Psychomotor functions in developing rats: Ontogenetic approach to structure-function relationships

Bâ, Abdoulaye; Seri, Bialli

doi:10.1016/0149-7634(94)00042-y

Cited by 67 publications

(37 citation statements)

References 66 publications

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“…Unlike the work of Westerga and Gramsbergen (1990), our study allowed us to verify the overall performance of the animal through the parameters of distance, speed and potency. Our results are in accordance with the literature on increased exploration activity and interaction with the environment between weaning and the 30th postnatal day (Bâ and Seri, 1995).…”

Section: Discussionsupporting

confidence: 96%

Automatic system for analysis of locomotor activity in rodents—A reproducibility study

Aragão

Rodrigues

Barros

et al. 2011

Journal of Neuroscience Methods

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Automatic analysis of locomotion in studies of behavior and development is of great importance because it eliminates the subjective influence of evaluators on the study. This study aimed to develop and test the reproducibility of a system for automated analysis of locomotor activity in rats. For this study, 15 male Wistar were evaluated at P8, P14, P17, P21, P30 and P60. A monitoring system was developed that consisted of an open field of 1m in diameter with a black surface, an infrared digital camera and a video capture card. The animals were filmed for 2 min as they moved freely in the field. The images were sent to a computer connected to the camera. Afterwards, the videos were analyzed using software developed using MATLAB® (mathematical software). The software was able to recognize the pixels constituting the image and extract the following parameters: distance traveled, average speed, average potency, time immobile, number of stops, time spent in different areas of the field and time immobile/number of stops. All data were exported for further analysis. The system was able to effectively extract the desired parameters. Thus, it was possible to observe developmental changes in the patterns of movement of the animals. We also discuss similarities and differences between this system and previously described systems.

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Section: Discussionsupporting

confidence: 96%

Automatic system for analysis of locomotor activity in rodents—A reproducibility study

Aragão

Rodrigues

Barros

et al. 2011

Journal of Neuroscience Methods

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“…These fi ndings were expected, as the ontogeny of locomotor behavior continues until at least 30 days of age [Bâ and Seri, 1995;Clarke and Williams, 1994]. The lack of a treatment effect on arm entry supports prior fi ndings by indicating that glucose does not infl uence activity and extends this fi nding from adult animals to 20-to 24-day-old animals.…”

Section: Discussionsupporting

confidence: 70%

Effects of Aging and <i>D</i>-Glucose on Locomotor Activity, Spontaneous Alternation, and Plasma Glucose Levels in Preweanling Sprague-Dawley Rats

Flint¹,

Papandrea²,

Dorr³

2006

Dev Neurosci

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Previous research has shown that developmentally related memory impairments in immature rodents are malleable and may be attenuated using a variety of pharmacological and behavioral treatments. This experiment examined the effects of glucose (10, 100, 250 or 500 mg/kg) or saline on blood glucose level, locomotor activity, and spontaneous alternation (SA) in the T-maze. Studies were conducted with 20-, 22-, and 24-day-old preweanling Sprague-Dawley rats. Results indicated a general decline in blood glucose level with age and size of glucose injection. The largest overall decline in blood glucose was found following the 500 mg/kg dose in 24-day-old animals. An increase in T-maze arm entries with age indicated increased exploratory activity. SA generally improved with age, but glucose had no reliable effect on behavior. The ontogenetic state of the nervous system, including changes in cholinergic system activity, glucoregulation, and proliferation of glucose transporters, is discussed.

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“…Identified cases of prodromal schizophrenia and depression are often characterized by marked problems with working memory and social withdrawal. Adult levels of executive function emerge relatively late in the postnatal development of humans (63), nonhuman primates (19), and rodents (64). Preclinical studies show that this delay in achieving mature performance on executive function tasks correlates with the maturation of PVB-interneuronal networks throughout childhood and adolescence (41,65–67).…”

Section: Discussionmentioning

confidence: 99%

Nonsteroidal Anti-Inflammatory Treatment Prevents Delayed Effects of Early Life Stress in Rats

Brenhouse

Andersen

2011

Biological Psychiatry

115

141

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Background Early developmental insults can cause dysfunction within parvalbumin (PVB)-containing interneurons in the prefrontal cortex. The neuropsychiatric disorders associated with such dysfunction might involve neuroinflammatory processes. Cyclooxygenase-2 (COX-2) is a key mediator of inflammation and is therefore a potential target for preventive treatment. Here, we investigated whether the developmental trajectories of PVB expression and COX-2 induction in the prelimbic region of the prefrontal cortex are altered after maternal separation stress in male rats. Methods Male rat pups were separated from their mother and littermates for 4 hours/day between postnatal Days 2 and 20. Western blotting and immunohistochemistry were used to analyze PVB and COX-2 expression in the prefrontal cortex and hippocampus. A separate cohort of animals was treated with a COX-2 inhibitor during preadolescence and analyzed for PVB, COX-2, and working memory performance. Results We demonstrate that maternal separation causes a reduction of PVB and an increase in COX-2 expression in the prefrontal cortex in adolescence, with concurrent working memory deficits. Parvalbumin was not affected earlier in development. Prophylactic COX-2 inhibition preadolescence prevents PVB loss and improves working memory deficits induced by maternal separation. Conclusions These data are the first to show a preventive pharmacological intervention for the delayed effects of early life stress on prefrontal cortex interneurons and working memory. Our results suggest a possible mechanism for the relationship between early life stress and interneuron dysfunction in adolescence.

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Psychomotor functions in developing rats: Ontogenetic approach to structure-function relationships

Cited by 67 publications

References 66 publications

Automatic system for analysis of locomotor activity in rodents—A reproducibility study

Automatic system for analysis of locomotor activity in rodents—A reproducibility study

Effects of Aging and <i>D</i>-Glucose on Locomotor Activity, Spontaneous Alternation, and Plasma Glucose Levels in Preweanling Sprague-Dawley Rats

Nonsteroidal Anti-Inflammatory Treatment Prevents Delayed Effects of Early Life Stress in Rats

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