Psychopathology and social functioning of 42 subjects from a Danish ultra high‐risk cohort

Madsen, Helle Karkov; Nordholm, Dorte; Krakauer, Kristine; Randers, Lasse; Nordentoft, Merete

doi:10.1111/eip.12438

Cited by 10 publications

(11 citation statements)

References 42 publications

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“…Data on psychopathology, social functioning , premorbid adjustment , systemic oxidative DNA, and RNA damage in part of the UHR cohort have previously been published.…”

Section: Resultsmentioning

confidence: 99%

White matter maturation during 12 months in individuals at ultra‐high‐risk for psychosis

Krakauer

Nordentoft

Glenthøj

et al. 2017

Acta Psychiatr Scand

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“…Data on psychopathology, social functioning , premorbid adjustment , systemic oxidative DNA, and RNA damage in part of the UHR cohort have previously been published.…”

Section: Resultsmentioning

confidence: 99%

White matter maturation during 12 months in individuals at ultra‐high‐risk for psychosis

Krakauer

Nordentoft

Glenthøj

et al. 2017

Acta Psychiatr Scand

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“…Madsen et al [ 13 ] investigated comorbidities, psychosocial difficulties and gender differences in a sample of 42 CHR in order to identify the needs of this population and to improve current treatment options. The sample was assessed with the CAARMS [ 8 ] and other psychiatric scales.…”

Section: Resultsmentioning

confidence: 99%

“…As regards the association between social anxiety disorder and social functioning, in Madsen et al [ 13 ], CHR adolescents and young adults had a low social functioning, codified as “severe impairment”. However, the absence of a control group and the small sample of CHR subjects included narrow the validity of this finding.…”

Section: Discussionmentioning

confidence: 99%

An Overview of Recent Findings on Social Anxiety Disorder in Adolescents and Young Adults at Clinical High Risk for Psychosis

et al. 2017

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Background: Some studies have shown that anxiety is particularly frequent in the Clinical High Risk (CHR) for psychosis population. Notably, social anxiety disorder is identified as one of the most common anxiety disorders in CHR adolescents and young adults. Despite this, the frequency and the clinical significance of social anxiety in this population have been underestimated. Methods: A selective review of literature published between 2011 and 2017 on social anxiety disorder in CHR adolescents and young adults. Results: Five studies are included. In particular, three studies demonstrated that CHR adolescents and young adults have higher levels of anxiety compared to controls. Furthermore, anxiety, including social anxiety, is related to the severity of psychotic symptoms. The other studies included show inconsistent results regarding the possible relationship between social anxiety and social functioning. Conclusions: To date, the eidence concerning the comorbidity of social anxiety disorder and CHR in adolescents and young adults is not sufficient to provide clear guidelines for clinical practice. Future longitudinal studies on larger samples of the CHR adolescents and young adults are required to examine the relationship between social anxiety disorder and the presence of attenuated psychotic symptomatology.

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“…This cascade could emerge early in the disease trajectory, before manifestation of frank psychosis. Indeed, CHR patients exhibit similar social, academic and occupational functional deficits to patients with psychosis (Addington & Heinssen, 2012; Addington, Penn, Woods, Addington, & Perkins, 2008; Ballon, Kaur, Marks, & Cadenhead, 2007; Cornblatt et al, 2007; Fusar‐Poli et al, 2010; Madsen, Nordholm, Krakauer, Randers, & Nordentoft, 2018). Thus, we hypothesized that in CHR patients, severity of N400 priming deficits would be correlated with functional impairment.…”

Section: Introductionmentioning

confidence: 99%

N400 event‐related brain potential as an index of real‐world and neurocognitive function in patients at clinical high risk for schizophrenia

Lepock

Ahmed

Mizrahi

et al. 2019

Early Intervention Psych

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Aim The N400 event‐related potential is a neurophysiological index of cognitive processing of real‐world knowledge. In healthy populations, N400 amplitude is smaller in response to stimuli that are more related to preceding context. This ‘N400 semantic priming effect’ is thought to reflect activation of contextually related information in semantic memory (SM). N400 semantic priming deficits have been found in schizophrenia, and in patients at clinical high risk (CHR) for this disorder. Because this abnormality in processing relationships between meaningful stimuli could affect ability to navigate everyday situations, we hypothesized it would be associated with real‐world functional impairment in CHR patients. Second, we hypothesized it would correlate with global neurocognitive impairment in this group. Methods We measured N400 semantic priming in 35 CHR patients who viewed prime words each followed by a related or unrelated target word, at stimulus‐onset asynchrony (SOA) of 300 or 750 ms. We measured academic/occupational and social function with the global function (GF): Role and Social scales, and cognitive function with the MATRICS Consensus Cognitive Battery (MCCB). Results Decreased N400 semantic priming at the 300‐ms SOA correlated with lower GF:Role scores. Decreased N400 semantic priming at the 750‐ms SOA correlated with lower MCCB composite scores. Conclusions Deficits in activating contextually related concepts in SM over short time intervals may contribute to functional impairment in CHR patients. Furthermore, N400 priming deficits over longer intervals may be a biomarker of global cognitive dysfunction in this population. Longitudinal studies are needed to determine whether these deficits are associated with schizophrenia risk within this population.

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Psychopathology and social functioning of 42 subjects from a Danish ultra high‐risk cohort

Cited by 10 publications

References 42 publications

White matter maturation during 12 months in individuals at ultra‐high‐risk for psychosis

White matter maturation during 12 months in individuals at ultra‐high‐risk for psychosis

An Overview of Recent Findings on Social Anxiety Disorder in Adolescents and Young Adults at Clinical High Risk for Psychosis

N400 event‐related brain potential as an index of real‐world and neurocognitive function in patients at clinical high risk for schizophrenia

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