Psychopathology in thalassemia major

Çakaloz, Burcu; Cakaloz, I; Polat, Azız; Inan, Murat; Oğuzhanoğlu, Nalan Kalkan

doi:10.1111/j.1442-200x.2009.02865.x

Cited by 27 publications

(33 citation statements)

References 12 publications

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“…Beta β‐thalassaemia major and its complications carry a significant psychological impact, causing emotional burden, hopelessness and difficulty with social integration, all of which are more prominent in the adolescence period Thalassaemic adolescents in our study have significantly higher psychosocial morbidity with no difference between boys and girls; Saini et al . also made a similar observation…”

Section: Discussionmentioning

confidence: 51%

“…Beta β-thalassaemia major and its complications carry a significant psychological impact, causing emotional burden, hopelessness and difficulty with social integration, all of which are more prominent in the adolescence period 20,53,54 Thalassaemic adolescents in our study have significantly higher psychosocial morbidity with no difference between boys and girls; Saini et al also made a similar observation 55 This morbidity is likely to increase with increasing age-, social-and disease-related factors as is evident from our observation of a positive correlation of PSC mean score with duration of illness, regular blood transfusion and DFO transfusion.…”

Section: Discussionmentioning

confidence: 99%

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Impact of psychosocial status and disease knowledge on deferoxamine adherence among thalassaemia major adolescents

Al-Kloub

Froelicher

2013

Int J of Nursing Practice

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This cross-sectional study aimed to explore the relationship between psychosocial status, disease knowledge and adherence to deferoxamine treatment in adolescents with thalassaemia major. A purposive sample of 36 adolescents with transfusion dependence, ages 12-19 years, was recruited. A semi-structured interview and two structured questionnaires were used. In this sample, 56% were low adherence and 36% were psychologically impaired. Statistically significant factors associated with psychological impairment were: adolescents more than 16 years; low deferoxamine adherence; mean ferritin more than 2500 μg/L; family size more than six; family income equal or less than 350 Jordanian dinar and having sibling with thalassaemia. Additionally, adolescents with high level of knowledge had significantly lower scores on Pediatric Symptom Checklist.

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Impact of psychosocial status and disease knowledge on deferoxamine adherence among thalassaemia major adolescents

Al-Kloub

Froelicher

2013

Int J of Nursing Practice

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“…Literature examining psychological functioning in individuals with thalassemia indicates that this population is vulnerable to experiencing psychological adjustment problems, such as symptoms of depression and anxiety [5–9]. However, except for one study conducted with adult patients in Italy [7], these studies are generally limited to small, homogeneous samples of children [8,9].…”

mentioning

confidence: 99%

Symptoms of depression and anxiety in patients with thalassemia: Prevalence and correlates in the thalassemia longitudinal cohort

et al. 2010

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Thalassemia is an inherited blood disorder that requires lifelong adherence to a complicated and burdensome medical regimen which could potentially impact emotional functioning of patients. The importance of understanding and promoting healthy emotional functioning is crucial not only to psychological well-being, but also to physical health as it has been shown to impact adherence to medical regimens [1–4]. The current study aimed to [1] determine the prevalence of depressive and anxiety symptoms in adolescent and adult patients with thalassemia; and [2] explore possible demographic, medical, and psychosocial correlates of these symptoms in 276 patients (14–58 years old, M age = 27.83; 52% female). Overall, most patients did not report experiencing significant symptoms of anxiety and depression (33% of participants indicated experiencing symptoms of anxiety and 11% symptoms of depression). Females and older patients were more likely to experience these symptoms than males and younger patients. Symptoms of anxiety and depression were positively associated with self-report of difficulty with adherence and negatively associated with quality of life. Given these findings, regular screening for anxiety and depression symptoms could help to identify at-risk individuals to provide them with appropriate psychological support with the goal of improving both emotional and physical health.

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“…A multi center European study reported psychological problems in 47% children (Clemente C et al 2002). In a study of 20 thalassemic and 34 healthy children, it was observed that children with thalassemia were at increased risk of psychopathology (Cakaloz et al 2009). The frequency of psychiatric problems was significantly higher in children with thalassemia (55.0%) as compared to the control group (14.7%).…”

Section: Discussionmentioning

confidence: 96%

Psychopathology in Children with Thalassemia Major

et al. 2011

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The present work investigated the prevalence and spectrum of psychopathology in children with thalassemia. Childhood psychopathology measurement schedule (CPMS), adapted from Child Behavior Checklist was administered on children with thalassemia major receiving regular blood transfusion. Age and sex matched children with other chronic illness (bronchial asthma) served as controls. 46.7% of children with thalassemia had a CPMS score of > 10 as against 17.1% in the control group. Children with thalassemia had higher scores in factors of conduct problems, special symptoms and somatization. This study highlights the significantly higher psychopathology in children with thalassemia major and emphasizes the need for psychosocial support during treatment.

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Psychopathology in thalassemia major

Abstract: Children with TM are posed with an increased risk of psychopathology.

Cited by 27 publications

References 12 publications

Impact of psychosocial status and disease knowledge on deferoxamine adherence among thalassaemia major adolescents

Impact of psychosocial status and disease knowledge on deferoxamine adherence among thalassaemia major adolescents

Symptoms of depression and anxiety in patients with thalassemia: Prevalence and correlates in the thalassemia longitudinal cohort

Psychopathology in Children with Thalassemia Major

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