Psychopathology in offspring from multiplex alcohol dependence families with and without parental alcohol dependence: A prospective study during childhood and adolescence

Abstract

Multiplex families ascertained through multiple alcohol dependent individuals appear to transmit alcohol and drug use disorders at higher rates than randomly selected families of alcoholics. Our goal was to investigate the risk of developing specific psychiatric diagnoses during childhood or adolescence in association with familial risk status (high-risk [HR] or low-risk [LR]) and parental diagnosis. Using a prospective longitudinal design, HR offspring from three generation multiplex alcohol dependence families and LR control families were followed yearly. Data analysis was based on consensus diagnoses from 1738 yearly evaluations conducted with the offspring and a parent using the K-SADS, and separately modeled the effects of familial susceptibility and exposure to parental alcohol dependence. Multiplex family membership and parental alcohol and drug dependence significantly increased the odds that offspring would experience some form of psychopathology during childhood or adolescence, particularly externalizing disorders. Additionally, parental alcohol dependence increased the odds that adolescent offspring would have major depressive disorder (MDD). While it is well known that parental substance dependence is associated with externalizing psychopathology, the increased risk for MDD seen during adolescence in the present study suggests the need for greater vigilance of these children.

Struggling with one’s own parenting after an upbringing with substance abusing parents

“…Growing up with substance abusing parents influences the child in many ways and studies have found links between parental substance abuse and the development of anxiety and affective disorders both in children (Hill et al, 2008) and in young people (Chen, Subramanian, Acevedo-Garcia, & Kawachi, 2005; Hill et al, 2008; Kelley, Pearson, Trinh, Klostermann, & Krakowski, 2011) as well as an increased risk of developing substance abuse (Buu et al, 2009; Johnson & Leff, 1999; Kendler, Ohlsson, Sundquist, & Sundquist, 2015; Yule, Wilens, Martelon, Simon, & Biederman, 2013). …”

Cross-Generational Effects of Alcohol Dependence in Humans on HRAS and TP53 Methylation in Offspring

“…Participants were from pedigrees acquired through ongoing family studies in which two types of families were recruited, those with a high density of alcohol dependence cases (High-Risk) and those with minimal alcohol dependence within the extended pedigree, as previously described [26]. Third generation members of these families were seen multiple times as part of a longitudinal follow-up that extended from childhood to young-adulthood.…”

Trabajar con hijos de familias drogodependientes: la intervención de grupo TRAMPOLINE radicada en la comunidad

“…Como demuestra un gran número de estudios, los HA presentan un elevado riesgo de desarrollar problemas psicológicos de relevancia psiquiátrica en la adolescencia o la vida adulta. Los hijos de familias afectadas por toxicodependencias presentan una elevada apariencia de exteriorizar los problemas, en forma de trastornos de conducta (Hill et al, 2008;Molina, Donovan y Belendiuk, 2010;Waldron, Martin y Heath, 2009) o trastornos hipercinéticos (Marmorstein, Iacono y McGue, 2009;Molina et al, 2010). También exhiben más problemas de interiorización que sus compañeros, tales como un porcentaje más elevado de depresión o ansiedad (Hill, Tessner y McDermott, 2011;Kelley, Pearson, Trinh, Klostermann y Krakowski, 2011;Klein et al, 2003).…”

“…As a multitude of studies demonstrate, COA's show an elevated risk of developing mental problems of psychiatric relevance in adolescence or adulthood. Children from substance-affected families show an increased appearance of externalizing problems, such as conduct disorders (Hill et al, 2008;Molina, Donovan, & Belendiuk, 2010;Waldron, Martin, & Heath, 2009) or hyperkinetic disorders (Marmorstein, Iacono, & McGue, 2009;Molina et al, 2010). They also exhibit more internalizing problems than their peers such as a higher percentage of depression or anxiety (Hill, Tessner, & McDermott, 2011;Kelley, Pearson, Trinh, Klostermann, & Krakowski, 2011;Klein et al, 2003).…”