Psychopathology and cognition in schizophrenia spectrum disorders: the role of depressive symptoms

Holthausen, Eae; Wiersma, Durk; Knegtering, Rikus; Bosch, van den Robert

doi:10.1016/s0920-9964(99)00020-1

Cited by 49 publications

(41 citation statements)

References 36 publications

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“…Some researchers have suggested that a threedimension model of schizophrenia psychopathology is too limited, and in addition to these three symptom dimensions a depression dimension has been reported in schizophrenia (59). Although its relationship with cognitive functioning has not been studied extensively yet, depression has consistently been found to affect cognitive functioning, and two studies on cognitive functioning in schizophrenia that included depressive symptoms reported that these symptoms were associated with a reduced performance on cognitive measures (59,60). Thus part of the reported psychopathological associations may be reducible in part to the effect of depression.…”

Section: Limitationsmentioning

confidence: 99%

Cognitive alterations in groups at risk for psychosis: neutral markers of genetic risk or indicators of social disability?

Jabben

Janssen

et al. 2007

Acta Psychiatr Scand

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Section: Limitationsmentioning

confidence: 99%

Cognitive alterations in groups at risk for psychosis: neutral markers of genetic risk or indicators of social disability?

Jabben

Janssen

et al. 2007

Acta Psychiatr Scand

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“…[12][13][14] However, several studies failed to reveal such a relationship. [15][16][17][18] Discrepancies may arise from differences in the scales used to assess depression, as well as from confounding factors, such as general verbal ability, or use of anticholinergic medication. Drugs with anticholinergic properties appear to affect verbal memory efficiency, 19 notably by impeding semantic organization of the material.…”

mentioning

confidence: 99%

Depression, Avolition, and Attention Disorders in Patients with Schizophrenia: Associations with Verbal Memory Efficiency

Brébion¹,

Bressan²,

Pilowsky³

et al. 2009

JNP

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The authors undertook a study of the clinical correlates of verbal memory deficits in schizophrenia. The first purpose was to replicate the finding of a significant association between depression and impairment in the deep encoding memory processes. The second purpose was to test the hypothesis that certain clinical symptoms--avolition, disorders of attention--also play a role in verbal memory impairment, distinct from a global negative symptomatology score. Forty-one patients with schizophrenia underwent a memory task including forward digit span and learning lists of words with different levels of semantic organization. Regression analyses revealed that the depression score was associated with the total number of recalled words, whereas the global negative symptom score was not. Depression score was not associated with the forward digit span, a measure of superficial serial encoding processes. An analysis of individual symptoms from the Scale for the Assessment of Negative Symptoms (SANS) indicated that avolition was associated with several memory scores, suggesting a pervasive effect of this symptom. Attention disorders were associated with impaired efficiency in serial learning, but not with word recall efficiency. It is suggested that more consideration should be given to depression and motivation in the investigation of cognitive impairment in schizophrenia, as well as in cognitive remediation strategies.

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“…It is possible, that following atypical movement requires more mental effort from patients than controls. 19 Therefore, in future applications it is reasonable to expect higher discriminative power in the case of classification based on coordination measures if the movement of the leader is atypical and less familiar, e.g. as in our case slower and with shorter physical range.…”

Section: Resultsmentioning

confidence: 93%

Unravelling socio-motor biomarkers in schizophrenia

et al. 2017

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We present novel, low-cost and non-invasive potential diagnostic biomarkers of schizophrenia. They are based on the ‘mirror-game’, a coordination task in which two partners are asked to mimic each other’s hand movements. In particular, we use the patient’s solo movement, recorded in the absence of a partner, and motion recorded during interaction with an artificial agent, a computer avatar or a humanoid robot. In order to discriminate between the patients and controls, we employ statistical learning techniques, which we apply to nonverbal synchrony and neuromotor features derived from the participants’ movement data. The proposed classifier has 93% accuracy and 100% specificity. Our results provide evidence that statistical learning techniques, nonverbal movement coordination and neuromotor characteristics could form the foundation of decision support tools aiding clinicians in cases of diagnostic uncertainty.

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Psychopathology and cognition in schizophrenia spectrum disorders: the role of depressive symptoms

Cited by 49 publications

References 36 publications

Cognitive alterations in groups at risk for psychosis: neutral markers of genetic risk or indicators of social disability?

Cognitive alterations in groups at risk for psychosis: neutral markers of genetic risk or indicators of social disability?

Depression, Avolition, and Attention Disorders in Patients with Schizophrenia: Associations with Verbal Memory Efficiency

Unravelling socio-motor biomarkers in schizophrenia

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