Psychometric Evaluation of PROMIS Sexual Function and Satisfaction Measures in a Longitudinal Population-Based Cohort of Men With Localized Prostate Cancer

Abstract

Background There are multiple treatment options for men with localized prostate cancer that provide similar curative efficacy but differ in their impact on sexual functioning. Aim This study evaluated the psychometric properties of the Patient-Reported Outcomes Measurement Information System® (PROMIS® ) Sexual Function and Satisfaction (SexFS) measures, including items from version 1 and 2 of the short forms. Methods A population-based cohort of men across North Carolina completed surveys via phone interviews at baseline (prior to treatment) and at 3-, 12-, and 24-months post cancer treatment initiation. Surveys included the PROMIS SexFS domains of Interest in Sexual Activity, Erectile Function, Orgasm, and Satisfaction and the Prostate Cancer Symptom Indices (PCSI). Analyses included descriptive statistics, assessment of factorial validity using confirmatory factor analysis (CFA) and item response theory (IRT), tests for differential item functioning, assessment of convergent validity using correlations, and evaluation of responsiveness of the PROMIS SexFS measures over time. We hypothesized that men undergoing surgery (prostatectomy) would report the poorest sexual function at 3-month survey. Results Sample size varied by assessment point and ranged from 332 to 939 men, consisting of 30% non-white men and 30% of sample with a high school degree or less. The items within the PROMIS orgasm domain did not associate together to form a unidimensional scale. PROMIS measures of Interest in Sexual Activity, Erectile Function, and Satisfaction were unidimensional and highly correlated with related PCSI measures (e.g., erectile function, r=0.84–0.95). Erectile Function in the Surgery group declined more at 3-months compared to the No-Surgery group (2 points); this difference narrowed at 12- and 24-months as the Surgery group recovered over time. Results were similar for PROMIS Interest in Sexual Activity and PROMIS Satisfaction scales. Clinical Implications The PROMIS SexFS measures may be used to identify effective interventions to treat sexual dysfunction and monitor sexual functioning in men with prostate cancer over time. Strengths & Limitations This study was limited to men living in North Carolina who could self-report their HRQOL in English. However, this study was able to include more men from vulnerable populations by allowing the men to self-report over the phone. Conclusion This study provided strong support for use of the PROMIS SexFS (version 2) measures in men with localized prostate cancer to assess sexual interest, erectile function and satisfaction over time.

Sickle Cell Transplantation Evaluation of Long-term and Late Effects Registry (STELLAR) to Compare Long-term Outcomes After Hematopoietic Cell Transplantation to Those in Siblings Without Sickle Cell Disease and in Nontransplanted Individuals With Sickle Cell Disease: Design and Feasibility Study

“…For post-HCT patients and nontransplanted controls with SCD who were ≥18 years old, we administered offspring and pregnancy history surveys, reproductive health from the BMTSS, and PROMIS sexual function and satisfaction surveys v2.0 [ 7 , 8 ]. Blood samples were collected for assay of reproductive hormones, including anti-Mullerian hormone (AMH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and estradiol in females and LH, FSH, and testosterone in males.…”

Feasibility of a Multi-Component Strengths-Building Intervention for Caregivers of Persons With Heart Failure

“…Effect sizes were classified as small (.20), medium (.50), and large (.80). Although we did not power for this early pilot, we used Wilcoxon signed rank Zarit burden interview (short version) 12 .86 (Bédard et al, 2001) Summed scores range from 0 to 48 with higher scores indicating higher burden Fatigue PROMIS-fatigue short form 8 .9 (Kamudoni et al, 2022;Reeve et al, 2016) Scores range from 0 to 35 with higher scores indicating higher levels of fatigue (T-scores used for analysis) Social support ENRICHD social support 8 .89 (Vaglio et al, 2004) Scores range from 8 to 34 with higher score indicating higher level of social support Self-efficacy…”

Patient-Reported Outcomes in Surgical Oncology: An Overview of Instruments and Scores

“…These assessments can be given pre-and postoperatively, and used to better inform patients about surgical decision making and their expected functional recovery. Surgical oncology studies using PROMIS Network tools have recently been published in colorectal [25], lung [26], metastatic bone [27], prostate [28], and gynecologic cancers [29].…”