lisa H.; Behm, Frédérique M.; Cramblett, Matthew; Calkins, Kevin; Lawhon, Dawn

doi:10.1080/14622200310001656957

Cited by 161 publications

(151 citation statements)

References 0 publications

Supporting

Mentioning

139

Contrasting

Unclassified

Order By: Relevance

“…In contrast to our results, Rose et al (2004) did not demonstrate any effect of alcohol on the number of cigarettes smoked. It is possible that the inclusion of a 'smoking tab' in the current study helped to elucidate the effect of alcohol on tobacco use by providing an incentive to resist smoking.…”

Section: Discussioncontrasting

confidence: 57%

Modeling the effect of alcohol on smoking lapse behavior

et al. 2006

View full text Add to dashboard Cite

The primary aim of this project was to examine the role of alcohol use in smoking lapse behavior, as alcohol consumption is a known risk factor for poor smoking cessation outcomes. We have developed a novel human laboratory model to examine two primary aspects of alcohol-mediated tobacco relapse: 1) Does alcohol facilitate the initiation of the first cigarette? 2) Once the first cigarette is initiated, does alcohol facilitate subsequent smoking? Using a within-subject design, 16 daily smokers who were also heavy social drinkers received a priming drink (0.03 g/dl or taste masked placebo) and then had the option of initiating a tobacco self-administration session or delaying initiation by five minute increments for up to 50 minutes in exchange for monetary reinforcement. Subsequently, the tobacco self-administration session consisted of a one-hour period, in which subjects could choose to smoke their preferred brand of cigarettes using a smoking topography system or receive monetary reinforcement for cigarettes not smoked. Alcohol craving, tobacco craving, subjective reactivity to alcohol, and nicotine withdrawal were assessed as secondary outcomes. Results demonstrated that after consuming the alcohol beverage, subjects were less able to resist the first cigarette and initiated their smoking sessions sooner, and smoked more cigarettes compared to the placebo beverage. These findings have implications for smoking cessation in alcohol drinkers and model development to assess smoking lapse behavior. Keywordssmoking; lapse behavior; alcohol; craving; human laboratory; monetary reinforcement It is well established that alcohol consumption and tobacco use are highly correlated in both clinical and non-clinical samples. Among alcoholics, 80% to 95% are smokers (DiFranza & Guerrera, 1990;Hughes, 1993;Kalman et al., 2005;Patten et al., 1996;Sobell et al., 1990), as compared to 23% in the general population (CDC, 2003 (DiFranza & Guerrera, 1990;Grant et al., 2004;Hurt et al., 1994) and the severity of alcohol and tobacco dependence is positively correlated (Ellingstad et al., 1999;Gulliver et al., 1995). Smoking is also highly correlated with drinking in nonalcoholic individuals (Carmody et al., 1985;Istvan & Matarazza, 1984), particularly among those who are heavy drinkers. Both laboratory studies and naturalistic observations have demonstrated that alcohol consumption is strongly associated with increased rates of smoking (Glautier et al., 1996;Mitchell et al., 1995;Shiffman et al., 1994). Additionally, there is evidence for cross-substance craving from both clinical and non-clinical samples (Drobes et al., 2000;Tiffany, 1995). Given the high co-occurrence of alcohol and tobacco use, it is not surprising that alcohol has been identified as a risk factor for poor smoking cessation outcomes (Baer & Lichenstein, 1988;Shiffman 1986;Zimmerman et al., 1990). For example, Shiffman (1986) found that 20% of all relapse episodes in smokers involved alcohol consumption. In a real-time examination of first lapse episodes, ...

show abstract

Section: Discussioncontrasting

confidence: 57%

Modeling the effect of alcohol on smoking lapse behavior

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Also, given that alcohol appears to enhance the rewarding effects of nicotine (Glautier et al, 1996;Rose et al, 2002Rose et al, , 2004) and nicotine appears to enhance the rewarding effects of alcohol (Kouri et al, 2004;Perkins et al, 1995), the association between increasing levels of tobacco and alcohol use may reflect bidirectional influences in which the use of one substance makes use of the other substance more rewarding and therefore more likely to progress to greater use. Prior longitudinal research with adolescents and young adults has found that greater alcohol use prospectively predicts greater tobacco use and vice versa (Jackson et al, 2002).…”

Section: Progression To Daily Smoking and Dependencementioning

confidence: 99%

“…Alcohol use can potentiate the rewarding effects of smoking (Glautier et al, 1996;Rose et al, 2002Rose et al, , 2004, which could increase motivation to smoke. Thus, greater levels of alcohol involvement may be associated with a consistent linear increase in the odds of progressing to daily smoking.…”

Section: Introductionmentioning

confidence: 99%

Cigarette smoking and the lifetime alcohol involvement continuum

Kahler

Strong

Papandonatos

et al. 2008

Drug and Alcohol Dependence

View full text Add to dashboard Cite

Greater understanding of how alcohol use relates to the initiation, progression, and persistence of cigarette smoking is of great significance for efforts to prevent and treat smoking and excessive drinking and their substantial combined iatrogenic effects on health. Studies investigating the relationship between levels of alcohol involvement and smoking have typically been limited by analytic approaches that treat drinking behavior and alcohol use disorder diagnoses as separate phenomena rather than as indicators of a single latent alcohol involvement dimension. The purposes of the present study were (a) to create a lifetime index of alcohol involvement that integrates information about alcohol consumption and alcohol problems into a single measure and (b) to relate this index to initiation of smoking, progression from initiation to daily smoking, progression from initiation to dependence, and persistence of smoking. Rasch model analyses of data from 1,508 middle-aged (34-44 years) adults showed that creating an additive index of lifetime alcohol involvement was psychometrically supported. Significant quadratic effects of alcohol involvement on initiation, progression, and persistence of smoking demonstrated that there were specific regions of the alcohol involvement continuum that were particularly strongly related to increased smoking. These results provide the most comprehensive depiction to date of the nature of the relationship between lifetime alcohol involvement and lifetime cigarette smoking and suggest potential avenues for research on the etiology and maintenance of smoking and tobacco dependence.

show abstract

“…It is also possible that when smokers stop, this is part of a broader attempt to reduce their health risks that would include a reduction in alcohol consumption as well 28, 29, 30. A third possibility is that not smoking makes it easier to reduce alcohol consumption or vice versa, because each provides a cue for the other or because of pharmacological interactions between nicotine and alcohol 31, 32.…”

Section: Introductionmentioning

confidence: 99%

Association between smoking and alcohol‐related behaviours: a time–series analysis of population trends in England

et al. 2017

View full text Add to dashboard Cite

AimsThis paper estimates how far monthly changes in prevalence of cigarette smoking, motivation to quit and attempts to stop smoking have been associated with changes in prevalence of high‐risk drinking, and motivation and attempts to reduce alcohol consumption in England.DesignData were used from the Alcohol and Smoking Toolkit Studies between April 2014 and June 2016. These involve monthly household face‐to‐face surveys of representative samples of ~1700 adults in England.MeasurementsAutoregressive Integrated Moving Average with Exogeneous Input (ARIMAX) modelling was used to assess the association over time between monthly prevalence of (a) smoking and high‐risk drinking; (b) high motivation to quit smoking and high motivation to reduce alcohol consumption; and (c) attempts to quit smoking and attempts to reduce alcohol consumption.FindingsMean smoking prevalence over the study period was 18.6% and high‐risk drinking prevalence was 13.0%. A decrease of 1% of the series mean smoking prevalence was associated with a reduction of 0.185% of the mean prevalence of high‐risk drinking 2 months later [95% confidence interval (CI) = 0.033 to 0.337, P = 0.017]. A statistically significant association was not found between prevalence of high motivation to quit smoking and high motivation to reduce alcohol consumption (β = 0.324, 95% CI = –0.371 to 1.019, P = 0.360) or prevalence of attempts to quit smoking and attempts to reduce alcohol consumption (β = −0.026, 95% CI = –1.348 to 1.296, P = 0.969).ConclusionBetween 2014 and 2016, monthly changes in prevalence of smoking in England were associated positively with prevalence of high‐risk drinking. There was no significant association between motivation to stop and motivation to reduce alcohol consumption, or attempts to quit smoking and attempts to reduce alcohol consumption.

show abstract

Psychopharmacological interactions between nicotine and ethanol

Cited by 161 publications

References 0 publications

Modeling the effect of alcohol on smoking lapse behavior

Modeling the effect of alcohol on smoking lapse behavior

Cigarette smoking and the lifetime alcohol involvement continuum

Association between smoking and alcohol‐related behaviours: a time–series analysis of population trends in England

Contact Info

Product

Resources

About