Exciting findings in recent research in neurobiology do not regularly appear in the social and psychological sciences literature. Yet, there is neurobiological evidence that variously supports, qualifies, and elaborates on the understanding of dynamic treatment. Early in his career, Freud lamented that the science necessary to support and advance his theorizing in the psychological realm would only become available to future generations. A case in point is that recent findings reveal that neurobiological transformations in the brain can result from specific and focused relationship interactions. Addressed here are some biological phenomena which seem to lend support for the following analytic hypotheses: structural theory (id, ego, super-ego), defense mechanisms, object relations, free association, transference, countertransference, the therapeutic alliance, and working through.