Psychopathology and Social Functioning in Women with Turner Syndrome

Downey, Jennifer I.; Ehrhardt, Anke Α.; Gruen, Rhoda; Bell, Jennifer J.; Morishima, Akira

doi:10.1097/00005053-198904000-00002

Cited by 87 publications

(75 citation statements)

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“…The small sample size and the absence of a structured diagnostic interview may account for the discrepant findings of this study. In contrast, Downey et al administered a structured diagnostic interview to 23 women with TS drawn from their private practice and reported a 70% lifetime prevalence of psychiatric illness 23 . However, the higher rate of lifetime psychiatric illness observed by Downey et al may reflect the selection of women with more severe mood and behavioral symptoms present in this practice.…”

Section: Discussionmentioning

confidence: 99%

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Current and lifetime psychiatric illness in women with Turner syndrome

Cardoso

Daly

Haq

et al. 2004

Gynecological Endocrinology

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Abnormalities in quality of life and cognitive measures have been observed in women with Turner syndrome (TS), and a relationship between these phenomena and chromosomal constitution has been suggested. In contrast, few studies have systematically evaluated the presence of mood and behavioral syndromes in these women. In this study, 100 TS women were administered the Structured Clinical Interview for DSM IV after a two-week period during which their hormone replacement had been discontinued. The majority of women who met criteria for a psychiatric condition had a mood or anxiety disorder. Overall, 52 (52%) of the TS women met criteria for a current or a past depressive or anxiety disorder. Eighteen of the women with TS met criteria for a current Axis I psychiatric disorder [Depression -major (n = 5), minor (n = 5), dysthymia (n = 1); Anxiety (n = 9)]. Forty-six of the women with TS met criteria for a past Axis I psychiatric illness [Depression: unipolar (n = 41), bipolar (n = 3); Anxiety (n = 7); eating disorder (n = 6); substance dependence (n = 3)]. Five women with TS met criteria for an Axis II personality disorder. Women with TS reported a higher rate of lifetime depression compared with rates observed in community-based studies but similar to those obtained from gynecologic clinic samples.

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Section: Discussionmentioning

confidence: 99%

“…Whether these psychological features observed in girls with TS portend an increased risk of psychiatric diagnoses in adult life is unclear. The few prior studies 16,22,23 showed a broad range of lifetime prevalences of psychiatric disorders in TS women.…”

Section: Introductionmentioning

confidence: 99%

Current and lifetime psychiatric illness in women with Turner syndrome

Cardoso

Daly

Haq

et al. 2004

Gynecological Endocrinology

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“…Women suffering from estrogen deficiencies due to partial or complete loss of the second X-chromosome in Turner Syndrome (TS) express high rates of lifetime psychopathology (~69%) and current depression (~17%) (Downey et al, 1989).…”

Section: Estrogen Deficiencymentioning

confidence: 99%

Assessing gonadal hormone contributions to affective psychopathologies across humans and animal models

Mueller

Grissom

Dohanich

2014

Psychoneuroendocrinology

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Despite increasing acknowledgement of hormonal contributions to mood and anxiety disorders, the underlying mechanisms by which gonadal hormones influence psychopathology-related behaviours remain unknown. This review focuses on recent research that examines the influence of gonadal steroid hormones, including androgens, estrogens, and progesterone, on mood and anxiety-related behaviours in human health and disease. To this aim, the literature was surveyed for studies that assess conditions with suspected underlying hormonal imbalances in otherwise healthy participants (e.g., Premenstrual Dysphoric Disorder, Postmenopausal Depression,) as well as conditions linked to congenital endocrine abormalities (e.g., Turner Syndrome, Klinefelter Syndrome, Polycystic Ovary Syndrome, Congenital Adrenal Hyperplasia, Familial Male Precocious Puberty, Androgen Insensitivity Syndrome). Furthermore, to better inform clinical work and to create a translational bridge, a second goal was to set human psychopathologies and animal models of these conditions side-by-side. In the second part of the review, based on consistencies revealed in the existing literature across conditions, a new model for the impact of gonadal hormones on anxious and depressed behavioural states is proposed. Finally, we conclude by proposing directions for future research, including the development of specific tasks suitable for cross-species comparisons to increase our knowledge of the role of gonadal hormones in mood and anxiety.

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“…Em comparação com a população como um todo, mulheres com ST relatam ter suas primeiras experiências sexuais com mais idade, são sexualmente menos ativas e casam-se menos 6,18,19,[22][23][24][25][26][27] .…”

Section: J Pediatr (Rio Junclassified