Psychopathology in patients with sickle cell disease

Leavell, Sandra R.; Ford, Charles V.

doi:10.1016/s0033-3182(83)73256-1

Cited by 32 publications

(22 citation statements)

References 6 publications

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“…7,8 Depression was found to be associated with frequent hospitalization for vaso-occlusive pain, more emergency room visits, and recurrent blood transfusion. 9 Moreover, depression is associated with clinical complications, 10 and in a study by Nadel and Portadin, 11 50% of patients heralded depressive symptoms heralded painful episodes.…”

Section: Introductionmentioning

confidence: 99%

Depression, quality of life, and medical resource utilization in sickle cell disease

et al. 2017

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Key Points• Depression was found in 35.2% of adult SCD patients and was strongly associated with worse physical and mental quality-of-life outcomes.• Total health care costs for adult SCD patients with depression were more than double those of SCD patients without depression.Sickle cell disease (SCD) is a chronic, debilitating disorder. Chronically ill patients are at risk for depression, which can affect health-related quality of life (HRQoL), health care utilization, and cost. We performed an analytic epidemiologic prospective study to determine the prevalence of depression in adult patients with SCD and its association with HRQoL and medical resource utilization. Depression was measured by the Beck Depression Inventory and clinical history in adult SCD outpatients at a comprehensive SCD center. HRQoL was assessed using the SF36 form, and data were collected on medical resource utilization and corresponding cost. Neurocognitive functions were assessed using the CNS Vital Signs tool.Pain diaries were used to record daily pain. Out of 142 enrolled patients, 42 (35.2%) had depression. Depression was associated with worse physical and mental HRQoL scores (P , .0001 and P , .0001, respectively). Mean total inpatient costs ($25 000 vs $7487, P 5 .02) and total health care costs ($30 665 vs $13 016, P 5 .01) were significantly higher in patients with depression during the 12 months preceding diagnosis. Similarly, during the 6 months following diagnosis, mean total health care costs were significantly higher in depressed patients than in nondepressed patients ($13 766 vs $8670, P 5 .04). Depression is prevalent in adult patients with SCD and is associated with worse HRQoL and higher total health care costs. Efforts should focus on prevention, early diagnosis, and therapy for depression in SCD.

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Section: Introductionmentioning

confidence: 99%

Depression, quality of life, and medical resource utilization in sickle cell disease

et al. 2017

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“…No relationship was seen between psychological problems and illness severity; SCD patients had fewer social relationships than did controls Leavell & Ford 11 SRE, STAI, structured 16 adults with SCD Males had more psychological Social psychotherapy should interviews, self-report problems and medical be provided to increase complications than did social support; close doctorfemales; no specific patient relationships are psychological patterns were helpful found to be characteristic of SCD patients. More life stresses and changes were correlated with increasesand more social support, with decreases-in SCD symptoms Lee et al 33 DSRS, PCS 14 children with SCD, The healthy siblings had Treatment should include 14 healthy siblings higher depression scores family psychoeducation than did the patients ( p ϭ 0.004).…”

Section: Sickle Cell Diseasementioning

confidence: 92%

“…15 Increased life stresses may worsen complications of SCD and increase the risk of depressive symptoms. 11 Persons with the disorder may experience financial difficulties, impoverishment, employment troubles, social ridicule, frequent hospitalizations, poor decision-making and coping strategies, problems with daily activities, and difficulties in coping with the illness. 23,28 Psychological manifestations include depression, as well as generalized anxiety, anxiety about one's body, fear of invasive treatments, preoccupation with death, self-pity, and low self-esteem.…”

Section: Scd and Depression In Children And Adolescentsmentioning

confidence: 99%

Depression and Sickle Cell Disease

Alao¹,

Cooley²

2001

Harv Rev Psychiatry

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Depressive symptoms are very common in patients with a chronic medical illness such as sickle cell disease (SCD). Clinicians may fail to recognize depression in such patients when, as in SCD, the two conditions have many overlapping symptoms. Based on a Medline database search, we review papers addressing the relationship between depression and SCD. Data regarding this relationship are conflicting. We provide recommendations for improving the treatment of patients with SCD and depression.

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“…Frequent painful and hemolytic crises requiring hospitalization often occur several times a year (Belgrave & Molock, 1991;Nadel & Portadin, 1977). There is social disability and psychiatric morbidity (Leavell & Ford, 1983;Whitten & Fischhoff, 1974). They have remarkable physical characteristics (Brozovic & Davies, 1987) and often leave their parents financially and emotionally exhausted (Burlew, Evans, & Oler, 1989).…”

Section: Sickle Cell Disease and Ogbanjementioning

confidence: 99%

Ogbanje/abikuand cultural conceptualizations of psychopathology in Nigeria

Ilechukwu

2007

Mental Health, Religion & Culture

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Ogbanje/abiku refer to people who are believed to cycle rapidly and repeatedly through birth and death. A consecutive familial sequence of births and deaths of infants is construed as the same child dying and being born over and over again. The Igbos believe that ogbanje results from subversion of human destiny by willful alliance of the newborn with deities who guard the postulated interface between birth and pre-birth (spirit) existence, while the Yoruba attribute many abiku to possession of a pregnancy by spirit pranksters most often referred to as emere. Surviving persons manifest abnormalities of psychological life with vivid fantasy life or dreams characterized by the presence of water, orgiastic play with unfamiliar children, and frightening contact with a water goddess-mammy water. Labeled children and adolescents often exhibit manipulative, histrionic dissociative, and other maladaptive behavior. They may also be gifted. Contradictory and facultative practices of excessive indulgence of and ostentatious hostility towards ogbanje/abiku children are described but are better understood as exhibitions of acceptance of life and rejection of death. This paper reports one study of the deployment of cultural cosmology in shaping individual and group adaptive responses to high infant mortality in Nigeria.

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Psychopathology in patients with sickle cell disease

Cited by 32 publications

References 6 publications

Depression, quality of life, and medical resource utilization in sickle cell disease

Depression, quality of life, and medical resource utilization in sickle cell disease

Depression and Sickle Cell Disease

Ogbanje/abikuand cultural conceptualizations of psychopathology in Nigeria

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