Psychopharmacolgical Acitivities of Ethanol Leaf Extract of Saccharum officinarum

Okokon, Jude; Udoh, Anwanga E; Nyong, Emmanuel E.; Eno, Lekam; Udo, Nsikan

doi:10.26538/tjnpr/v3i2.1

Cited by 7 publications

(6 citation statements)

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“…Biological activities reported on the leaf include antibacterial and anthelmintic (Palaksha et al, 2013), antihyperglycaemic, anti-hyperlipidaemic (Ojewunmi et al, 2013), antioxidant (Ojewunmi et al, 2013;Sun et al, 2014). Diuretic and antiurolithiatic (Palaksha et al, 2015), antidepressant and anticonvulsant (Okokon et al, 2019), analgesic (Okokon et al, 2021) and antimalarial (Okokon et al, 2022) activities.…”

Section: Saccharum Officinarummentioning

confidence: 99%

Antioxidative Stress And Hepatoprotective Activities Of Leaf Extract And Fractions OF Saccharum officinarum in Plasmodium berghei Infected Mice

Okokon

EDEM

Bassey

2022

jcbr

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Saccharum officinarum (Family-Poaceae) is used in Ibibio ethnomedicine for the treatment of various diseases such as malaria. The leaf extract and fractions of S. officinarum were investigated for antioxidative stress and hepatoprotective activities in Plasmodium berghei-infected mice using early infection test model. Antioxidative stress and hepatoprotective potentials were assessed by determining oxidative stress markers levels, liver function indices and histopathology of liver. The leaf extract (170-510 mg/kg, p.o.) exerted significant (p<0.05) antimalarial activity against P. berghei infection in suppressive tests with n-hexane and butanol fractions having the highest activity. The leaf extract and fractions also caused significant (p<0.05) increases in the levels of oxidative stress markers enzymes and molecules (CAT, GPx, GST)with no significant (p>0.05) effect on GSH, SOD and MDA levels in the liver of the treated infected mice. The extract/fractions treatment caused significant (p<0.05) reductions in liver enzymes (ALT, AST and ALP), total and conjugated bilirubin of the treated infected mice. Histology of liver revealed absence or significant reductions in pathological features in the treated infected mice compared to untreated infected mice. These results suggest that the leaf extract/fractions of S. officinarum possess antioxidative stress and hepatoprotective potentials which gives credence to its use in the treatment of malaria.

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Section: Saccharum Officinarummentioning

confidence: 99%

Antioxidative Stress And Hepatoprotective Activities Of Leaf Extract And Fractions OF Saccharum officinarum in Plasmodium berghei Infected Mice

Okokon

EDEM

Bassey

2022

jcbr

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“…Panicum maximum Jacq (Poacace) is a perennial grass which is distributed widely in Africa and other tropical regions of the world (Van Oudtshoorn, 1999) Antidiabetic (Antia et al, 2010), antimalarial and analgesic (Okokon et al, 2012), antibacterial (Gothandam et al, 2010;Doss et al, 2011a;Doss et al, 2011b), antiinflammatory and antipyretic (Okokon et al, 2011), antifungal (Kanife, 2012), anticancer, antioxidative burst and antileishmanial (Okokon et al, 2014) activities of the leaf extract have been reported. Also, Panicum maximum root extract has been reported to possess analgesic and antimalarial…”

Section: Introductionmentioning

confidence: 99%

“…properties (Okokon et al, 2016) with LD50 value of 2738.1 mg/kg, antidepressant and anticonvulsant (Okokon et al, 2018) and anti-inflammatory activities (Udobang et al, 2020) and antiulcerogenic (Okokon et al, 2021). Phytochemical constituents of the root such as alkaloid, flavonoid, tannins, terpenes, saponin, and cardiac glycosides (Okokon et al, 2016) have been reported.…”

Section: Introductionmentioning

confidence: 99%

In vivo inhibitory effect of Panicum maximum root extract on alpha amylase and alpha glucosidase enzymes of rats

Nwakaego

2023

jcbr

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Panicum maximum Jacq, (Poaceae) a medicinal plant used traditionally in the treatment of diseases including diabetes was evaluated for effect on alpha amylase and alpha glucosidase enzymes in vivo. The leaf extract (137, 273, and 547 mg/kg) of Panicum maximum were investigated in vivo for inhibitory effect on alpha amylase and alpha glucosidase enzymes using starch, sucrose and maltose as substrates. Acarbose was used as reference drug. The leaf extract non dose-dependently caused significant (p<0.05) reduction in blood glucose levels of treated rats with the various substrates used. The results suggest that the leaf extract of Panicum maximum have the potentials to inhibit alpha amylase and glucosidase in rats.

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“…SAABMAL, an ethnomedicinal polyherbal formulation containing S. officinarum, is used in Nigeria to treat uncomplicated malaria infection 14 . The reported biological activities of the leaf extracts also include anti-hyperglycaemic, anti-hyperlipidaemic, antioxidant 15 , 16 , antidepressant and anticonvulsant 17 , as well as analgesic 18 activities. Phytochemical investigation of sugarcane juice, and other plant parts, disclosed the presence of long-chain alcohols and acids, glycosides, phytosterols, saponins, tannins, and flavonoids 13 , 19 , 20 .…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo antimalarial activity and chemical profiling of sugarcane leaves

Okokon

Mobley

Edem

et al. 2022

Sci Rep

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Saccharum officinarum Linn. (sugarcane, Family-Poaceae) is employed in Ibibio traditional medicine for the treatment of various infections and diseases such as malaria. We This study aims to assess the antiplasmodial effect of the leaf extract and fractions on human malaria parasite (Plasmodium falciparum) in vitro, and rodent malaria parasite (P. berghei) in vivo, and analyse the bioactive components of the active fraction(s). The leaf extract and fractions of S. officinarum were prepared and their growth inhibitory effects tested against the chloroquine resistant P. falciparum strain (Dd2) and P. berghei infection in mice. An acute toxicity of the extract was determined. A combination of gas chromatography and liquid chromatography-mass spectrometry, and nuclear magnetic resonance spectroscopy was applied for metabolites profiling of crude extract and active fractions. The leaf extract and fractions demonstrated moderate activity against P. falciparum with the dichloromethane fraction producing the most potent activity (EC50 = 15.4 µg/mL). The leaf extract (170–510 mg/kg, p.o., LD50 = 1732 mg/kg) and fractions demonstrated significant (p < 0.05–0.001) effect on P. berghei infection in prophylactic tests as well as in established infection with n-butanol fractions producing the highest effect. An unusual sulphur-containing compound, dilaurylthiodipropionate, fatty acids, phenolic acids, flavonoid and flavonoid glycoside were identified in the active fractions. These results give credence to the use of sugarcane leaves as malarial remedy locally by confirming the in vitro and in vivo antiplasmodial potential of leaf extract/fractions of S. officinarum.

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Psychopharmacolgical Acitivities of Ethanol Leaf Extract of Saccharum officinarum

Cited by 7 publications

References 0 publications

Antioxidative Stress And Hepatoprotective Activities Of Leaf Extract And Fractions OF Saccharum officinarum in Plasmodium berghei Infected Mice

Antioxidative Stress And Hepatoprotective Activities Of Leaf Extract And Fractions OF Saccharum officinarum in Plasmodium berghei Infected Mice

In vivo inhibitory effect of Panicum maximum root extract on alpha amylase and alpha glucosidase enzymes of rats

In vitro and in vivo antimalarial activity and chemical profiling of sugarcane leaves

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