Psychopathology and lymphocyte subsets in patients with bulimia nervosa

Vaz-Leal, Francisco J.; Rodríguez-Santos, Laura; Melero-Ruiz, M. Josefa; Ramos-Fuentes, María Isabel; García-Herráiz, M. Angustias

doi:10.1179/147683010x12611460764129

Cited by 9 publications

(4 citation statements)

References 80 publications

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“…Our ED patients also responded in a similar way, but with specific patterns of response: While in AN patients the decrease in the number of lymphocytes was similar to that in the HC, the process was three to four times more intense in the BN patients. We consider this discordance perhaps to be due to the existence of differences in the reactivity to stress of the HPA and SAM axes in AN and BN (Garaci et al, 2019; A. M. Monteleone et al, 2015, 2017; P. Monteleone et al, 2011, 2012, 2014; Nagata, Yamada, Iketani, & Kiriike, 2006; Paszynska et al, 2016; Pirke et al, 1992; Vaz‐Leal, Rodríguez‐Santos, García‐Herráiz, & Ramos‐Fuentes, 2011; Vaz‐Leal et al, 2007, 2010; Vaz‐Leal, Rodríguez‐Santos, García‐Herráiz, Monge‐Bautista, & López‐Vinuesa, 2011). In a recent study, we reported that AN‐restricting type patients display a pattern of stress‐induced cortisol release similar to that of healthy individuals, whereas a blunted cortisol response is observed in BN patients (Vaz‐Leal et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…Patients with ED are prone to use dysfunctional and ineffective coping methods (Brytek‐Matera & Schiltz, 2013; Ghaderi & Scott, 2000; Hernando et al, 2019; Jaúregui‐Lobera, Estébanez, Santiago‐Fernández, Álvarez Bautista, & Garrido, 2009; Nagata, Matsuyama, Kiriike, Iketani, & Oshima, 2000; Tobin & Griffing, 1995; Troop, Holbrey, & Treasure, 1998). This seems to correlate with higher levels of depression, anxiety, and hostility (Dennard & Richards, 2013; Tobin & Griffing, 1995; Vaz‐Leal et al, 2007; Vaz‐Leal, Rodríguez‐Santos, Melero‐Ruiz, Ramos‐Fuentes, & García‐Herráiz, 2010), such that coping style seems to be able to identify and discriminate ED patients more effectively than the actual characteristics of the ED (Villa et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Coping strategies and stress‐induced natural killer cell redistribution in women with eating disorders

Vaz-Leal

Ramos-Fuentes

Guisado

et al. 2020

Intl J Eating Disorders

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Background: Patients with eating disorders (ED) are very sensitive and responsive to psychosocial stress. Stress response includes changes in immune cell distribution and may be modulated by the capability to cope with stressors. Thus, the present study sought to analyze the association between coping strategies and immune response (natural killer [NK] cell redistribution following psychosocial stress) in patients with anorexia nervosa (AN) and bulimia nervosa (BN) and healthy controls (HC).Method: Twenty-four AN patients, 29 BN patients, and 58 HC were studied. A multidimensional assessment tool, the COPE Inventory, was used to assess coping strategies.The number of NK cells was quantified in peripheral blood before and after the application of the Trier Social Stress Test (TSST). Potentially mediating variables, such as weight status, severity of eating pathology, depression, anxiety, and impulsivity were controlled. Results:The three groups differed in intensity and direction of cell redistribution:The TSST was followed in BN patients by a significant decrease in the number of NK cells, whereas HC displayed a moderate decrease and AN a clear increase. Specific correlations between coping strategies and NK cell mobilization were found, especially in BN patients (positive for "planning" and negative for "substance abuse").Conclusion: Recognition and subsequent modification of the dysfunctional coping strategies used by patients with ED could contribute to improving their immune status, strengthening their resilience and increasing their ability to overcome the disease. K E Y W O R D Sanorexia nervosa, bulimia nervosa, leukocyte, natural killer cells, stress, Trier Social Stress Test

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Coping strategies and stress‐induced natural killer cell redistribution in women with eating disorders

Vaz-Leal

Ramos-Fuentes

Guisado

et al. 2020

Intl J Eating Disorders

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“…The resulting defects usually require comprehensive restorative or prosthodontic treatment. Eating disorders are associated with elevated levels of pro-inflammatory cytokines such as TNF-α and IL-6, indicating a psycho-neuroimmune interplay [92,93]. Also, eating disorders are related to psychological stress and inadequate coping behaviors and are often comorbid with other psychiatric disturbances such as anxiety and depression, with a probable bidirectional interaction [94].…”

Section: Eating Disorders: Anorexia and Bulimia Nervosamentioning

confidence: 99%

Untitled

2019

EDUJ

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You are the new Director of the ERO Working Group-Continuing Medical Education in Dentistry. What are the goals you are considering? Beside Chairing the FDI ERO Working Group-Continuing Medical Education in Dentistry since 2014, I have been appointed as the new FDI Continuing Education Director for Europe right after the FDI 2018 General Assembly in Buenos Aires. Taking over the responsibility of the CE programme directory successfully run by Prof. Dr. Alexandre Mersel, I will support our member NDAs' CE events for them to assume their responsibility to perform their role with respect to the continuing education of the dental profession. Beside supporting our members both by fundamental and clinical practice-based educational activities, I will highlight our motto "Leading the world into optimal oral health" as active representatives of FDI; we need to globally improve sustainable oral health so as to reach our target. And undoubtedly one of these targets is the intent to conduct research into the knowledge about the connection between oral and general health. Therefore besides clinical dental education, we shall be pointing out the vitality of the Continuing Medical Education for the advocacy of global health and raising awareness of the dental profession with respect to the relationship between oral health and general health; one of our program goals is to strongly support improving to way these priorities are addressed by organizing CE events among our NDAs. You attended the FDI Congress in Buenos Aires. How do you assess the quality of the papers presented? What are the topics of interest to oral health specialists? FDI WDC has a broad scope mainly addressing the general practitioners at global level. Aside from the researchbased institution' s congresses, FDI WDC calls clinicians and academics to present their research and cases enabling the publication of the abstracts in the International Dental Journal (IDJ) which is the official peer-reviewed, SCIEindexed journal of FDI. Thus, all abstracts are peer-reviewed and qualified at a required scientific level. Generally, we have submissions under all clinical branches, both scientifically and clinically related abstracts and also prevention and public health-related subjects. However, concerning all the recent submissions most of them are related to clinical cases especially including novel materials and techniques used.

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“…In addition, helper/cytotoxic T cell ratio negatively correlated in this group with impulsivity, hostility, and depression. In the light of these results, the potential influence of psychopathology on lymphocyte subset counts seems to be specific in BN patients, and more relevant than in healthy controls (Vaz-Leal et al, 2010). Moreover, the complement cascade, a major component of innate immunity, represents a driving force in the pathophysiology of multiple inflammatory disorders.…”

Section: Wwwintechopencommentioning

confidence: 99%