Psychomotor stimulants and neuronal plasticity

Wolf, Marina E.; Sun, Xiu; Mangiavacchi, Simona; Chao, Steven

doi:10.1016/j.neuropharm.2004.07.006

Cited by 250 publications

(209 citation statements)

References 154 publications

Supporting

Mentioning

201

Contrasting

Unclassified

Order By: Relevance

“…Based on these findings, we hypothesize that there exists a hyperglutamatergic state within the mesocorticolimbic pathway during chronic nicotine SA (Kalivas, 2004). This may be involved in aspects of drug SA, such as sensitization, that reflect the occurrence of increasing neuronal plasticity with duration of exposure (Wolf et al, 2004). Further investigation will be needed to evaluate the neurochemical changes underlying this hypothesis.…”

Section: Discussionmentioning

confidence: 95%

Upregulation of Ionotropic Glutamate Receptor Subunits within Specific Mesocorticolimbic Regions during Chronic Nicotine Self-Administration

Wang

Chen

Steketee

et al. 2006

Neuropsychopharmacol

119

View full text Add to dashboard Cite

Nicotine, an addictive substance, is the major psychoactive component in cigarette smoke. Both a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid and N-methyl-D-aspartate (NMDA) receptors are essential for the acute stimulative effects of nicotine on the mesocorticolimbic dopamine system, yet little is known about the effects of chronic nicotine treatment on glutamate receptors. Therefore, we used a model of chronic nicotine self-administration (SA), which emulates important aspects of nicotine intake by humans, to determine whether glutamate receptor subunits were affected. After 18 days of saline vs nicotine SA, ionotropic glutamate receptor subunit levels were determined in brain regions within the mesocorticolimbic system by Western blotting. In prefrontal cortex (PFC), the levels of NMDA receptor subunit 2A (NR2A) and NR2B were increased by 67% (p ¼ 0.04) and 83% (p ¼ 0.027), respectively. In the ventral tegmental area (VTA), glutamate receptor subunit 2/3 (GluR2/3) increased by 34% (p ¼ 0.011). Nicotine SA did not affect the expression of these subunits in dorsal striatum and nucleus accumbens. These findings suggest that chronic nicotine SA selectively increased the levels of ionotropic glutamate receptor subunits in a brain region-specific manner.

show abstract

Section: Discussionmentioning

confidence: 95%

Upregulation of Ionotropic Glutamate Receptor Subunits within Specific Mesocorticolimbic Regions during Chronic Nicotine Self-Administration

Wang

Chen

Steketee

et al. 2006

Neuropsychopharmacol

119

View full text Add to dashboard Cite

show abstract

“…Future work in this area of investigation may incorporate microsensor technology, which may be more sensitive than microdialysis to neuronally-derived glutamate (Oldenziel et al, 2006). It is known that the NAcc and related neural pathways are involved in the psychostimulant effects of amphetamine (Wolf, 1998;Rockhold et al, 1998;Wolf et al, 2004;Kalivas and Volkow, 2005). Neuroanatomical studies have indicated that DA neurons in the NAcc receive significant glutamatergic input directly from the limbic cortex and sub-cortical structures (Groenewegen et al 1980;Kelley and Domesick 1982;Kita and Kitai 1990;Parent and Hazrati, 1995;Sesack et al, 1989;Tzschentke and Schmidt, 2000).…”

Section: Discussionmentioning

confidence: 99%

Environmental enrichment increases amphetamine-induced glutamate neurotransmission in the nucleus accumbens: A neurochemical study

Rahman

Bardo

2008

Brain Research

View full text Add to dashboard Cite

In addition to dopamine (DA), evidence indicates that glutamatergic regulation of the mesolimbic reward pathway is involved in mediating the abuse-related effects of psychostimulants, including amphetamine. Since rats raised in an enrichment condition (EC) during development are more sensitive to the locomotor stimulant effects of acute amphetamine compared to rats raised in an impoverished condition (IC), the present study examined amphetamine-induced extracellullar glutamate and aspartate levels in the nucleus accumbens (NAcc) of EC and IC rats using in vivo microdialysis coupled with HPLC-electrochemical detection. Basal extracellular levels of glutamate or aspartate were not significantly different between EC and IC rats. Acute systemic amphetamine (0.5 or 2.0 mg/kg, sc) increased extracellular glutamate levels in NAcc of EC rats (137% or 305% of basal) and IC rats (120% or 187% of basal). Similarly, acute systemic amphetamine (0.5 or 2.0 mg/kg, sc) elevated aspartate levels in NAcc of EC rats (148% or 237% of basal) and IC rats (115% or 170% of basal). Glutamate levels were elevated by amphetamine to a greater extent in EC rats than in IC rats. Pretreatment with systemic MK-801 (0.25 mg/kg, ip), a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, prevented the acute amphetamine-induced increase in extracellular glutamate and aspartate levels in NAcc. Overall, these results suggest that alterations in glutamate in the NAcc may be involved in the environment-dependent effects of amphetamine.

show abstract

“…The varied effects of perinatal lead exposure on the phenomenology of self-administration of various psychoactive drugs is not altogether surprising given the complexity of the patterns of neuroadaptation associated with chronic drug taking (Self, 2004;Wolf et al, 2004). What is at issue is identifying the precise effects of lead exposure on mechanisms underlying functional changes in sensitivity to drugs possessing abuse liability.…”

Section: Discussionmentioning

confidence: 99%

Developmental lead exposure alters methamphetamine self-administration in the male rat: Acquisition and reinstatement

Rocha

Valles

Bratton

et al. 2008

Drug and Alcohol Dependence

View full text Add to dashboard Cite

The rate of acquisition of drug self-administration and the return to drug seeking are important elements of the overall drug profile, and are essential factors in understanding risks associated with drug abuse. Experiment 1 examined the effects of perinatal (gestation/lactation) lead exposure on adult rates of acquisition of intravenous (i.v.) methamphetamine self-administration. Experiment 2 investigated the effects of perinatal lead exposure on drug-maintained responding in a reinstatement (relapse) paradigm. In Experiment 1, female rats were gavaged daily with 0 or 16-mg lead for 30 days prior to breeding with nonexposed males. Lead exposure continued through gestation and lactation and was discontinued at weaning (postnatal day [PND] 21). Male rats born to control or lead-exposed dams were tested daily as adults in an acquisition paradigm that incorporated both Pavlovian and operant components. An initial 3-hr autoshaping period preceded a 3-hr selfadministration period. For 35 daily training sessions i.v. methamphetamine infusions [inf] (0.02 mg/ kg) were paired with the extension and retraction of a lever (autoshaping), while inf occurred during self-administration only when a lever press was executed (FR-1). In Experiment 2 animals developmentally exposed to lead were trained on a FR-2 to self-administer methamphetamine (0.04 mg/kg/inf) and then placed on an extinction schedule prior to receiving intraperitoneal (i.p.) priming injections of saline, 0.50, 1.00, or 1.50 mg/kg methamphetamine. The findings from Experiment 1 showed that acquisition was delayed in rats born to lead-exposed dams gavaged daily with 16-mg lead throughout gestation and lactation when a 0.02 mg/kg/inf of methamphetamine served as the reinforcement outcome. Additional data from Experiment 2 indicated priming cues (injections of methamphetamine [i.p.]) administered after extinction were less likely to occasion a return to drug seeking (relapse) in the 16-mg group relative to the 0-mg control group. These results suggest perinatal lead exposure alters patterns of methamphetamine self-administration during the adult cycle.

show abstract

Psychomotor stimulants and neuronal plasticity

Cited by 250 publications

References 154 publications

Upregulation of Ionotropic Glutamate Receptor Subunits within Specific Mesocorticolimbic Regions during Chronic Nicotine Self-Administration

Upregulation of Ionotropic Glutamate Receptor Subunits within Specific Mesocorticolimbic Regions during Chronic Nicotine Self-Administration

Environmental enrichment increases amphetamine-induced glutamate neurotransmission in the nucleus accumbens: A neurochemical study

Developmental lead exposure alters methamphetamine self-administration in the male rat: Acquisition and reinstatement

Contact Info

Product

Resources

About