Psychomotor Activity and Cerebrospinal Fluid Amine Metabolites in Affective Illness

Post, Robert M.; Kotin, Joel; Goodwin, Frederick K.; Gordon, Edna K.

doi:10.1176/ajp.130.1.67

Cited by 263 publications

(80 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several credible physiologic and psychological mechanisms have been described, such as the thermogenic hypothesis, 36 the endorphin hypothesis, 37,38 the monoamine hypothesis, [39][40][41][42] the distraction hypothesis, 43 and the enhancement of self-efficacy. 29,[43][44][45][46] However, there is little research evidence to either support or refute most of these theories.…”

Section: Proposed Mechanisms For the Exercise-depression Relationshipmentioning

confidence: 99%

The Benefits of Exercise for the Clinically Depressed

Craft

Perna²

2004

Prim. Care Companion CNS Disord.

462

322

View full text Add to dashboard Cite

Section: Proposed Mechanisms For the Exercise-depression Relationshipmentioning

confidence: 99%

The Benefits of Exercise for the Clinically Depressed

Craft

Perna²

2004

Prim. Care Companion CNS Disord.

462

322

View full text Add to dashboard Cite

“…Demographic and clinical characteristics and CSF monoamine metabolites in depressed subjects with and without a history of alcoholism and healthy volunteers were compared using a general linear model. We compared CSF HVA in the two depressed groups controlling for sex, aggression, and depression (HDRS) scores, tobacco smoking, antisocial and borderline personality disorders, psychomotor retardation, and delusions because studies have suggested that these parameters may affect the CSF HVA content (Raleigh et al, 1992;Nordin et al, 1995;Seegal, 1985;Campanella et al, 1977;Lindstrom, 1985;Aberg-Wistedt et al, 1985;Houston et al, 1986;Almay et al, 1987;Jones et al, 1990;Faustman et al, 1991;Limson et al, 1991;Spiegel and King, 1992;Johnson et al, 1994;Soderstrom et al, 2001;Kapur and Mann, 1992;Brown and Gershon, 1993;Lykouras et al, 1994;van Praag et al, 1975;Post et al, 1973;Chotai et al, 1998;Daderman and Lidberg, 2002;Geracioti et al, 1999). Suicide attempt status was evaluated using the chisquared test.…”

Section: Statistical Analysesmentioning

confidence: 99%

Lower CSF Homovanillic Acid Levels in Depressed Patients with a History of Alcoholism

Sher

Oquendo

et al. 2003

Neuropsychopharmacol

View full text Add to dashboard Cite

Major depression and alcoholism are often comorbid, resulting in more impairment and more suicidal behavior compared with either diagnosis alone. This study compared clinical features and cerebrospinal fluid (CSF) monoamine metabolites in depressed subjects with and without a history of alcoholism and healthy volunteers. We hypothesized that depressed subjects with a history of alcoholism would be more aggressive, impulsive, and suicidal than depressed subjects without a history of alcoholism, and would have lower CSF monoamine metabolite levels. We compared 63 subjects with a current major depressive episode (MDE) and a history of alcoholism, 72 subjects with a current MDE but without a history of alcoholism, and 22 healthy volunteers. Participants with a history of alcoholism were in remission for at least 6 months. All subjects were free from prescribed medications known to affect brain serotonin, dopamine, or norepinephrine systems for a minimum of 14 days. Depressive symptoms, lifetime aggression, impulsivity, Axis II disorders, and suicidal behavior were assessed. CSF was sampled and homovanillic acid (HVA), 5-hydroxyindolacetic acid (5-HIAA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) were assayed by high-performance lipid chromatography with electrochemical detection. Depressed subjects with a history of alcoholism did not differ from depressed subjects without a history of alcoholism in current severity of depressive symptoms, or in past suicidal behavior. Depressed subjects with a history of alcoholism had lower CSF HVA levels, and higher lifetime aggression and current suicide ideation scale scores and were more likely to be tobacco smokers compared with depressed subjects without a history of alcoholism. Low HVA was present after adjustment for sex, aggression and depression scores, cigarette smoking, antisocial and borderline personality disorders, psychomotor retardation, and delusions. Controls had CSF HVA levels intermediate between the two depressed groups. We found no group difference in CSF 5-HIAA and MHPG levels. In individuals with current MDE, those with a history of comorbid alcoholism had lower CSF HVA levels compared with those without a history of alcoholism. Low CSF HVA suggests that impaired dopaminergic activity is associated with a history of alcoholism in persons with current MDE.

show abstract

“…In the cerebrospinal fluid of depressed patients, the concentration of the serotonin metabolite 5-HIAA was significantly higher after 4 hours of motor activity than in the same patients after bed rest (Post et al 1973). Aerobic exercise causes a rise of free fatty acids Fischer et al From the Department of Psychiatry, University of Göttingen, Göt-tingen, Germany (AB, DM, BB, GH, UB, ER), the Department of Neurology (AG), University of Würzburg, Würzburg, Germany; the Department of Clinical Pharmacology (CHG), Department of Sports Medicine (UH-V), University of Göttingen, Göttingen, Germany; Institute of Sports and Preventive Medicine (TM), University of Saarbrücken, Saarbrücken, Germany.…”

Section: Several Clinical Studies Suggest Antidepressive and Anxiolytmentioning

confidence: 77%

“…In the cerebrospinal fluid of depressed patients, concentrations of the serotonin metabolite 5-HIAA and the norepinephrine metabolite vanillylmandelic acid (VMA) were significantly higher after 4 hours of hyperactivity than in the same patients after bed rest (Post et al 1973). Also, urinary and CSF MHPG was significantly higher during a day of increased motor activity in comparison with a day with usual ward activities in depressed patients (Beckmann et al 1979).…”

Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 99%

See 1 more Smart Citation

Decreased Neuroendocrine Responses to Meta-Chlorophenylpiperazine (m-CPP) but Normal Responses to Ipsapirone in Marathon Runners

Broocks

Meyer²,

George

et al. 1999

Neuropsychopharmacology

View full text Add to dashboard Cite

Several clinical studies suggest antidepressive and anxiolytic effects of regular aerobic exercise. To study the effects of exercise on central serotonergic receptor sensitivity, we performed neuroendocrine challenges using oral doses of meta-chlorophenylpiperazine (m-CPP, 0.4 mg/ kg), ipsapirone (0.3 mg/kg) and placebo in 12 marathon runners and 12 healthy controls not practicing regular exercise. After administration of the nonselective serotonergic agonist m-CPP, which exerts a number of wellreproducible effects mainly by means of its action on 5-HT Meta-chlorophenylpiperazine (m-CPP); Ipsapirone Several studies of healthy volunteers have shown a positive effect of endurance training on anxiety, depressive symptoms, self-esteem, concentration, sexual satisfaction, and stress tolerance (de Coverley Veale 1987;Farmer et al. 1988;Hughes 1984;Lennox et al. 1990;MacMahon 1990;Sothman et al. 1992). There is also some evidence that exercise is effective against mild-to-moderate depression and against anxiety disorders (Doyne et al. 1987;Greist et al. 1979;Martinsen et al. 1985;McCann and Holmes 1984;Pappas et al. 1990;Sexton et al. 1989). Research in sports medicine has focused on physiological and immunological consequences of exercise, and little is known about changes in central neurotransmitter function associated with acute or regular endurance training.Several lines of evidence suggest that motor activity affects central serotonin metabolism. In the cerebrospinal fluid of depressed patients, the concentration of the serotonin metabolite 5-HIAA was significantly higher after 4 hours of motor activity than in the same patients after bed rest (Post et al. 1973). Aerobic exercise causes a rise of free fatty acids Fischer et al. From the Department of Psychiatry, University of Göttingen, Göt-tingen, Germany (AB, DM, BB, GH, UB, ER), the Department of Neurology (AG), University of Würzburg, Würzburg, Germany; the Department of Clinical Pharmacology (CHG), Department of Sports Medicine (UH-V), University of Göttingen, Göttingen, Germany; Institute of Sports and Preventive Medicine (TM), University of Saarbrücken, Saarbrücken, Germany.Address correspondence to: Dr. A. Broocks, The Department of Psychiatry, University of Göttingen, von-Siebold-Strasse 5, D-37075 Göttingen, Germany.Received 28 October 1997; revised 12 March 1998; accepted 13 April 1998. N EUROPSYCHOPHARMACOLOGY 1999 -VOL . 20 , NO . 2 Decreased Serotonergic Responsiveness in Marathon Runners 151 1991), which displace free tryptophan (TRP) from its plasma-protein-binding sites (Blomstrand et al. 1988;Chaouloff et al. 1986). This leads to an increase of free TRP in relation to other large neutral amino acids (LNAA) (Chaouloff et al. 1989). Because the TRP influx into the brain correlates with the TRP/LNAA plasma ratio (Fernstrom and Wurtman 1971;Wurtman and Fernstrom 1976), exercise leads to a higher precursor availability in the brain, which, in turn, stimulates 5-HT synthesis (Broocks et al. 1989;Chaouloff 1997). Data from animal studies show th...

show abstract

Psychomotor Activity and Cerebrospinal Fluid Amine Metabolites in Affective Illness

Cited by 263 publications

References 18 publications

The Benefits of Exercise for the Clinically Depressed

The Benefits of Exercise for the Clinically Depressed

Lower CSF Homovanillic Acid Levels in Depressed Patients with a History of Alcoholism

Decreased Neuroendocrine Responses to Meta-Chlorophenylpiperazine (m-CPP) but Normal Responses to Ipsapirone in Marathon Runners

Contact Info

Product

Resources

About