Psychopathological profile in children with Prader-Willi syndrome as compared with autism spectrum disorder

Bechis, Daniela; Baietto, Chiara; Caldarera, Angela Maria; Vitiello, Benedetto

doi:10.23736/s2724-5276.21.06447-8

Cited by 1 publication

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“…Insistence on sameness in routines/events and compulsivity were seen in 76–100% of this sample (± autism), appearing related to physiological challenges, including hyperphagia and emotional regulation [ 66 ]. Strong interests described as ‘intense obsessionality’ are more marked in PWS than non-syndromic autism [ 67 ]. Psychiatric conditions also frequently co-occur, the most common being anxiety, expressed through difficulties with transitions, skin picking, and repetitive questioning [ 68 ].…”

Section: Broader Phenotypic Characteristicsmentioning

confidence: 99%

Heterogeneity of Autism Characteristics in Genetic Syndromes: Key Considerations for Assessment and Support

Jenner

Richards

Howard

et al. 2023

Curr Dev Disord Rep

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Purpose of Review Elevated prevalence of autism characteristics is reported in genetic syndromes associated with intellectual disability. This review summarises recent evidence on the behavioural heterogeneity of autism in the following syndromes: Fragile X, Cornelia de Lange, Williams, Prader-Willi, Angelman, Down, Smith-Magenis, and tuberous sclerosis complex. Key considerations for assessment and support are discussed. Recent Findings The profile and developmental trajectory of autism-related behaviour in these syndromes indicate some degree of syndrome specificity which may interact with broader behavioural phenotypes (e.g. hypersociability), intellectual disability, and mental health (e.g. anxiety). Genetic subtype and co-occurring epilepsy within syndromes contribute to increased significance of autism characteristics. Autism-related strengths and challenges are likely to be overlooked or misunderstood using existing screening/diagnostic tools and criteria, which lack sensitivity and specificity within these populations. Summary Autism characteristics are highly heterogeneous across genetic syndromes and often distinguishable from non-syndromic autism. Autism diagnostic assessment practices in this population should be tailored to specific syndromes. Service provisions must begin to prioritise needs-led support.

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Section: Broader Phenotypic Characteristicsmentioning

confidence: 99%