Psychomotor retardation and anhedonia in depression

Lemke, Matthias R.; Puhl, P.; Koethe, N.; Winkler, Torsten

doi:10.1111/j.1600-0447.1999.tb07221.x

Cited by 69 publications

(41 citation statements)

References 22 publications

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“…In addition, we investigate this dependence with respect to each of the symptom-specific components that comprise the standard 17-item HAMD [13] composite assessment of depression. For example, supporting the premise that psychomotor retardation can be observed in the speech rate [12,14], we reveal high correlations between not only the global speech rate, but also between a subset of individual phone durations and the HAMD Psychomotor Retardation sub-topic. Although the specific focus in this article is on biomarkers derived from speech rate, we provide a general framework in which to explore the relationship between phonologically-based biomarkers and the severity of individual MDD symptoms.…”

Section: Introductionsupporting

confidence: 56%

Phonologically-based biomarkers for major depressive disorder

Trevino

Quatieri

Malyska

2011

EURASIP J. Adv. Signal Process.

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Of increasing importance in the civilian and military population is the recognition of major depressive disorder at its earliest stages and intervention before the onset of severe symptoms. Toward the goal of more effective monitoring of depression severity, we introduce vocal biomarkers that are derived automatically from phonologically-based measures of speech rate. To assess our measures, we use a 35-speaker free-response speech database of subjects treated for depression over a 6-week duration. We find that dissecting average measures of speech rate into phone-specific characteristics and, in particular, combined phone-duration measures uncovers stronger relationships between speech rate and depression severity than global measures previously reported for a speech-rate biomarker. Results of this study are supported by correlation of our measures with depression severity and classification of depression state with these vocal measures. Our approach provides a general framework for analyzing individual symptom categories through phonological units, and supports the premise that speaking rate can be an indicator of psychomotor retardation severity.

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Section: Introductionsupporting

confidence: 56%

Phonologically-based biomarkers for major depressive disorder

Trevino

Quatieri

Malyska

2011

EURASIP J. Adv. Signal Process.

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“…Depressive symptoms may impair cognition [32]. In addition, some studies found specific associations between depression severity and PS in different major psychiatric disorders [33,34], while others did not [35,36]. The depressive symptoms in the present study correlated with MT in the figure-copying tasks.…”

Section: Discussionsupporting

confidence: 68%

Unraveling Psychomotor Slowing in Bipolar Disorder

et al. 2015

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Background/Aims: In addition to affective and cognitive symptomatology, psychomotor deficits are known to be present in bipolar disorder (BD). Psychomotor functioning includes all of the processes necessary for completing a movement, from planning to initiation and execution. While these psychomotor symptoms have been studied extensively in schizophrenia and major depressive disorder, only simple measures have been conducted in BD. The present study examines psychomotor functioning in BD. Methods: Twenty-two euthymic BD patients and 21 healthy controls performed three computerized copying tasks varying in cognitive load. Movement times (MT), reflecting fine motor processing, and initiation times (IT), reflecting cognitive processing of visual-spatial information, were separately measured in each group. Results: The BD patients had longer IT but not MT in the simplest task and the opposite pattern of longer MT but not IT in the complex task. However, when controlling for residual mood symptoms, the MT were no longer significantly slower in the BD group. Conclusions: The longer MT and IT in BD reflect overall psychomotor slowing. Specifically, the results provide evidence for cognitive slowing in BD. In addition, the longer MT in the complex task reflect a slowed motor component of movement when the cognitive load is high and when depressive symptoms are present. These findings extend the current knowledge of the nature of psychomotor slowing in BD and may have important prognostic implications for patients.

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“…Thus, evidence supports the specificity and clinical plausibility of the ''agitated depression'' phenotype (MDD with PMA), which is best characterized by irritability, anxiety, and increased arousal as well as a propensity toward the bipolar spectrum and substance use. In contrast, investigations of depressed samples indicate that PMR is more strongly associated with anhedonia [Benazzi, 2002;Lemke et al, 1999;Luby et al, 2004], lack of mood reactivity [Benazzi, 2002], cognitive disturbance [Caligiuri and Ellwanger, 2000;Narita et al, 2004], and melancholic symptoms [Parker et al, 1995;Sobin et al, 1998] than other symptoms. In samples including individuals with and without mood disorders, PMR is most strongly associated with fatigue, low mood, anhedonia, and concentration difficulties [Zimmerman et al, 2006].…”

Section: Introductionmentioning

confidence: 89%

Characterizing major depression phenotypes by presence and type of psychomotor disturbance in adolescents and young adults

2008

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Major depressive disorder (MDD) is phenomenologically heterogeneous, which has prompted investigation of intermediate MDD phenotypes based on specific key symptoms. Presence and type of psychomotor disturbance may be an important psychopathologic feature that differentiates clinically distinct forms of juvenile MDD. This study examined the phenotypic status of three putative MDD phenotypes in a community sample of 941 youths: (1) agitated depression (MDD with psychomotor agitation), (2) retarded depression (MDD with psychomotor retardation), and (3) agitated-retarded depression (MDD with psychomotor agitation and retardation within an episode). Hasler et al.'s [2004: Neuropsychopharmacology 29:1765-1781] criteria of specificity (degree of association with relevant symptoms and conditions related to the disease of interest versus other psychiatric conditions), stability (degree of stability over time), and heritability (degree of familial aggregation with relevant conditions) were used to evaluate the phenotypic significance of these subtypes. Results were suggestive that agitated depression was a relatively specific phenotypic syndrome characterized by irritability, arousal, physical complaints, and vulnerability to anxiety disorders and alcohol dependence; low stability across depressive episodes; and low heritability. Agitated-retarded depression was relatively specific and characterized by increased severity, recurrence, vegetative symptoms, suicidal ideation, social impairment, endogeneity, and vulnerability to anxiety disorders and bulimia; low stability across episodes; and modest heritability. Although retarded depression was associated with some specific distinguishing characteristics, most associations were explained by the increased severity of this phenotype. Retarded depression evidenced little stability or heritability. These findings offer partial support of the phenotypic status of agitated and agitated-retarded depression in youths.

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Psychomotor retardation and anhedonia in depression

Cited by 69 publications

References 22 publications

Phonologically-based biomarkers for major depressive disorder

Phonologically-based biomarkers for major depressive disorder

Unraveling Psychomotor Slowing in Bipolar Disorder

Characterizing major depression phenotypes by presence and type of psychomotor disturbance in adolescents and young adults

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