Psychopathology in Sickle Cell Disease

Alao, Adekola O.; Mj, Dewan; Jindal, Shefali; Effron, Mark B.

doi:10.4314/wajm.v22i4.28059

Cited by 9 publications

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“…The results are however dissimilar to psychosocial findings among United Kingdom and United States of America SCD participants where high incidence and prevalence of psychological symptoms are reported among participants with SCD [10, 12, 13, 33, 34]. Levenson and colleagues [10] found a high prevalence of about 28 % of depression among African Americans.…”

Section: Discussionmentioning

confidence: 56%

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Prevalence of psychological symptoms among adults with sickle cell disease in Korle-Bu Teaching Hospital, Ghana

2016

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BackgroundPrevious research revealed high prevalence of psychological symptoms among sickle cell disease (SCD) patients in the West and Europe. In some Black SCD populations such as Nigeria and Jamaica, anxiety and depression had low prevalence rates compared to Europe. With difficulty locating research data on the prevalence of psychological symptoms in Ghana, this study aimed at exploring psychological symptoms among adults with SCD in a Teaching Hospital in Accra, Ghana.MethodsTwo hundred and one participants (males 102 and females 99) who were HbSS (n = 131) and HbSC (n = 70), aged 18 years and above were purposively recruited. Using the Brief Symptom Inventory (BSI) in a cross-sectional survey, the research answered questions about the prevalence of psychological symptoms. It also examined gender and genotype differences in psychological symptoms scores.ResultsResults indicated that adults with SCD had non-distress psychological symptoms scores. Although paranoid ideation as a psychological symptom indicated “a little bit” score, its prevalence was only 1 %. The prevalence of psychological symptoms as indexed by the Positive Symptom Total (PST) was 10 %. Anxiety, hostility, and depression were psychological symptoms with low scores. Furthermore, except psychoticism scores, males did not differ significantly from females in other psychological symptoms. On the contrary, HbSS participants differed significantly, reporting more psychological symptoms than their HbSC counterparts.ConclusionsThe study concluded that there was low prevalence of psychological symptoms among adults with SCD in this Ghanaian study. Although psychological symptoms distress scores were not observed among study participants at this time, females differed significantly by experiencing more psychoticism symptoms than males. HbSS participants also differed significantly by experiencing more depression, phobic anxiety, paranoid ideation, psychoticism, and additional symptoms such as poor appetite, trouble falling asleep, thoughts of dying, and feeling guilty, than their HbSC counterparts. Implications for further study and clinical practice were discussed.

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Section: Discussionmentioning

confidence: 56%

“…Psychological symptoms have been reported in western literature to be highly prevalent among adults with sickle cell disease [10–13]. Depression rates, for example, are comparable to those found in other serious chronic medical diseases.…”

Section: Introductionmentioning

confidence: 98%

Prevalence of psychological symptoms among adults with sickle cell disease in Korle-Bu Teaching Hospital, Ghana

2016

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“…1,4,6 As psychologic, behavioral, and cultural profiles influence the perception of patients with pain, and thus their ability to cope with it, 7 long-term illness significantly impacts coping skills and increases the risk of depression, helplessness, and negative health outcomes. 8 In this regard, psychologic comorbidities were associated with SCA [9][10][11][12] particularly in patients with frequent painful VOC, 13 highlighted by increased depression rates among SCA patients according to some, 14,15 but not all 16 studies. Presence of VOC affects daily activities of pediatric and adult SCA patients, resulting in ineffective pain-coping strategies, poor quality of life resulting from decreased participation in daily activities, social isolation, and lack of emotional well-being, thus, resulting in increased anxiety and depression.…”

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confidence: 99%

Depression, Anxiety, and Stress Comorbidities in Sickle Cell Anemia Patients With Vaso-occlusive Crisis

Mahdi¹,

Al-Ola

Khalek

et al. 2010

Journal of Pediatric Hematology/Oncology

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We investigated the association of sickle cell anemia (SCA) vaso-occlusive crisis (VOC) with depression, anxiety, and stress disorders among Bahraini patients and controls. This was a cross-sectional study that involved administering Depression Anxiety Stress Scales (DASS-21) consisting of structured depression, anxiety, and stress scales to SCA patients with (n=138) and without (n=105) VOC. Multinomial regression and correlation analysis were used in assessing the association of VOC with depression and/or anxiety and/or stress, after adjusting for other covariates. Significantly higher proportion of VOC patients was found among the severe-extremely severe anxiety (P<0.002) and stress (P=0.001) groups; the frequency of depressed patients was comparable between the 2 groups. Adjusting for age, sex, income, number of affected individuals per family, and HbS levels, mild-moderate (P=0.042; odds ratio=2.00; 95% confidence interval=1.03-3.91) and severe-extremely severe (P=0.004; odds ratio=4.43; 95% confidence interval=1.59-12.34) anxiety were independently associated with VOC. Both depression and stress were not associated with VOC after adjusting for these covariates. These results suggest a positive contribution of VOC to the increased rates of anxiety disorders among SCA patients, thereby recommending counseling SCA patients with repeated VOC for these psychologic comorbidities, in particular anxiety.

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“…Reflexo indireto do histórico de faltas por internações, o fraco desempenho escolar que muitos possuem favorece a repetência e dificulta o progresso acadêmico. O menor contato entre colegas é, em algum grau, uma realidade fatídi-ca 2,6,9,10 . Não é incomum nessa faixa etária que os sinais físicos da anemia falciforme motivem a exclusão do portador dos círculos de amizade, muitas vezes, com a errônea justificativa de que possui uma enfermidade contagiosa 11 .…”

Section: Introductionunclassified

“…Em adultos com anemia falciforme, taxas de depressão variam de 18% a 44%, valores similares aos encontrados para outras condições crônicas severas 9 . Por sua vez, a depressão contribui de forma negativa no prognóstico da anemia falciforme 10 . Os sintomas depressivos são capazes de reduzir o limiar de tolerância para dor e a capacidade individual de lidar com essa experiência desagradá-vel.…”

Section: Introductionunclassified

Sintomas depressivos em crianças e adolescentes com anemia falciforme

Barreto

Cipolotti²

2011

J. bras. psiquiatr.

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rESUMo objetivo: Determinar a frequência de sintomas depressivos em crianças e adolescentes com anemia falciforme, bem como caracterizar e associar tal sintomatologia aos dados individuais. Métodos: Realizou-se um estudo transversal com portadores de anemia falciforme dos 7 aos 17 anos, atendidos em um ambulatório de Hematologia Pediátrica, os quais preencheram o Inventário de Depressão Infantil (CDI). resultados: Foram avaliados 76 pacientes, estabelecendo-se em 13 o ponto de corte. Vinte e seis pacientes (34,2%) apresentavam sintomas sugestivos de depressão. "Não ser tão bom quanto os outros colegas" foi o item mais pontuado, além de ter predominado significativamente naqueles com escore de CDI maior ou igual a 13, assim como as variáveis: ter pais separados ou viúvos e renda familiar mensal menor ou igual a R$ 510,00. O item "preocupação com dores" foi bem pontuado, independentemente da presença de sintomas depressivos (p = 0,1). Conclusão: A depressão em crianças e adolescentes com anemia falciforme ainda é pouco estudada. Os dados obtidos indicam frequência elevada de sintomas depressivos nessa população. Possivelmente, conviver precocemente com a separação dos pais e pertencer a uma família com baixa renda esteja relacionado ao desenvolvimento desses sintomas.

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Psychopathology in Sickle Cell Disease

Cited by 9 publications

References 0 publications

Prevalence of psychological symptoms among adults with sickle cell disease in Korle-Bu Teaching Hospital, Ghana

Prevalence of psychological symptoms among adults with sickle cell disease in Korle-Bu Teaching Hospital, Ghana

Depression, Anxiety, and Stress Comorbidities in Sickle Cell Anemia Patients With Vaso-occlusive Crisis

Sintomas depressivos em crianças e adolescentes com anemia falciforme

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