Psychometric properties and factor structure of the Neuropsychiatric Inventory Nursing Home version in an elderly neuropsychiatric population

Lange, Rael T.; Hopp, Grace A.; Kang, Nirmal

doi:10.1002/gps.1108

Cited by 82 publications

(98 citation statements)

References 37 publications

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“…This is in line with what is recognized in daily practice and postulated by several authors and previous studies [13,16,29,30] . Nevertheless, most previous studies using the NPI have not been able to distinguish the 2 syndromes of depression and apathy [7,[17][18][19] . The question of whether depression and apathy are distinct syndromes has been the topic of considerable discussion and remains controversial.…”

Section: Discussionmentioning

confidence: 97%

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Neuropsychiatric Syndromes in Dementia

Aalten

Verhey

Boziki³

et al. 2007

Dement Geriatr Cogn Disord

318

133

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Section: Discussionmentioning

confidence: 97%

“…The question of whether depression and apathy belong to the same syndrome or are specific neuropsychiatric symptoms in their own right has been a matter of continuous debate. Some studies found depression and apathy to be integrated into the same subsyndrome [1,7,[17][18][19] , whereas others did not [13,16] .…”

Section: Introductionmentioning

confidence: 99%

Neuropsychiatric Syndromes in Dementia

Aalten

Verhey

Boziki³

et al. 2007

Dement Geriatr Cogn Disord

318

133

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“…Neuropsychiatric symptoms (NPS) are common in patients with dementia [1,2] and include apathy, irritability, agitation, depression, delusions, hallucinations, anxiety, disinhibition, aberrant motor behavior, sleep disturbances, and eating abnormalities [3]. NPS contribute to patient distress, caregiver burden [4,5,6], and institutionalization [7].…”

Section: Introductionmentioning

confidence: 99%

Neuropsychiatric Symptoms in Alzheimer Disease, Vascular Dementia, and Mixed Dementia

et al. 2017

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Background/Aims: Neuropsychiatric symptoms (NPS) are common in Alzheimer disease (AD) and vascular dementia (VaD), and are distressful to patients and caregivers. NPS are likely related to the underlying pathology. Previous studies suggest that frontal lobe lesions and vascular changes such as white matter hyperintensities (WMH) have a significant association with specific NPS. The current study aimed to compare NPS in patients with AD, VaD, and mixed AD/VaD, and to evaluate the differences in the prevalence of NPS in relation to frontal WMH volume. Methods: In total, 180 patients with NPS and MRI data (92 probable AD, 51%; 34 probable VaD, 19%; and 54 probable mixed AD/VaD, 30%) were included in the study. Regression analyses were performed to determine the relationships between NPS prevalence and diagnosis, and between NPS and frontal WMH. Results: VaD patients had significantly more agitation (p < 0.05; 40 vs. 14%) and sleep disturbances (p < 0.05; 57 vs. 32%) than AD patients, and significantly more depression (p < 0.05; 48 vs. 20%) and aberrant motor behaviors (p < 0.05; 31 vs. 13%) than mixed AD/VaD patients. AD patients with delusions had significantly greater right frontal WMH volumes than those without (p < 0.05; delusions 1/0 = 314.8/112.6 mm³). Conclusion: Differences in NPS prevalence are likely related to the underlying pathology and warrant further study as they have implications for treatment.

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“…It demonstrates the feasibility and suitability of utilising a Delphi consensus panel of experts to classify the appropriateness of medications for use in patients with advanced dementia. Data collection indicated that it is feasible to collect information on quality of life, functional performance, [34,35]. This scale assesses frequency and severity of 12 neuropsychiatric symptoms: delusions, hallucinations, agitation, depression, anxiety, euphoria, apathy, disinhibition, irritability, aberrant motor behaviour, nighttime disturbances and appetite/eating change.…”

Section: Resultsmentioning

confidence: 99%

Development and Application of Medication Appropriateness Indicators for Persons with Advanced Dementia: A Feasibility Study

et al. 2014

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USA) for their advice regarding study design. The authors would also like to thank the physicians who participated in the Delphi consensus panel survey, and the residents, their relatives and care home staff who participated in the feasibility study. AbstractBackground: No studies have been conducted in the United Kingdom (UK) context to date which categorise medications in terms of appropriateness for patients with advanced dementia, or which examine medication use in these vulnerable patients.Objectives: To categorise the appropriateness of a comprehensive list of medications and medication classes for use in patients with advanced dementia; to examine the feasibility of conducting a longitudinal prospective cohort study to collect clinical and medication use data;and to determine the appropriateness of prescribing for nursing home residents with advanced dementia in Northern Ireland (NI), using the categories developed.Methods: Three-round Delphi consensus panel survey of expert clinicians, to categorise the appropriateness of medications for patients with advanced dementia (defined as having Functional Assessment Staging [FAST] scores ranging from 6E to 7F). This was followed by a longitudinal prospective cohort feasibility study which was conducted in three nursing homes in NI. Clinical and medication use for participating residents with advanced dementia (FAST scores ranging from 6E to 7F) were collected and a short test of dementia severity administered.These data were collected at baseline and every three months for up to nine months or until death. For those residents who died during the study period, data were also collected within 14 days of death. The appropriateness ratings from the consensus panel survey were retrospectively applied to residents' medication data at each data collection timepoint to determine the appropriateness of medications prescribed for these residents.Results: Consensus was achieved for 87 (90%) of the 97 medications and medication classes included in the survey. Fifteen residents were recruited to participate in the longitudinal prospective cohort feasibility study, four of whom died during the data collection period. Mean numbers of medications prescribed per resident were 16.2 at baseline, 19.6 at three months, 17.4 at six months and 16.1 at nine months respectively. Fourteen residents at baseline were taking at least one medication considered by the consensus panel to be never appropriate, and approximately 25% of medications prescribed were considered to be never appropriate. Postdeath data collection indicated a decrease in the proportion of never appropriate medications and an increase in the proportion of always appropriate medications for those residents who died. Conclusions

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Psychometric properties and factor structure of the Neuropsychiatric Inventory Nursing Home version in an elderly neuropsychiatric population

Cited by 82 publications

References 37 publications

Neuropsychiatric Syndromes in Dementia

Neuropsychiatric Syndromes in Dementia

Neuropsychiatric Symptoms in Alzheimer Disease, Vascular Dementia, and Mixed Dementia

Development and Application of Medication Appropriateness Indicators for Persons with Advanced Dementia: A Feasibility Study

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