Psychoneuroimmunological Processes in Coronary Artery Disease and Heart Failure

Kop, Willem J.; Mommersteeg, Paula M.C.

doi:10.1002/9781118314814.ch26

Cited by 3 publications

(8 citation statements)

References 76 publications

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“…Часть иммунологических изменений объясняется также наличием ожирения, хронической вирусной инфекции (герпес, цитомегаловирус). Так называемое болезненное состояние (sickness behavior) объясняет связь депрессивных состояний с воспалением [11]. Следует также отметить кинурениновую теорию развития депрессии.…”

Section: воспалениеunclassified

“…Выделяются также острые психологические факторы (острый стресс, вспышки гнева). Их иммунологическое проявление состоит в повышении количества CD8+ Т-клеток и В-клеток, снижении CD4+ Т-клеток, повышении уровня цитокинов ИЛ-1β, ИЛ-2, молекул адгезии, белков острой фазы [11].…”

Section: воспалениеunclassified

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A Psychosomatic Vicious Circle of Myocardial Infarction

Таратухин¹,

Гордеев²,

Лебедева³

2018

Russ J Cardiol

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Представлен обзор исследований, демонстрирующих соматические изменения при психологических процессах, принятых как факторы риска острого инфаркта миокарда: депрессия, стресс, тревога. На основании метафорического обозначения "идеальный шторм" показаны воспалительные, иммунологические, нейрогуморальные предпосылки развития инфаркта миокарда, а равно таковые изменения, являющиеся соматическим субстратом психологических состояний, способствующих развитию инфаркта миокарда посредством поведенческих и биологических факторов риска: "болезненное поведение", "депрессионная болезнь". Два эти процесса входят в психосоматический "порочный круг". В статье делается акцент на важности индивидуализации подхода к реабилитации и вторичной профилактике инфаркта миокарда, поскольку с биопсихосоциальной точки зрения восходящие и нисходящие психосоматические связи у каждого пациента уникальны.

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Section: воспалениеunclassified

A Psychosomatic Vicious Circle of Myocardial Infarction

Таратухин¹,

Гордеев²,

Лебедева³

2018

Russ J Cardiol

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“…A substantial number of clinical studies have clearly established the involvement of cytokines in the pathophysiology of major depression and ischemic CVD with and without comorbid depression [ 6 – 8 ]. Evidence shows that proinflammatory cytokines are important determinants of severity and prognosis of CVD [ 9 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Plasma levels of cytokines are strong predictors of patients’ functional class (NYHA) and also predictors of left ventricular function (LVEF) decline [ 12 ]. Furthermore, and maybe even more important, a growing body of evidence indicate that the association of psychological risk factors with adverse cardiovascular events is due to immunological processes, specifically inflammation [ 4 , 6 , 7 , 13 – 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…Considering the important role that inflammation has in the pathogenesis of psychosomatic disorders, it may follow that the observed associations between psychosomatic syndromes and HF are affected by greater inflammatory activity. Furthermore, given existing evidence that the association between depression and psychological factors with adverse cardiovascular events in HF is partly attributable to inflammation [ 4 , 6 , 13 , 14 ], we examined the relation between depression, psychological variables, and the circulating levels of cytokines, in patients with HF. We used serum levels of IL-6 and TNF-alpha as markers of inflammation because multiple lines of evidence indicate that those cytokines have been found to be major prognostic markers in HF [ 9 , 25 , 26 , 29 , 60 ] and associated with the development of psychosomatic symptoms [ 40 , 51 ].…”

Section: Introductionmentioning

confidence: 99%

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Psychosomatic syndromes are associated with IL-6 pro-inflammatory cytokine in heart failure patients

et al. 2022

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Psychosomatic syndromes have emerged as an important source of comorbidity in cardiac patients and have been associated with increased risk for adverse outcomes in patients with heart failure (HF). Understanding of the mechanisms underlying this connection is limited, however immune activity represents a possible pathway. While there have been numerous studies connecting immune activity to psychosomatic psychopathology, there is a lack of research on patients with HF. We examined forty-one consecutive outpatients affected by HF. We assessed psychosomatic psychopathology using the Diagnostic Criteria for Psychosomatic Research (DCPR) and the Patient Health Questionnaire-15 (PHQ-15). The Psychosocial Index (PSI) was used for assessing stress and psychosocial dimensions. Depression was evaluated with Beck Depression Inventory-II (BDI-II). Circulating levels of proinflammatory cytokines IL-6 and TNF-alpha were ascertained. Univariate and multivariable regression models were used to test for associations between inflammatory cytokines and psychosomatic psychopathology (i.e., DCPR syndromes, PHQ-15) and psychological dimensions (i.e., BDI-II, PSI). A significant positive correlation was found between IL-6 levels and psychosomatic psychopathology even when controlling for any confounding variables (i.e., Body-mass index (BMI), New York Heart Association (NYHA) class, smoking habits, alcohol consumption, statin use, aspirin use, beta blockers use, age, and gender). In contrast, the associations between TNF-alpha levels were non-significant. These findings can contribute to research in support of a psychoneuroimmune connection between psychosomatic psychopathology and HF. Findings also suggest the possibility that elevated IL-6 levels are more relevant for the pathogenesis of psychosomatic syndromes than for depression in patients with HF.

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