Psychometric properties of self-reported measures of health-related quality of life in people living with HIV: a systematic review

Wen, Huan; Yang, Zhaoxia; Zhu, Zheng; Han, Shuyu; Zhang, Lin; Hu, Yan

doi:10.1186/s12955-021-01910-w

Cited by 11 publications

(5 citation statements)

References 79 publications

(275 reference statements)

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“…PWH in this group not only reported low levels of symptom severity and perceived discrimination but also reported high levels of ADL, medication adherence, quality of life, and self-management capacity. Our results were consistent with previous studies showing that although PWH may have multiple symptoms at same time, the symptom conditions of the majority of PWH may not influence their daily life 34 , 35 . We found that this proportion in our study was approximately 70% in China.…”

Section: Discussionsupporting

confidence: 93%

Identifying subtypes of HIV/AIDS-related symptoms in China using latent profile analysis and symptom networks

Yang

Zhu

Wen

et al. 2022

Sci Rep

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The identification of subgroups of people living with HIV in China based on the severity of symptom clusters and individual symptoms is crucial to determine group-specific symptom management strategies. Participants reported 27 highly prevalent HIV/AIDS-related symptoms. Latent profile analysis based on symptom severity was used to identify person-centered subtypes of HIV/AIDS-related symptoms. Symptom networks were compared among subgroups identified by latent profile analysis. A total of 2927 eligible people living with HIV (PWH) were included in the analysis. Five profiles were identified: “Profile 1: all low symptom severity” (n2 = 2094, 71.54%), “Profile 2: medium symptom severity with syndemic conditions” (n3 = 109, 3.72%), “Profile 3: medium symptom severity with low functional status” (n1 = 165, 5.64%), “Profile 4: medium symptom severity in transitional period” (n4 = 448, 15.31%), and “Profile 5: all high symptom severity” (n5 = 111, 3.79%). Except for Profile 1 and Profile 5, the symptom severity was similar among the other three profiles. Profiles 1 (2.09 ± 0.52) and 4 (2.44 ± 0.66) had the smallest ∑s values, and Profiles 2 (4.38 ± 1.40) and 5 (4.39 ± 1.22) had the largest ∑s values. Our study demonstrates the need for health care professionals to provide PWH with group-specific symptom management interventions based on five profiles to improve their physical and psychological well-being. Future studies should be conducted in different contexts using different symptom checklists to further validate our results.

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Section: Discussionsupporting

confidence: 93%

Identifying subtypes of HIV/AIDS-related symptoms in China using latent profile analysis and symptom networks

Yang

Zhu

Wen

et al. 2022

Sci Rep

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“…Although we excluded many qualitative studies during the title and abstract screening stage, none of these studies researched on content validity. However, this is the same as the other relevant reviews [16,19] that also searched for insufficient studies reporting on the content validity of HIV-related PROMs.…”

Section: Limitationsmentioning

confidence: 95%

“…Furthermore, HIV-specific PROMs are more closely associated with HIV than are generic PROMs. In addition, they have the sensitivity for detecting and quantifying minor changes and specificity needed for HIV-specific domains, such as HIV-related stigma, comorbidities, and ART-related treatment [19]. Some related reviews have recommended a strategy to combine generic and HIV-specific PROMs to supplement HIV-specific health care outcomes that cannot be obtained with generic PROMs alone [20,21].…”

Section: Why Did This Systematic Review Only Include Hiv-specific Pro...mentioning

confidence: 99%

“…After a preliminary literature search in MEDLINE using a comprehensive search strategy (Table S1 in Multimedia Appendix 1), we found some relevant reviews. Wen et al [19] recently conducted a systematic review on a similar topic; however, they only aimed at identifying and assessing the psychometric properties of HRQoL in people living with HIV and AIDS. Engler et al [22] identified 117 different HIV-specific PROMs in 2016; however, they did not quantitatively assess the psychometric properties of these PROMs.…”

Section: Previous Studiesmentioning

confidence: 99%

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HIV-Specific Reported Outcome Measures: Systematic Review of Psychometric Properties

Wang¹,

Zhu²,

Duan³

et al. 2022

JMIR Public Health Surveill

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Background The management of people living with HIV and AIDS is multidimensional and complex. Using patient-reported outcome measures (PROMs) has been increasingly recognized to be the key factor for providing patient-centered health care to meet the lifelong needs of people living with HIV and AIDS from diagnosis to death. However, there is currently no consensus on a PROM recommended for health care providers and researchers to assess health outcomes in people living with HIV and AIDS. Objective The purpose of this systematic review was to summarize and categorize the available validated HIV-specific PROMs in adults living with HIV and AIDS and to assess these PROMs using the Consensus-Based Standards for the Selection of Health Measurement Instruments (COSMIN) methodology. Methods This systematic review followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A literature search of 3 recommended databases (PubMed, Embase, and PsychINFO) was conducted on January 15, 2021. Studies were included if they assessed any psychometric property of HIV-specific PROMs in adults living with HIV and AIDS and met the eligibility criteria. The PROMs were assessed for 9 psychometric properties, evaluated in each included study following the COSMIN methodology by assessing the following: the methodological quality assessed using the COSMIN risk of bias checklist; overall rating of results; level of evidence assessed using the modified Grading of Recommendations, Assessment, Development, and Evaluation approach; and level of recommendation. Results A total of 88 PROMs classified into 8 categories, assessing the psychometric properties of PROMs for adults living with HIV and AIDS, were identified in 152 studies including 79,213 people living with HIV and AIDS. The psychometric properties of most included PROMs were rated with insufficient evidence. The PROMs that received class A recommendation were the Poz Quality of Life, HIV Symptom Index or Symptoms Distress Module of the Adult AIDS Clinical Trial Group, and People Living with HIV Resilience Scale. In addition, because of a lack of evidence, recommendations regarding use could not be made for most of the remaining assessed PROMs (received class B recommendation). Conclusions This systematic review recommends 3 PROMs to assess health outcomes in adults living with HIV and AIDS. However, all these PROMs have some shortcomings. In addition, most of the included PROMs do not have sufficient evidence for assessing their psychometric properties and require a more comprehensive validation of the psychometric properties in the future to provide more scientific evidence. Thus, our findings may provide a reference for the selection of high-quality HIV-specific PROMs by health care providers and researchers for clinical practice and research.

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“…At the time of enrollment (same day of the diagnostic testing for NAFLD), participants also completed the 36-item Short Form (SF-36) Health Survey version 1.0. SF-36 is a widely used and validated tool to evaluate the impact of disease on several physical and mental domains of health in the setting of a variety of chronic diseases, including liver diseases, primary NAFLD and HIV [29][30][31][32][33]. SF-36 measures HRQOL in 8 dimensions: physical functioning, role limitations due to physical health, emotional well-being, role limitations due to emotional problems, energy/fatigue, social functioning, pain, and general health.…”

Section: Study Questionnairesmentioning

confidence: 99%

Non-alcoholic fatty liver disease is not associated with impairment in health-related quality of life in virally suppressed persons with human immune deficiency virus

Gawrieh

Corey²,

Lake³

et al. 2023

PLoS ONE

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Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in persons with HIV (PWH) (HIV-NAFLD). It is unknown if HIV-NAFLD is associated with impairment in health-related quality of life (HRQOL). We examined HRQOL in PWH with and without NAFLD, compared HRQOL in HIV- versus primary NAFLD, and determined factors associated with HRQOL in these groups. Prospectively enrolled 200 PWH and 474 participants with primary NAFLD completed the Rand SF-36 assessment which measures 8 domains of HRQOL. Individual domain scores were used to create composite physical and mental component summary scores. Univariate and multivariate analyses determined variables associated with HRQOL in PWH and in HIV- and primary NAFLD. In PWH, 48% had HIV-NAFLD, 10.2% had clinically significant fibrosis, 99.5% were on antiretroviral therapy, and 96.5% had HIV RNA <200 copies/ml. There was no difference in HRQOL in PWH with or without NAFLD. Diabetes, non-Hispanic ethnicity, and nadir CD4 counts were independently associated with impaired HRQOL in PWH. In HIV-NAFLD, HRQOL did not differ between participants with or without clinically significant fibrosis. Participants with HIV-NAFLD compared to those with primary NAFLD were less frequently cisgender females, White, more frequently Hispanic, had lower BMI and lower frequency of obesity and diabetes. HRQOL of individuals with HIV-NAFLD was not significantly different from those with primary NAFLD. In conclusion, in virally suppressed PWH, HRQOL is not different between participants with or without HIV-NAFLD. HRQOL is not different between HIV-NAFLD and primary NAFLD.

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Psychometric properties of self-reported measures of health-related quality of life in people living with HIV: a systematic review

Cited by 11 publications

References 79 publications

Identifying subtypes of HIV/AIDS-related symptoms in China using latent profile analysis and symptom networks

Identifying subtypes of HIV/AIDS-related symptoms in China using latent profile analysis and symptom networks

HIV-Specific Reported Outcome Measures: Systematic Review of Psychometric Properties

Non-alcoholic fatty liver disease is not associated with impairment in health-related quality of life in virally suppressed persons with human immune deficiency virus

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