Psychopharmacological Effects of Doxepin Hydrochloride

Ueki, Showa; Ogawa, Norio; Watanabe, Soichi; Gomita, Yutaka; Araki, Yasunori; Fujiwara, Michihiro; YATANI, Atsuko; Koja, Takeshi; Inoue, Masayoshi; Otsuki, Isao; ISHIKO, Jyunichi; SAKAKI, Mariko; SHIMAHARA, Kuniyo; Momiyama, T; MATSUOKA, Chigusa

doi:10.1254/fpj.68.716

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1980

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Effects of psychotropic drugs on ? 9 long-lasting muricide

et al. 1980

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The effects of psychotropic drugs on THC-induced long-lasting muricide were investigated in rats. Changes in open field activity (ambulation and rearing) of the rat were concurrently assessed as an index of behavioral toxicity. Imipramine-like antidepressants, atropine, and antiparkinsonism drugs exhibited a selective inhibitory activity on muricide, whereas the effects of neuroleptics, pentobarbital, diazepam, and methamphetamine were nonspecific. It is also suggested that cholinergic, catecholaminergic, and serotonergic mechanisms are involved in THC-induced muricide. This type of induced muricide appears to be a useful experimental model particularly suitable for the evaluation of antidepressants in correlation with brain amine dynamics.

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